Metformin 500mg #60

Instruction for Metformin

You can buy Metformin here

Composition

The tablets contain the active substance - metformin hydrochloride for 500, 850, 1000 mg.
Additional ingredients: povidone and magnesium stearate.
The film membrane consists of hypromellose, and in 1000 mg tablets also from the Opadry clia, macrogol 400 and 8000.

Form of issue

The drug is available in tablets coated with a white film membrane. In this case, tablets of 500 and 850 mg have a round shape, and 1000 mg is oval. The preparation is offered for 20 pcs. in a cell, 3 cells in a stack.

pharmachologic effect

Tablets have a hypoglycemic effect.

Pharmacodynamics and pharmacokinetics

This drug can reduce hyperglycemia, without causing the development of hypoglycemia. At the same time, insulin secretion is not stimulated, hypoglycemic effect is not manifested in healthy people.
An increase in the sensitivity of peripheral receptors for insulin and the utilization of glucose by cells was noted. Reduces the production of glucose by the liver, by inhibiting glycogenolysis and gluconeogenesis. The drug inhibits the absorption of glucose in the digestive tract.
Metformin is characterized by stimulation of glycogen synthesis, influence on glycogen synthetase. Increases the transport capacity of various types of membrane glucose transporters. Also, the drug favorably affects the metabolism of lipids: reducing the content of total cholesterol, TG and LDL. During the use of metformin, patients maintain a stable weight or moderately reduced.
As a result of intake, there is a complete absorption of the active substance from the digestive tract. Eating food can reduce and delay this process. Moreover, the absolute bioavailability of metformin is 50-60%. The maximum concentration of the component in the plasma composition is found after 2.5 hours.
In the body, metformin is accelerated in the tissues, practically without binding to plasma proteins. The drug is slightly metabolized. Excretion occurs with the help of kidneys.

Indications for use of the drug

The main indications for the use of the drug are:
    treatment of type 2 diabetes in case of diet inefficiency;
    combined therapy with insulin in the presence of a pronounced degree of obesity, which is accompanied by a secondary resistance to insulin.

Contraindications for use

It is not recommended to take Metformin when:
    diabetic ketoacidosis, precoma and coma;
    violations of kidney and liver function;
    various diseases in acute form;
    trauma and surgical operations;
    chronic alcoholism, severe alcohol poisoning;
    lactation, pregnancy;
    lactic acidosis;
    period 2 days before and after radioisotope or X-ray studies suggesting the introduction of iodine-containing contrast medium;
    adherence to a hypocaloric diet;
    sensitivity or intolerance of the drug.
Also, one should refrain from using medication for patients aged 60 years and engaged in heavy physical work with a high risk of developing lactic acidosis.

Side effects

In the treatment of this drug, side effects may occur in the form of disturbances in the digestive system, for example: nausea, vomiting, smack of metal, loss of appetite, diarrhea, flatulence and so on. Usually these symptoms occur at the beginning of therapy and subsequently disappear on their own.
Also, deviations in metabolism in the form of lactic acidosis, which requires the withdrawal of treatment, are not excluded. Prolonged reception of Metformin can cause hypovitaminosis B12. In addition, the likelihood of developing megaloblastic anemia and skin rash remains.

Metformin tablets, instructions for use (Method and dosage)

As the instruction on Glukofazh informs, the dosage of a preparation is selected individually and depends on a parameter of a glucose in structure of a blood.
In this case, the instructions for use Metformin 1000 mg, glucosulfate 850 and 500 mg at the beginning of treatment recommends taking a daily dose of 500-1000 mg. After 10-15 day therapy, a gradual increase in the dose is allowed, given the level of glycemia. On average, the maintenance daily dose is 1.5-2 g, but not more than 3 g. In order to reduce the side effects associated with the work of the digestive tract, the daily dose is divided into 2-3 doses.
These tablets are recommended to be taken simultaneously or immediately after a meal in its entirety. The duration of therapy is chosen individually. Taking this medication for weight loss, you need the supervision of a specialist.

Overdose

While taking Metformin, 850 mg of cases of overdose were not observed. However, it is possible to develop lactic acidosis. For early symptoms of this disorder are characterized by: nausea, vomiting, diarrhea, pain in the muscles and abdomen, fever and so on. Complicated cases can be accompanied by increased respiration, dizziness, impaired consciousness and development of coma.
When lactic acidosis occurs, Metformin should be discontinued immediately, and the concentration of lactate should be determined in a hospital setting, which will make it possible to clarify the diagnosis. In the future, it is possible to use hemodialysis, which allows to withdraw lactate and the components of the medicine from the body. Then symptomatic therapy is performed.

Interaction

The simultaneous use of this drug and danazol may lead to the development of hyperglycemia. If this combination is necessary, correction of dosing and control of the level of glycemia are required.
Taking high doses of chlorpromazine increases glycemia, reducing the release of insulin. Any hormonal drugs lower glucose tolerance, increasing glycemia, can cause ketosis.
The combination with "loop" diuretics preserves the risk of lactic acidosis due to functional renal failure.
Stimulants of β2-adrenergic receptors are able to increase the glucose content of the blood. This requires the control of glycemia, possibly the appointment of insulin. The combination of glucosulphide and derivatives of sulfonylurea, insulin, acarbose, salicylates intensify hypoglycemic action.

Storage conditions

For storage of tablets is intended a dark, cool place, inaccessible to children.

Shelf life

Shelf life Metformin 500 and 850 mg is 5 years, Metformin 1000 mg can be stored for 3 years.

Metformin and alcohol

It is established that alcohol can cause the development of lactic acidosis in acute alcohol intoxication. To aggravate the situation may be the presence of liver failure, fasting or compliance with a low-calorie diet. Therefore, in this period it is necessary to refrain from combinations with ethanol.

Metformin for weight loss

It should be noted that this drug is very popular among slimming people. However, doctors' reviews report that such a method of combating obesity is very dangerous and can cause serious complications. Nevertheless, it is this method that is discussed in various forums where users are interested in - how to take Metformin for weight loss?
However, some people recommend taking Metformin 500 mg, explaining that such a dosage will be enough to "start metabolic processes." Others on the contrary recommend Metformin 850 mg, since a higher dosage "will only speed up the process."
It is interesting that the reviews when losing weight with the help of this drug do not contain descriptions of specific results. But at the same time there are reports of worsening of general health, development of abdominal pain, nausea and even vomiting. Therefore, experts advise to start monitoring their nutrition, which should be full. It is necessary to exclude from the diet sweet, flour and fat and increase physical activity.

Reviews of Metformin

In most cases, the discussion of this drug is related to its use for weight loss. At the same time, some reviews of those who lose weight about Metformin report that they were recommended by the doctor, since diet and exercise did not help to remove excess weight. Other users are interested in how to take this medicine to quickly lose those extra pounds. In addition, you can find stories of patients who took these pills in order to restore reproductive function.
However, the use of the drug for such purposes is far from always effective. Moreover, both reviews of doctors and patients contain information about the development of serious pathologies against the background of similar experiments.
Reviews of Metformin for weight loss also do not describe the specific results. Although patients who take medicine for diabetes mellitus, they note its effectiveness and a gradual decrease in body weight.