Metformin long tabs 750mg #60

Metformin long user manual

You can buy Metformin long here

See also - Metformin

Composition

Tablets, which have a prolonged action, contain 500 or 750 mg of active substance - metformin hydrochloride.
Additional components: carmellose sodium, hypromellose 2910 and 2208, MCC, magnesium stearate.

Form of issue

Metformin Long is available in the form of long-acting tablets, which are packaged in 15 pieces in blisters, 2 or 4 blisters in a package.

pharmachologic effect

The drug has a hypoglycemic effect.

Pharmacodynamics and pharmacokinetics

Metformin is a biguanide with a hypoglycemic effect, capable of lowering the concentration of glucose in the blood plasma. However, it does not stimulate the production of insulin, so it does not cause hypoglycemia. During treatment peripheral receptors become more sensitive to insulin, glucose utilization by cells is increased. The synthesis of glucose by the liver is reduced due to inhibition of glycogenolysis and gluconeogenesis. Delayed absorption of glucose in the digestive tract.
The active component of the drug stimulates the production of glycogen by affecting glycogen synthase. Increases the transport capacity of any membrane glucose transporter.
In the treatment of metformin patients retain weight or notice a moderate decrease. The substance favorably affects the metabolism of lipids: reducing the level of total cholesterol, triglycerides and LDL.
For tablets of prolonged action, slow suction is characteristic. Therefore, the therapeutic effect is maintained for at least 7 hours. Absorption of the drug is not dependent on food and does not cause cumulation. There is a slight binding to plasma proteins. Metabolism occurs without the formation of metabolites. Removal of components occurs in an unchanged form with the help of kidneys.

Indications for use

Metformin Long is prescribed for type 2 diabetes mellitus in adult patients with obesity in cases of ineffectiveness of diets and physical exertion like:
    monotherapy;
    combined treatment with other hypoglycemic drugs or insulin.

Contraindications for use

The drug is not prescribed when:
    sensitivity to metformin and other components;
    diabetic ketoacidosis, precoma, coma;
    impaired or insufficient kidney or liver function;
    acute forms of various diseases;
    extensive injuries and operations;
    chronic alcoholism, alcohol intoxication;
    pregnancy;
    lactic acidosis;
    use 48 h before or after radioisotope or X-ray studies suggesting the introduction of iodine-containing contrast medium;
    hypocaloric diets;
    age less than 18 years.
Caution in the appointment of this drug should be shown for elderly patients, people performing heavy physical work, since this can cause the development of lactic acidosis, in the treatment of lactating women.

Side effects

During therapy with the drug, it is possible to develop lactic acidosis, megaloblastic anemia, decrease the absorption of vitamin B12.
Also, disturbances in the work of the nervous system are not excluded - a change in taste, activity of the gastrointestinal tract - nausea, vomiting, pain, diarrhea, loss of appetite. Typically, these symptoms are worried at the beginning of treatment and gradually go away. To prevent their development, patients are recommended taking metformin together or immediately after meals.
In rare cases, deviations in the activity of the liver and bile, the manifestation of skin allergic reactions are possible.

Instructions for use Metformin Long (Method and Dosage)

Tablets are intended for ingestion in a general form with a small volume of fluid. It is recommended to do this daily during dinner.
As the instruction on application informs, the choice of dosage of tablets of the prolonged action is carried out individually for a particular patient, taking into account the blood glucose concentration indices.
Metformin Long 750 mg and 500 mg can be prescribed both as a mono-and combination therapy. It is important to strictly follow the prescribed dosages and regularly monitor blood sugar levels.

Overdose

The use of metformin in a dosage of less than 85 g does not cause the development of hypoglycemia. But the likelihood of developing lactic acidosis persists.
When symptoms of lactic acidosis occur, the medication should be stopped immediately, the concentration of lactate should be determined in a hospital setting, with the diagnosis clarified. The effectiveness of the procedure for excretion of lactate and metformin from the body with the help of hemodialysis was noted. Also, concomitant symptomatic therapy is performed.

Interaction

The development of lactic acidosis can cause a combination of the drug with iodine-containing radiopaque agents. Therefore, 48 hours before and after a radiological study using iodine-containing radiopaque, the abolition of Metformin Long is recommended.
Simultaneous use of indirect hyperglycemic effect with drugs - hormonal agents or tetracosactide, as well as with β2-adrenomimetics, danazol, chlorpromazine and diuretics - can affect the concentration of glucose in the blood. Therefore, you need to monitor its performance, and if necessary, adjust the dosage.
In addition, in the presence of renal failure diuretics contribute to the development of lactic acidosis. The combination with derivatives of sulfonylurea, acarbose, insulin, salicylates often causes hypoglycemia.
Combinations with amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim and vancomycin, which are secreted in the renal tubules, compete with metformin for tubular transport, which increases its concentration.

Storage conditions

For storage of tablets is intended a dark, cool place, inaccessible to children.
Shelf life - 3 years.

Alcohol

Drinking alcohol increases the likelihood of developing lactic acidosis in acute alcohol intoxication. Strengthening of the effect was noted at starvation, observance of a low-calorie diet, presence of liver failure. Therefore, from the use of alcohol during treatment should be abandoned.

Reviews of Metformin Long

Quite often, patients leave feedback about the glucoside Long 750 mg, since it is this dosage that is prescribed in the treatment of type 2 diabetes in its middle stage. In this case, most patients note the sufficient effectiveness of the drug. Often there are reports that when this medicine was taken by diabetics with a high body weight, then subsequently they noticed a moderate weight loss to more acceptable indicators.
As for Metformin xr 500, a drug in such dosage can be prescribed at the initial stage of treatment. In the future, a gradual increase in the dose before the selection of the most effective.
It should be noted that any hypoglycemic drugs can be prescribed only by a specialist. In addition to competent drug treatment the doctor will recommend changes in diet, exercise, which should be an integral part of the life of people suffering from diabetes. Only such an approach will ensure a normal quality of life and not so acutely feel all the undesirable symptoms of this disorder.