Tetracyclin-lekt tabs 100mg #20

Tetracyclin tablets instruction for use

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pharmachologic effect

Antibiotic of a wide spectrum of action. Has a bacteriostatic effect due to suppression of protein synthesis of pathogens.
It is active against aerobic gram-positive bacteria: Staphylococcus spp. (including strains producing penicillinase), Streptococcus spp .; Gram-negative bacteria: Neisseria gonorrhoeae, Bordetella pertussis, Enterobacter spp., Escherichia coli, Klebsiella spp., Salmonella spp., Shigella spp .; anaerobic bacteria: Clostridium spp.
It is also active against Rickettsia spp., Chlamydia spp., Mycoplasma spp., Spirochaetaceae.
Pseudomonas aeruginosa, Proteus spp., Serratia spp., Most strains of Bacteroides fragilis, most fungi, small viruses are resistant to tetracycline.

Pharmacokinetics

After ingestion, 60-80% of the dose is absorbed from the digestive tract. Quickly distributed in most tissues and body fluids. Penetrates through the placental barrier, excreted in breast milk. It is excreted in urine and feces unchanged.

Indications

Infectious-inflammatory diseases caused by microorganisms sensitive to tetracycline, incl. pneumonia, bronchitis, pleural empyema, tonsillitis, cholecystitis, pyelonephritis, intestinal infections, endocarditis, endometritis, prostatitis, syphilis, gonorrhea, brucellosis, rickettsiosis, purulent infections of soft tissues, osteomyelitis; trachoma, conjunctivitis, blepharitis; acne.
Prevention of postoperative infections.

Contraindications

Hepatic insufficiency, leukopenia, mycoses, children under 8, pregnancy, lactation (breastfeeding), hypersensitivity to tetracycline.

Dosage

Inside adults - 250-500 mg every 6 hours. Children older than 8 years - 25-50 mg / kg every 6 hours.
External apply several times a day, if necessary, impose a weak bandage.
Locally - 3-5 times / day.
The maximum daily intake for adults with oral intake is 4 g.

Side effects

From the digestive system: nausea, vomiting, anorexia, abdominal pain, diarrhea, constipation, dry mouth, glossitis, discoloration of the tongue, esophagitis, transient increase in hepatic transaminase activity, alkaline phosphatase, bilirubin concentration, residual nitrogen.
From the side of the central nervous system: dizziness, headache.
On the part of the hematopoiesis system: neutropenia, thrombocytopenia, hemolytic anemia.
Allergic reactions: skin rash, itching, eosinophilia, Quincke's edema.
Dermatological reactions: photosensitization.
Effects caused by chemotherapeutic action: candidiasis stomatitis, vulvovaginal candidiasis, intestinal dysbiosis.
Local reactions: soreness in the injection site.
Other: hypovitaminosis of B vitamins.

Drug Interactions

Preparations containing metal ions (antacids, preparations containing iron, magnesium, calcium) form inactive chelates with tetracycline, therefore it is necessary to avoid their simultaneous appointment.
It is necessary to avoid the combination with penicillins, cephalosporins, which have bactericidal action and are antagonists of bacteriostatic antibiotics (including tetracycline).
With the simultaneous use of tetracycline with retinol may develop intracranial hypertension.
When used simultaneously with colestyramine or colestipol, there is a violation of absorption of tetracycline.

special instructions

With prolonged use, it is necessary to periodically monitor the functions of the kidneys, liver, and hematopoiesis.
The use of tetracycline in children during the development of teeth can lead to an irreversible change in their color.
During the treatment for the prevention of hypovitaminosis should be used vitamins B, K, brewer's yeast.
Tetracycline should not be taken concomitantly with milk and other dairy products. at the same time, absorption of the antibiotic is impaired.

Pregnancy and lactemia

Tetracycline is contraindicated in pregnancy and lactation.
Penetrates through the placental barrier. May cause long-term discoloration of the teeth, hypoplasia of the enamel, suppression of the growth of the bones of the fetal skeleton. In addition, tetracycline may be the cause of the development of fatty liver infiltration.

Application in childhood

Contraindicated in childhood to 8 years. The use of tetracycline in children during the development of teeth can lead to an irreversible change in their color.

With violations of liver function

Contraindicated in liver failure.