Piroxicam Verte gel 1% 50gr

Piroxicam Verte user manual

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Composition

In one gram of gel Piroxicam contains 0.5 g of the same substance. Additional components: ethanol 95%, carbomer, methyl parahydroxybenzoate, trolamine, propylene glycol, water.

Form of issue

Transparent yellow gel with a characteristic odor; possibly the presence of air bubbles. 10, 15, 20, 25, 30 or 50 grams of gel in a jar of darkened glass, one in a pack of cardboard. 30 or 50 grams of gel in an aluminum tube, one tube in a pack of cardboard.

pharmachologic effect

Non-steroidal anti-inflammatory drug.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Nonsteroidal anti-inflammatory agent from the group of oxycam. Has anti-inflammatory, analgesic and antipyretic effect. Inhibits the enzyme cyclooxygenase, which leads to a slowdown in the biosynthesis of prostaglandins from arachidonic acid molecules. When systemic use suppresses pain syndrome. Inhibits the aggregation of platelets.
With external use, it weakens or reduces the severity of inflammation and pain in the joint region during movement and at rest, stops the morning stiffness and swelling of the joints, helps increase the amplitude and volume of movements in the joints. The analgesic effect is fixed in half an hour after oral administration. The anti-inflammatory effect is observed after 5-7 days. After a single dose, the effect lasts for a day.

Pharmacokinetics

Well absorbed from the intestine. The maximum concentration in the blood is reached after 4 hours. Binding to plasma proteins reaches 99%. Penetrates through the placenta and is secreted by lactation. Metabolized in the liver due to the reactions of hydrolysis and conjugation.
It is excreted unchanged in the form of derivatives, mainly kidneys and in small amounts with feces. Half-life is about two days.
In patients with liver damage, this period may increase.

Indications for use of Pyroxicam verte

Indications for use of Piroxicam in the form of capsules (tablets) and gel:
    articular syndrome (osteoarthritis, rheumatoid arthritis, gout, ankylosing spondylitis);
    pain in the spine, myalgia, neuralgia, traumatic inflammation.

Contraindications

Use is contraindicated when:
    gastrointestinal diseases that can cause bleeding (Crohn's disease, gastrointestinal cancer, ulcerative colitis, diverticulitis);
    ulcer of the organs of the gastrointestinal tract, perforations or bleeding, including in the anamnesis; inflammatory diseases of the digestive system; active peptic ulcer;
    joint application with other agents from the group of non-steroidal anti-inflammatory drugs;
    simultaneous application with anticoagulants;
    reports from an anamnesis of previous severe allergic reactions, especially skin reactions, such as Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis;
    hypersensitivity to auxiliary components;
    severe renal, cardiac or liver failure;
    pregnancy and lactation;
    children under 14 years.

Side effects

    Reactions from the digestive system: loss of appetite, nausea, stomatitis, epigastric pain, flatulence, diarrhea or constipation, bleeding gums, erosive and ulcerative changes in the digestive tract with possible complications in the form of bleeding and perforations, jaundice, temporary increase in liver transaminases , necrosis of the liver with possible fatal outcome. These side effects usually develop with prolonged use of the drug at a dose of more than 30 mg per day.
    Reactions from the hematopoietic system: anemia, leukopenia, thrombocytopenia, eosinophilia.
    Reactions from the metabolism: hypo- or hyperglycemia, hyperkalemia, weight changes, transient increase in the concentration of creatinine and residual nitrogen, uremia in the background of hyperkalemia.
    Reactions from the nervous system: sleep disorders, dizziness, drowsiness, headache, depression, nervousness, mood changes, hallucinations, weakness, eye swelling, sensitivity disorders, visual impairment and eye irritation symptoms.
    Reactions from the genitourinary system: acute renal failure, interstitial acute nephritis.
    Allergic reactions: redness, itching, rashes, swelling of the face and hands, pemphigus vulgaris, Stevens-Johnson syndrome, bronchospasm, Lyell's syndrome, urticaria, vasculitis, angioedema, serum sickness.
    Dermatological reactions: onycholysis, photosensitivity, alopecia.
    Local reactions: tenesmus, irritation of the rectum.
    Other reactions: epistaxis.
    Reactions with external application: erythema or pruritus at the site of application.

Instructions for the use of Pyroxicam verte (Method and dosage)

Instructions for use on gel (ointment)

It is recommended to apply three to four times a day rubbing into the affected area.

Overdose

Symptoms: drowsiness, visual impairment, when using large doses, loss of consciousness is possible.
Symptomatic treatment is performed. Piroxicam can not be evacuated from the body by hemodialysis.

Interaction

When combined, Piroxicam may reduce the effect of antihypertensive agents and diuretics.
When combined with potassium preparations and potassium-sparing diuretics, hyperkalemia may develop.
When combined with other non-steroidal anti-inflammatory or glucocorticosteroid agents, the risk of bleeding from the digestive tract increases.
When used together with lithium salts, the content of lithium in the blood increases.
When combined with anticoagulants (tablets), blood clotting changes are possible; with Aspirin - a decrease in the concentration of piroxicam in the blood.
When taking Piroxicam 24 hours before or after using Methotrexate, its concentration in the blood increases and toxicity increases.
When combined with phenobarbital - there may be a decrease in the concentration of Pyroxicam in the blood; with phenytoin - it is possible to increase the concentration of phenytoin in the blood; with Probenecid, cimetidine, Sulfinpyrazone - an increase in the concentration of Pyroxicam in the blood is possible.

Storage conditions

Keep away from children. Store at a temperature of up to 25 degrees in a dark, dry place.
Shelf life - Three years.

special instructions

Looking through the prism of safety, the drug is not a means of choice, if it is possible to use other anti-rheumatic or non-steroidal anti-inflammatory drugs.
Side effects can be reduced by using the lowest effective dose for the shortest period of time needed to monitor clinical outcomes.
Prolonged treatment with the drug can cause liver damage, which requires regular monitoring of the concentration of hepatic enzymes.
Patients with allergic reactions to wheat should not use the drug, since it contains wheat starch as an additional component.

Analogues

Analogues of Pyroxicam: Finalgel, Movalis and others.

Children

Contraindicated for use before the age of 14 years.

In pregnancy and lactation

These conditions are a contraindication for taking the drug.

Reviews of Piroxicam

Reviews of Piroxicam, along with reports of high efficacy, also report frequent adverse effects from taking the drug.
Piroxicam for IVF
It is often used to increase the frequency of implantation of embryos and the onset of pregnancy. Reviews are contradictory.