5-NOK tabs 50mg #50

5-NOK instruction for use

Reed more and buy 5-NOK antibiotic here

Composition

One tablet of the preparation 5-NOK includes 50 mg of nitroxoline.
Additional substances: lactose monohydrate, calcium hydrogen phosphate, corn starch, colloidal silicon dioxide, talc, povidone K25, magnesium stearate, crospovidone.
Sheath composition: povidone K25, acacia gum, sucrose, sodium carmellose, talc, colloidal silicon dioxide, corn starch, titanium dioxide, calcium carbonate, yellow dye.

Form of issue

Orange biconvex tablets of round shape, shiny.
50 tablets in a vial - one bottle in a pack of cardboard.

pharmachologic effect

Antibacterial action.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

From Internet users often the question is "this drug - an antibiotic or not?". 5-NOK is an antibiotic, a chemical derivative of 8-hydroxyquinoline.
Has a wide range of effects on infectious agents. Selectively suppresses the biosynthesis of bacterial DNA, creates complexes with metal-containing enzymes of the microbial cell.
Valid for:
    grampositive microorganisms of the genera Staphylococcus, Streptococcus, Enterococcus, Corynebacterium, as well as Bacillus subtilis;
    gram-negative microorganisms of the genera Proteus, Klebsiella, Salmonella, Shigella, Enterobacter, as well as Escherichia coli, Neisseria gonorrhoeae, Haemophilus influenzae;
    other microorganisms - Trichomonas vaginalis, Mycoplasma hominis, Mycobacterium tuberculosis, Ureaplasma urealyticum.
It is also effective against a number of fungi (mold fungi, dermatophytes, candida).

Pharmacokinetics

Well absorbed from the intestine. The highest plasma concentration is achieved approximately 2 hours after ingestion.
Nitroxoline is transformed in the liver. It is excreted mainly with urine in its original form and slightly with bile. There is a high content of conjugated and unconjugated drugs in the urine.

Indications for use of 5-NOK

Acute, chronic and often recurrent urinary tract infections, from which 5-NOK tablets are helpful, are one of the most common problems in the population. Listed below are the indications for use (from which the medicine) 5-NOK:
    epididymitis;
    cystitis;
    pyelonephritis;
    urethritis;
    infected carcinoma or prostate adenoma;
    prevention of postoperative infectious complications during surgical interventions on the urogenital tract, as well as in the treatment and diagnostic manipulations;
    prevention of recurrent infections of the urogenital tract.

Contraindications

    cataract;
    severe kidney or liver failure;
    age less than 3 years;
    pregnancy or lactation;
    hypersensitivity to the constituents of the drug or quinolines.

Side effects

    Digestive disorders: vomiting or nausea (can be prevented by taking the drug while eating), increasing the level of hepatic transaminases.
    Disorders from the circulation: tachycardia.
    Disorders from the nervous activity: headache, ataxia, polyneuropathy, paresthesia.
    Allergic reactions: a rash on the skin.
    Other reactions: increased uric acid concentration in plasma, thrombocytopenia.

Instructions for use 5-NOK (Method and dosage)

The medicine must be taken before meals.

Tablets 5-NOK, instructions for use

The usual dosage for adults is 400 mg per day (including cystitis), 2 tablets 5-NOK four times a day. The highest dose is 800 mg per day. These dosages are also applicable for the administration of 5-NOK in cystitis.
The average dose for children from 5 years of age is prescribed at a rate of 200-400 mg per day, which are divided into 4 divided doses; and for patients 3-5 years - at a rate of 200 mg per day, which are divided into 4 doses.
The average duration of the treatment cycle is 15-30 days, if necessary, treatment is continued with intermittent cycles (15 days per month).
Patients with moderate failure of the kidney or liver, the drug is recommended to use 50% of the indicated daily dosage - 1 tablet four times a day.

Overdose

There are no reliable reports of acute drug intoxication.

Interaction

With the combined use of nitroxoline with tetracyclines, the summation of their effects is revealed, and with Levorin and Nystatin, potentiation of the action.
When combined with antacids containing magnesium, the absorption of nitroxoline is slowed down.
Nitroxoline weakens the therapeutic effect of nalidixic acid.
To prevent the neurotoxic effect, it is forbidden to combine the intake of nitroxoline with nitrofurans.
The drug should not be used together with drugs that include hydroxyquinolines.

Storage conditions

Store at room temperature. Keep away from children.
Shelf life - 5 years.

special instructions

When using drugs in patients with impaired renal function, due to the possible accumulation of nitroxoline in the body, regular medical monitoring is necessary.
It is forbidden to prescribe courses of therapy lasting more than 4 weeks without examining the function of the kidneys and liver.
Against the background of therapy with nitroxoline, urine can be colored in an intense orange color.

Children

The average dose for children from 5 years of age is prescribed at a rate of 200-400 mg per day, which are divided into 4 divided doses; and for patients 3-5 years - at a rate of 200 mg per day, which are divided into 4 doses.

In pregnancy and lactation

The drug is not allowed during pregnancy or lactation.

Reviews about 5-NOK

Reviews of the 5-NOK report that the drug has long proven itself in the treatment of cystitis and pyelonephritis. Side effects almost never occur.