Cordaflex RD tabs 40mg #30

Instruction for Cordaflex

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Composition

The coated tablets contain 10 mg of nifedipine in each as an active substance. To auxiliary substances: polyvinyl butyral in an amount of 0.7 mg; talc (1 mg); 0.3 mg magnesium stearate; 4 mg hydroxypropylcellulose; lactose monohydrate (15 mg); croscarmellose sodium (13 mg); microcellulose (46 mg). The membrane consists of hypromellose - 2.63 mg; titanium dioxide C.I. 77891 0.82 mg; yellow iron oxide 0.3 mg and magnesium stearate 0.25 mg.
Tablets with prolonged action, with a film coat contain the same active substance, but in a dose of 20 mg. As auxiliary in each of them are such substances: microcellulose (99 mg); lactose monohydrate (30 mg); croscarmellose sodium (26 mg); copolymers of methyl methacrylate and ethyl methacrylate in a ratio of 1: 2 (1.9 mg); talc (2 mg); magnesium stearate (0.6 mg); giprolase (0.5 mg). The film membrane is made of hypromellose - 5.26 mg; titanium dioxide - 1.64 mg; red iron oxide - 0.6 mg; magnesium stearate - 0.5 mg.

Form of issue

There are two versions of the form of release of the medicine:
    Tablets in a shell, weighing 10 mg. Each 100 tablets are placed in a bottle of brown glass. Vials are packed individually in cardboard packs.
    Film-coated tablets with prolonged action. Each tablet weighs 20 mg. Put on 30 or 60 tablets in bottles of brown glass. Vials should be sealed with polyethylene caps, which have control of the first autopsy. The bottle is packed in a cardboard box.

pharmachologic effect

Hypotensive (lowers blood pressure) and antianginal effect.

Pharmacodynamics and pharmacokinetics

Nifedipine is a selective blocker of slow calcium channels, is among 1,4-dihydropyridine derivatives. Its effect is manifested in a decrease in the current of extracellular calcium ions in cardiomyocytes and smooth muscle cells of the arteries. Nifedipine can also increase renal blood flow, causing a mild natriuresis.
After taking one Cordaflex pill that has a prolonged effect, the clinical effect usually develops in 20 minutes, the effect lasts from 12 to 24 hours.
After taking it quickly, almost completely (at least 90%) is absorbed from the digestive tract. A bioavailability of the drug is in the range of 40-70%.
The maximum concentration of the active substance in the blood is 30-60 minutes after taking the drug.
After taking one tablet with prolonged action, the therapeutic concentration in the blood plasma is reached in an hour and remains at an equal level up to 6 hours, in the next 30-36 hours a gradual decrease in the concentration is observed.
Nifedipine has the property of binding to blood plasma proteins, in particular albumins, to penetrate the blood-brain barrier (in a small amount - not more than 5%), through the placenta, it can be excreted in breast milk.
The half-life is 2 hours for a 10 mg tablet, for a tablet that has a sustained action of 20 mg - about 3.8-16.9 hours.

Indications for use

Indications for the use of Cordaflex are associated with cardiovascular diseases. Arterial hypertension of varying severity, including hypertensive crises - is the main, from which Cordaflex tablets help.
Also, these pills are prescribed for patients suffering from coronary heart disease, including cases of vasospastic and stable angina.

Contraindications

Contraindications are:
    intolerance to nifedipine, other derivatives of 1,4-dihydropyridine, additional components that make up tablets;
    arterial hypotension;
    unstable angina;
    presence at the moment or most recently acute myocardial infarction, expressed aortic stenosis;
    idiopathic subaortic stenosis;
    chronic heart failure during decompensation;
    childhood.
With special care is assigned to elderly patients, those with impaired renal function, patients with diabetes mellitus.

Side effects

Cordaflex is usually positively tolerated. Side effects appear rarely, often at the beginning of treatment (then they can become weaker or disappear).
There are such variants of side effect:
    On the heart and blood vessels: lowering of blood pressure, hyperemia of the face and trunk, edema on the limbs, acceleration of the heart rhythm, paradoxical attack of angina, development of acute heart failure.
    On the nervous system: increased fatigue, dizziness, weakness, emotional lability, sleep disorders, headache, tremor, paresthesia.
    On the gastrointestinal tract: the occurrence of heartburn, nausea, vomiting, flatulence, stools, dryness or inflammation of the oral mucosa, intrahepatic cholestasis, and an increase in the activity of certain hepatic enzymes.
    On the circulatory system: thrombocytopenia, leukopenia, anemia.
    On the urinary system: increased daily diuresis, nighttime urination, decreased kidney function.
Allergic reactions may occur in the form of urticaria, exanthema, skin itching.

Instructions for use Cordaflex (Method and dosage)

The drug is taken orally. Coated tablets of 10 mg are swallowed whole before meals, washed down with water.
Dosage is established individually, because it depends very much on the severity of the disease, the type of disease and the body's response to the therapy. Begin with 1 tablet (10 mg) 3 times a day. Between the drug should take at least 2 hours. The maximum daily dose is 40 mg.
Tablets that have a prolonged action, with a film coat swallowed whole, washed down with water. In this case, the initial dose is 1 tablet 2 times a day. The daily dose in any case is divided into 2 doses, between which a 12-hour interval should be observed.
According to the instructions for the use of Cordaflex, the drug should be withdrawn gradually.

Overdose

In case of an overdose of nifedipine, the following consequences may occur:
    arterial hypotension;
    pain behind the sternum (like an attack of angina pectoris);
    tachycardia;
    loss of consciousness;
    collapse;
    ventricular or nodal extrasystole;
    bradycardia.
In severe cases, it is possible to develop metabolic alkalosis, cardiogenic shock with pulmonary edema, hypoxia, hyperkalemia, as well as disorders of consciousness that can go into coma.

Interaction

Cordaflex can not be prescribed with alcohol-containing drugs.
It is possible to develop orthostatic hypotension when used with methyldopa, clonidine, and also with prazosin and octadine.
Cimetidine, ranitidine and tricyclic antidepressants will potentiate an antihypertensive effect.
When a combination of Cordaflex and theophylline and digoxin should be monitored plasma concentrations of these drugs, as it may increase.
Phenytoin, calcium and rifampicin drugs reduce the effect of nifedipine.
Cordaflex reduces the rate of vincristine elimination, which increases the risk of side effects. Therefore, dose adjustment is necessary.
Erythromycin, diltiazem, grapefruit juice in large quantities, azole antimicrobials when taken with nifedipine significantly slows its metabolism.

Terms of sale

To buy online Cordaflex you don't need a prescription.

Storage conditions

The temperature of the room in which the medicine is stored should not exceed 30 ° C.
Shelf life - 5 years.

Children

Not used in pediatrics.

With alcohol

Do not use concurrently.

In pregnancy and lactation

Can be prescribed during pregnancy only if other drugs are ineffective.
During lactation, medications containing nifedipine should not be given.

Reviews of Cordaflex

Reviews are various, as the drug is widely used. If you pay attention to the doctors' opinions about the result of using Cordaflex, they note its relatively short-term effect on the body, as a result of which it should be applied at least 2 times a day. Plus the drug is that it is not addictive.