Cordarone tabs 200mg #30

Instruction for Cordarone

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Composition

1 tablet contains 200 mg of active ingredient amiodarone hydrochloride. Additional components are: povidone, starch, silicon dioxide, lactose monohydrate, magnesium stearate.
1 ml of the solution contains 50 mg of active ingredient amiodarone hydrochloride. Additional components are: polysorbate, injection water, benzyl alcohol.

Form of issue

It is produced in tablet form, in the form of a solution.

pharmachologic effect

Antiarrhythmic agent, inhibitor of repolarization.

Pharmacodynamics and pharmacokinetics

The main substance is amiodarone. Has coronarodulatory, antianginal, hypotensive, alpha-adrenergic blocking, beta-adrenergic blocking effects. The action of the drug reduces the need for cardiac muscle in oxygen, which explains the antianginal effect. Cordarone inhibits the work of alpha, beta-adrenoreceptors of the cardiovascular system, without blocking them.
Amiodarone reduces the sensitivity of the sympathetic nervous system to hyperstimulation, lowers the tone of the coronary arteries, improves blood flow, calms the pulse, increases the energy reserves of the myocardium, and lowers blood pressure.
Antiarrhythmic effect is achieved by the influence on the course of electrophysiological processes in the myocardium, the prolongation of the action potential of myocardiocytes, an increase in the refractory, effective atrial period, the bundle of the Hisnia, the AV node, and the ventricles.
Cordarone is able to inhibit diastolic, slow depolarization of the membrane of the cells of the sinus node, inhibit atrioventricular conduction, cause bradycardia. The structure of the main component of the drug is similar to the thyroid hormone.

Indications for use Cordarone

The drug is prescribed for paroxysmal rhythm disorders (treatment, prevention). Indications for the use of Cordarone are: ventricular fibrillation, fatal ventricular arrhythmias, supraventricular arrhythmias, atrial flutter, atrial paroxysm, angina pectoris, ventricular arrhythmia in patients with Chagas myocarditis, arrhythmias in coronary insufficiency, parasystole.

Contraindications

Cordarone is not prescribed for sinus bradycardia, intolerance to iodine, amiodarone, cardiogenic shock, collapse, hypokalemia, hypothyroidism, arterial hypotension, breastfeeding, interstitial lung diseases, pregnancy, MAO inhibitors, hypokalemia, atrioventricular blockade of 2-3 degrees.
The elderly, with pathology of the liver, heart failure, patients under 18 years old, with pathology of the hepatic system appoint with caution.

Side effects

Nervous system: sleep disorders, memory disorders, peripheral neuropathy, paresthesia, auditory hallucinations, fatigue, depression, dizziness, weakness, headaches, optic neuritis, intracranial hypertension, ataxia, extrapyramidal manifestations.
Sense organs: microcellular retina, deposition of lipofuscin in the corneal epithelium, uveitis.
Cardiovascular system: a drop in blood pressure, tachycardia, progression of CHF, atrioventricular block, sinus bradycardia. Metabolism: thyrotoxicosis, hypothyroidism, increase in T4 level.
Respiratory system: apnea, bronchospasm, pleurisy, pulmonary fibrosis, alveolitis, anterstic pneumonia, dyspnea, cough.
Digestive system: cirrhosis of the liver, jaundice, cholestasis, toxic hepatitis, increase in the level of liver enzymes, loss, blunting of taste perception, decreased appetite, vomiting, nausea.
Prolonged use causes aplastic anemia, hemolytic anemia, thrombocytopenia, allergic reactions, dermatitis. With parenteral administration, phlebitis develops.
Cordarone may cause the following side effects: alopecia, decreased potency, myopathy, vasculitis, epididymitis, photosensitization, skin pigmentation, increased sweating.

Instructions for use Cordarone (Method and dosage)

Cordarone solution, instructions for use

The solution is administered intravenously according to the 5 mg / kg scheme for arresting acute rhythm disturbances, patients with CHF are calculated according to the 2.5 mg / kg scheme. Infusions are carried out for 10-20 minutes.

