Senadexine (Senadexinum) #20

Senadexine instruction for use

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The drug Senadexine represents the pharmacological group of medicinal products laxative medicines of plant origin. It is used to relieve stools with constipation of various origins.

Composition and form of release

The drug Senadexine is available in the form of a tablet for oral administration. They have a round shape, a flat-cylindrical surface and a white color. The main active ingredient of the drug is calcium sennosides, its content in one tablet is 70 mg. It also includes auxiliary components:
    Corn starch.
    Microcrystalline cellulose.
    Stearic acid.
    Lactose monohydrate.
    Vanillin.
    Talc.
    Magnesium stearate.
    Methylparahydroxybenzoate.
Tablets Senadixin are packaged in a blister for 10 pieces. A cardboard bundle can contain 1 (10 tablets) or 2 (20 tablets) blisters and instructions for the use of the drug.

Pharmacodynamics and pharmacokinetics

The main active ingredient of the tablets Senadixin is of vegetable origin (Senna herb or Alexandrian leaf). It is represented by various glycosides, mainly anthraglycosides (sennosides A and B). After taking the pill, sennosides pass through the stomach and small intestine unchanged. In the large intestine, under the action of enzymatic systems of bacterial microflora, they are cleaved to active compounds of anthranol and antrons, which have a therapeutic effect. The laxative effect is to reduce the absorption of mineral salts from the lumen of the large intestine. Due to this, the osmotic pressure in it rises and water accumulates, which softens the stool masses. The therapeutic effect does not develop immediately, but 6-10 hours after taking the pill. With prolonged use of Senadexine tablets, its activity may decrease, which is associated with a decrease in the concentration of potassium salts in the body and in the large intestine. The active components of the drug are not absorbed into the systemic circulation. Due to the minimum resin content in the preparation, it has almost no irritant effect on the mucosa of the digestive tract.

Indications for use

The main medical indications for taking Senadexine tablets are chronic constipation and decreased intestinal tone (hypotension) or its absence (atony). Also, as a pathogenetic agent, the drug is used in the complex therapy of diseases requiring softening of fecal masses, such as hemorrhoids, proctitis (inflammation of the rectum), cracks and erosions of the rectal mucosa. Before conducting a diagnostic study of the lower intestine, Senadexine is used as a preparation preparation.

Contraindications

There are a number of pathological and physiological conditions of the patient's body, in which the use of tablets Senadexine is contraindicated, they include:
    Pain sensations in the abdominal region, which have an unidentified origin.
    Violation of the water-electrolyte balance of the patient's body, accompanied by a decrease in the concentration of salts and fluid volume.
    Inflammation of the appendix (appendicitis), rectum (proctitis), peritoneum (peritonitis), small intestine (enteritis).
    Ulcerous lesions of the walls of the structures of the digestive tract (ulcerative colitis, Crohn's disease, peptic erosions of the stomach or duodenum).
    Intestinal obstruction of paralytic origin.
    Uterine bleeding in women (metrorrhagia).
    Gastrointestinal bleeding.
    Injured hernia with localization in the abdomen or groin.
    Inflammation of the urinary bladder (cystitis).
    Age of child up to 1 year.
    Hypersensitivity to any of the components of the drug.
With caution, Senadexine tablets are used in children under 6 years of age, as well as with the concomitant pathology of the liver or kidneys. Before using the drug, you should make sure that there are no contraindications.

Dosing and Administration

Tablets Senadixin intended for oral administration. They are taken in the evening before going to sleep entirely, do not chew and drink with enough water. For adults and children over 12 years of age, the average therapeutic dosage is 1-2 tablets, if necessary, in the absence of the necessary therapeutic effect, the dose can be increased to 3 tablets (this dose is taken no sooner than a few days after the last reception of the Senadexine tablets). Children aged 6 to 12 years are recommended ½ tablets, and at the age of 1 to 6 years - 1/3 of the pill.

Side effects

Against the background of taking Senadexine tablets, it is possible to develop negative pathological reactions from various organs and systems:
    The digestive system - nausea, periodic vomiting, severe diarrhea, laying melanin on the mucosa of the intestinal wall.
    The cardiovascular system is a marked decrease in the level of systemic arterial pressure up to the vascular collapse, which is associated with loss of fluid.
    The nervous system is convulsions of the striated skeletal musculature, which develop due to the loss of mineral salts.
    The urinary system is the appearance of protein (albuminuria), blood (hematuria) in the urine, and its discoloration.
    Metabolism is the loss of salts and fluid from the body, which occurs with prolonged use of the drug in a high therapeutic dosage.
    Allergic reactions - a rash on the skin, its periodic itching.
The appearance of pathological adverse reactions after the start of taking Senadexine tablets is the basis for discontinuing the use of the drug and visiting a doctor.

special instructions

Before you start taking Senadexinum tablets, you should read the instructions carefully. There are several specific indications regarding the use of the drug, which include:
    Prolonged intake of tablets can provoke a violation of the water-electrolyte balance of the body (loss of water and salts with feces).
    The possibility of using the drug for pregnant women and breastfeeding women is determined by the doctor individually according to strict medical indications, which is associated with a high probability of developing negative pathological reactions.
    Simultaneous use of the drug with diuretics significantly increases the risk of dehydration (dehydration) and loss of salts, simultaneous reception of cardiac glycosides increases their effect.
    The immediate effect of the active ingredients of the drug on the functional activity of the cerebral cortex is not excluded, it can reduce the speed of psychomotor reactions and the possibility of concentration of attention.
In the pharmacy network, Senadexine tablets are dispensed without a prescription. If you have any doubts about the indications for the use of the drug, you should consult a medical specialist.

Overdose

If there is a significant excess of the recommended therapeutic dosage of Senadexine tablets, severe diarrhea develops with rapid loss of mineral salts and fluid from the body. In this case, pathogenetic therapy with intravenous administration of solutions of electrolytes is carried out.

Terms and conditions of storage

The shelf life of Senadexine tablets is 2 years. They should be stored in the original factory packaging, dark, dry, inaccessible to children at an air temperature of not more than +20 ° C.