Erythromycin tabs 250mg #20

Instruction for Erythromycin

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Composition

One tablet of Erythromycin contains 100, 200, 250 or 500 mg of the active ingredient.
In 1 g of ointment for external use contains 10,000 units of active ingredient. Additional substances: paraffin white, lanolin, sodium metabisulphite.
In 1 g of eye ointment contains 10,000 units of active substance.
In 1 vial of lyophilizate solution of erythromycin I / O contains 100 mg of active substance in the form of erythromycin phosphate.

Form of issue

It is produced in tablet form, in the form of a solution, ointment, ophthalmic ointment Erythromycin.

pharmachologic effect

Bacteriostatic antibiotic with antibacterial effect.

Pharmacodynamics and pharmacokinetics

The principle of action is based on binding to the ribosomal subunit, which leads to the destruction of peptide bonds between amino acid molecules, the process of protein synthesis in the microorganism is blocked. It acts on gram-positive cocci, gram-negative flora. Erythromycin is a motilin receptor agonist. The drug increases the rate of evacuation in the digestive tract due to the effect on the amplitude of contraction of the pylorus, has a positive effect on antrum-duodenal coordination.

Indications for use Erythromycin

From what tablets and for what ointment?

Indications for the use of the drug are infections of bacterial etiology: trachoma, pertussis, erythrasma, diphtheria, listeriosis, legionnaires, brucellosis, scarlet fever, gonorrhea, amoebic dysentery, pneumonia in children, primary syphilis, uncomplicated chlamydia, sinusitis, cholecystitis, tonsillitis, otitis, tracheitis , youthful acne, bronchitis. The medicine is prescribed for the prevention of streptococcal infection in patients with rheumatism. When allergic to penicillin is an antibiotic reserve.

Contraindications

Erythromycin is not used with a significant decrease in hearing, with intolerance of the components, during pregnancy, with the administration of astemizole, terenacin. When arrhythmia, breastfeeding, jaundice, kidney pathology is prescribed with caution.

Side effects

Hearing organs: ototoxicity.
Digestive system: tenesmus, epigastric pain, dysbacteriosis, vomiting, cholestatic jaundice, candidiasis of the mouth, pancreatitis.
Cardiovascular system: atrial flutter, atrial fibrillation. It is possible to develop phlebitis at the injection site, allergies, eosinophilia

Instructions for use Erythromycin (Method and dosage)

The drug is taken an hour before meals, squeezed with enough liquid.

Erythromycin tablets, instructions for use

The average dosage for adults is 200-400 milligrams every 6 hours. If necessary, the daily dose can be increased to 4 grams.
Children: 40 mg / kg per day, for 2-4 admission. The duration of antibiotic therapy is 7-10 days.

Overdose

When an overdose is recorded, acute renal failure, hearing impairment. It is recommended timely washing of the stomach, the use of enterosorbents. Forced diuresis, peritoneal dialysis and hemodialysis do not bring an effect.

Interaction

Erythromycin has a negative effect on the bactericidal effect of carbopenem, cephalosporins, penicillin and other beta-lactam antibiotics. With intravenous administration, the effect of ethanol is increased, and the nephrotoxicity of cyclosporine is increased. Antibiotic reduces the clearance of midazolam, triazolam, slows down the elimination of coumarin anticoagulants, felodipine, methylprednisolone. Rhabdomyolysis increases with simultaneous intake of Lovastatin. Erythromycin enhances the bioavailability of digoxin. Negatively affects the effectiveness of hormonal contraception. Arrhythmia develops with simultaneous admission of astemizole and terendadine. The drug is incompatible with chloramphenicol, clindamycin.

Terms of sale

The recipe is not required.

Storage conditions

In a place protected from moisture, inaccessible to children at a temperature of no more than 25 degrees Celsius.

Shelf life

Not more than 3 years

special instructions

In severe bacterial infection, Erythromycin is administered intravenously in the form of erythromycin phosphate. At the time of taking the medication, breastfeeding is stopped. With prolonged antibacterial therapy, regular monitoring of the liver is performed. Ototoxicity is more common in people with renal system pathology. Tablets can not be washed down with milk products or milk.

Erythromycin in pregnancy

In animal studies, it was found that the substance penetrates the placenta, is found in low concentrations in the blood plasma, but does not have a negative effect on the fetus.
Studies in pregnant women were not performed.
Proceeding from this, it is worth noting that during pregnancy the drug can be used only if the possible benefit from its use is higher than the possible risk to the fetus.
It is not recommended to use the medication and breastfeeding. If possible, stop breastfeeding

Erythromycin Analogs

Analogues are Erythromycin ointment.

Reviews about Erythromycin

Effective drug for the control of pustular formations. Has antibacterial and anti-acne action. A large and frequent manifestation of side effects was noted. Those who use the drug sometimes remark that harm from the medicine is more than good.

Erythromycin in angina

Antibiotic is effective in case of angina. Drunk for 5 to 14 days. Required appointment from a doctor.