Cordarone tablets, instructions for use

Tablets are taken before meals: 0.6-0.8 grams for 2-3 meals; dosage is reduced after 5-15 days to 0.3-0.4 grams per day, after which they switch to maintenance therapy 0.2 grams per day for 1-2 doses.
To prevent cumulation, the drug is taken for 5 days, after which it takes a break for 2 days.

Overdose

It is characterized by a drop in blood pressure, an atrioventricular block, a bradycardia.
Required appointment kolestiramina, gastric lavage, installation of a pacemaker. Hemodialysis is recognized as ineffective.

Interaction

Cordarone causes an increase in the level of procainamide, phenytoin, quinidine, digoxin, cyclosporine, flecainide in blood plasma.
The drug causes an increase in the effects of indirect anticoagulants (acenocoumarol and warfarin).
With the appointment of warfarin, its dosage is reduced to 66%, with the appointment of acenocoumarol - by 50%, mandatory control prothrombin time.
"Loop" diuretics, astemizole, tricyclic antidepressants, phenothiazines, terfenadine, thiazides, sotalol, glucocorticosteroids, laxatives, pentamidine, tetracosactide, first-line antiarrhythmics, amphotericin B may cause arrhythmogenic effect.
Cardiac glycosides, verapamil, beta-adrenoblockers increase the likelihood of suppression of atrioventricular conduction, the development of bradycardia.
Medicines that cause photosensitivity may provoke an additive photosensitizing effect.
Arterial hypotension, bradycardia, conduction disorders can develop during oxygen therapy, with general anesthesia with the use of drugs for inhalation anesthesia.
Cordarone is able to suppress the absorption of pertechnet sodium, sodium iodide by the thyroid gland.
With the simultaneous use of lithium drugs, the risk of hypothyroidism increases. Cimetidine increases the half-life of the main component, and colestyramin reduces its absorption in blood plasma.

Terms of sale

The prescription is not required to buy Cordarone online.

Storage conditions

In a place inaccessible to children at a temperature of no more than 25 degrees Celsius.
Shelf life not more than two years.

special instructions

On the eve of the appointment of antiarrhythmic therapy, an examination of the hepatic system is performed, the thyroid gland is evaluated, an X-ray examination of the pulmonary system is performed, and the level of electrolytes in plasma is determined.
During treatment, it is necessary to control the level of liver enzymes, ECG. The function of external respiration is investigated every six months, radiologic examination of the lungs is carried out once a year, the level of thyroid hormones is determined every 6 months. In the absence of a clinical picture of thyroid dysfunction, antiarrhythmic treatment continues.
It is recommended to use special sunscreens, avoid direct sunlight to prevent the development of photosensitization. It is necessary to periodically observe the ophthalmologist for the diagnosis of deposits in the cornea.
Removing the drug can cause a relapse of rhythm disturbances.
Parenteral administration of Cordarone is possible only in hospital conditions under the control of blood pressure, pulse, ECG.
The appointment for breastfeeding and pregnancy is possible only in cases that threaten the life of a woman.
After discontinuation of treatment, the pharmacodynamic effect persists for 10-30 days.
Cordarone in its composition contains iodine, which can provoke false-positive tests for the determination of radioactive iodine in the thyroid gland.
During surgical interventions, the team should be informed about the use of the drug because of the possibility of developing a distress syndrome of acute form.
Amiodarone affects the management of motor vehicles, attention.
INN: Amiodarone.

How long can I take the medicine?

After saturation with the drug (usually within a week), they switch to maintenance therapy, which can last quite a long time. It is necessary to perform therapy under the supervision of the attending physician.

Cordarone and alcohol

The drug is not compatible with alcohol.

Reviews of Cordarone

There is a large number of opinions that the drug is effective in atrial fibrillation, indeed relieves symptoms and facilitates the general condition.
However, there are many reviews about Cordarone on the forums, which indicate that the drug does not help at all or helps poorly.