Ferrovir solution 1.5% 5ml #5

Ferrovir user manual

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Composition

1 ml yellowish solution for intramuscular injection contains 15 mg of deoxyribonucleate Na, 0.048 mg of oxide chloride Fe and water acts as an auxiliary component of the filler.

Form release

Almost transparent solution without specific additional inclusions with a concentration of active substances 15 mg/ml available in bottles of brown glass with a volume of 2 or 5 ml. Each bottle is corked with a stopper rubber, and optionally, the run-in tear-off cap of aluminium with plastic head.
In a special blister tray has 10 vials of 2 ml or 5 vials of 5 ml. In cardboard pack contains the instruction from the manufacturer and 1 blister tray with vials.

Pharmacological action

Activator fungicidal, antiviral, antimicrobial immunity. Against viruses containing DNA and RNA, there is a pronounced antiviral activity.
The active substance of natural origin is characterized by a pronounced immunomodulatory effect.
With HIV/AIDS, 14-day course therapy can raise the level of CD4+ lymphocytes. The effect lasts 30-45 days. Additionally, there is a decrease in viral load in the body, which is manifested by a drop in the level of HIV RNA in dynamics with initial indicators.
A 10-day course of therapy reduces the duration of recurrence of herpesvirus infection and provides long-term remission with a constantly recurring course of the disease.
Complex therapy of patients suffering from chronic hepatitis C contributes to the reduction of HCV replication viral activity (applies to all genotypes), and translates the process into the latent phase, followed by the restoration of hepatocellites and inhibition of hepatitis virus replication.
Ferrovir is active against opportunistic viruses and major diseases.
In the medical literature of the corresponding direction there are data on the positive results of treatment of diseases and conditions caused by the Epstein-Barr virus and human papilloma.

Pharmacodynamics and pharmacokinetics

Absorption and subsequent distribution in tissues and organs after intramuscular injection is fast enough. The distribution is carried out by means of an endolymphatic transport pathway. Ferrovir is characterized by a high tropism to hematopoietic organs.
The drug is embedded in the cell structure, taking part in the metabolism of cells. Daily course application leads to cumulation of active ingredients in tissues and organs.
The maximum concentration of the active component is registered in 0.5 hours, after which there is a gradual decrease, which is explained by the distribution of the drug in the body. T1 / 2 equals 36 hours. Multiple injections (daily for 4 days) contribute to the accumulation of medication in the bone marrow, spleen, lymphatic system.
After the 5th injection is not registered increase of concentration of active substances in tissues and organs. Metabolites are excreted partly with feces, and for the most part with urine. On average, the medicine is kept in the body for 72 hours.

Indications for use

hepatitis C;
herpes virus infection (any localization is allowed), the source of which is the herpes virus types 1 and 2;
generalized herpesvirus infection in immune-competent group of people;
vernal encephalitis;
cervical dysplasia caused by HPV human papillomavirus as part of etiopathogenetic therapy;
papillomavirus infection (dysplasia, warts, warts);
chronic and recurrent genital herpes;
cytomegalovirus infection;
treatment of patients suffering from HIV / AIDS.

Contraindications

breast feeding;
individual hypersensitivity;
pregnancy;
child age (not applicable in Pediatrics).

Side effect

Ferrovir well tolerated by. It is rarely noted in the area of injection slight soreness and hyperemia of the skin; a short-term rise in body temperature to 38 degrees is possible.

Instructions for use of Ferrovir (Method and dosage)

The medicine is not used in pediatric practice and is intended only for intramuscular administration (slowly for 1-2 minutes).
Instructions for use of Ferrovir in herpesvirus infection: twice a day for 10 days to enter intramuscularly 5 ml solution. Recent clinical trials have shown the effectiveness of another treatment regimen: 1 time a day for 75 mg with an interval of 24 hours, the duration of therapy – 10 days.
Cytomegalovirus infection, genital herpes (recurrent, chronic course): twice a day administered 5 ml, course for 10-15 days.
Complex treatment of combined viral genital infection (herpes + papillomavirus): intramuscularly 5 ml 1 time per day, interval – 24 hours, course – 10 days.
Treatment of human papillomavirus infection: 5 ml, an interval of 48 hours, the course is 10 days.
Treatment of cervical dysplasia associated with HPV papilloma virus is carried out according to the scheme: 5 ml, interval – 48 hours, the course includes 10 injections.
Cytomegalovirus infection: twice a day intramuscularly administered 5 ml, course-10 days.
Tick-borne encephalitis: intramuscularly twice a day administered at 15 mg / ml, 5-10 days course.
AIDS, HIV: twice a day for 5 ml, course treatment is designed for 2 weeks. The repeated course can be conducted as necessary through 1-1.5 months.
Hepatitis C: twice a day injects 5 ml for 2 weeks. Further, within 14 days, the drug is administered every other day in the same daily dose.

Overdose

The adverse reactions in overdose have not been identified.

Interaction

Ferrovir is able to potentiate the effects of anticoagulants.
The drug reduces the severity of negative reactions and reduces the toxicity of antifungal, antiviral, antimicrobial agents and cytostatics used in complex therapy.
This effect is explained by the optimization of metabolic processes in liver cells hepatocytes and cytoprotective properties of Ferrovir.

Terms of sale

To buy Ferrovir the prescription is not required.

Storage conditions

Opened vials are used immediately, storage shall not be allowed. Temperature regime-4-20 degrees.
Shelf life - 5 years.

Special instruction

Slow and deep intramuscular injection reduces the severity of pain. Intravenous injections are unacceptable.
Clinical studies of the corresponding profile proved the high efficiency of the drug in the treatment of most viral infections (papillomavirus, cytomegalovirus, HSV). When herpetic infection is effective as a combination and mono-therapy.

Pregnancy and lactation

Breastfeeding and pregnancy are absolute contraindications.

Reviews of Ferrovir

Reviews of Ferrovir on various forums. Someone notes that after the course of therapy, he achieved a long remission of the viral disease, significantly increasing immunity and resistance even to other diseases. And someone said that the viral infection from the body is impossible to deduce, which casts doubt on the effectiveness of the medication.
However, there is an extensive evidence base, confirming the high efficiency of the drug in the treatment of all diseases declared by the manufacturer in the instructions. When HPV positive feedback, both from doctors and from patients, because it is the human papillomavirus can cause cervical cancer, while the drug suppresses the activity of HPV.
Patients note the high cost of the drug, which makes it inaccessible for use in wide circles. There is no evidence base for the safety of the drug in the treatment of viral diseases of children, which limits the use of Ferrovira in pediatric practice, as written by the parents of young patients in the appropriate forums.