Dazolic tabs 0.5gr #10

Dazolic instruction

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Composition

Each tablet as a component contains:
    Ornidazole (the main active substance of Dazolic tablets) - 0.5 mg;
    starch;
    microcrystalline cellulose (MCC);
    sodium lauryl sulfate;
    polyvinylpyrrolidone K90;
    purified talc;
    magnesium stearate;
    colloidal silicon dioxide;
    sodium starch glycolate A;
    eudrazhit E-100;
    titanium dioxide;
    polyethylene glycol 6000;
    isopropyl alcohol;
    acetone;
    purified water.

Form of issue

Biconvex tablets are round in shape white or close to white. Each piece is covered with a sheath and has a characteristic risk on one side. Tablets are placed in blisters of aluminum foil or PVC, 10 pieces each. The cardboard package accommodates 1 or 5 contour-cell plates.

Pharmacological action

Dazolic is an antibiotic of an antiprotozoal character, that is, the main pharmaceutical effect of the drug is directed to the destruction of microorganisms, which belong to the simplest. In particular, the active components of the drug disrupt the structure of chains of deoxyribonucleic acid, the main carrier of genetic information necessary for normal vital activity and reproduction in living cells. Antibiotic properties are effective for a wide range of microorganisms, which include:
    Giardia lamblia (intestinal lamblia);
    Trichomonas vaginalis (vaginal trichomonas);
    Entamoeba histolytica (dysentery amoeba);
    Clostridium perfringens (clostridium perfringens);
    Bacteroides fragilis (bacteroids fragilis);
    Fusobacterium nucleatum (Fusobacterium nucleoid or Plaut's stick).
It should be noted that the last three types of harmful microorganisms refer to an anaerobic microflora, that is, for normal life of such cells, oxygen is not needed. As a rule, these families cause particularly severe damage to the deep structures of the human body, which sometimes lead to gangrene, as an absolute therapeutic indication.

Pharmacodynamics and pharmacokinetics

The main constituent elements are fast and complete enough (bioavailability of the drug is good 90 percent) are absorbed from the gastrointestinal tract after oral administration. The maximum plasma concentration is achieved after 1-2 hours, depending on individual metabolic parameters. At least 15 percent of biological substances Dazolic binds in the blood with its proteins. 13 hours after taking the tablets, the constituent components are able to penetrate the blood-brain barrier.
The antibiotic drug is predominantly excreted by the kidneys - about 60-70 percent of all metabolic products. 20-25 percent is allocated by stool. 5 percent of the accepted dose is found in the unchanged form in urine and feces.

Indications for use

    trichomoniasis;
    amebiasis (including both intestinal forms of the disease, for example, amoebic liver abscess, and dysentery);
    giardiasis;
    prevention of anaerobic infections (often used in the conservative phase of treatment for operations on the colon and in gynecology).

Contraindications

    hypersensitivity, acquired or hereditary intolerance, idiosyncrasy in relation to the constituent components of the drug;
    periods of pregnancy (especially in the first trimester) and lactation (in particular breastfeeding);
    organic pathology of the central nervous system.

Side effects

During the course of drug therapy, Dazolic may have the following undesirable consequences:
    From the gastrointestinal tract: dyspeptic indigestion, nausea, vomiting, diarrhea.
    From the central and peripheral system: headache, dizziness, impaired consciousness, rigidity of individual muscles, intentional tremor, cramps that resemble epileptic seizures, impaired coordination of movement, especially fine motor skills, mixed or sensory-peripheral neuropathy.

Dazolic, instructions for use (Method and dosage)

Instructions for use Dazolic slightly different dosage and scheme of treatment, depending on the primary disease, against which conservative therapy with antibiotic.
With trichomoniasis, use a dose of 500 mg twice a day (two tablets for 24 hours) for 5 days. In pediatric practice, the amount of pharmaceutical preparation is calculated based on body weight - 25 mg / kg and take the pill only once a day.
In the treatment of amoebic infection, the amount of the drug depends on the form of the disease. So, for dysentery caused by Entamoeba histolytica, the dosage is 1.5 g / day for patients weighing about 35 kg or more. For patients with a lower body weight, 40 mg / kg daily is used as a single dose. The duration of such medication is 3 days.
If amoebiasis is extra-intestinal, then the drug is taken 2 times a day in the morning and in the evening, and the dosage depends on the age:
    children over 12 years and adults of 500 mg;
    age category from 7 to 12 years - 375 mg;
    from 1 year to 6 years - 250 mg;
    newborns under 1 year - 125 mg.
The course of such treatment should last from 5 to 10 days, the exact scope is determined by the attending physician depending on individual indicators during conservative therapy.
Giardiasis is treated according to the following scheme - for the adult age category and in pediatric practice, patients weighing 35 kg or more - 1.5 g twice daily. If the weight is less than 35 kg, then as with dysenteric amoeba, the dosage is 40 mg / kg once a day. Duration of treatment is 1-2 days.
Preventive therapy of anaerobic infections is made in this way - 0.5-1 g once before the operation (the exact dosage is set by the operating surgeon from the corresponding body parameters), and then, after the operation, 500 mg twice a day for 3-5 days.

Overdose

Symptoms of increased concentration of active components in serum:
    epileptiform convulsions;
    depression;
    peripheral neuritis.
Specific antidote for the drug Dazolic in pharmaceutical practice does not exist, therefore, when an overdose of active ingredients is used symptomatic treatment. Thus, for example, diazepam, a soothing pharmaceutical preparation of central type of action belonging to the benzodiazepine series of tranquilizers, is used to arrest convulsive seizures.

Interaction

Dazolic greatly enhances the therapeutic effects of coumarinic anticoagulants, which can manifest itself in the form of point hemorrhages, hemorrhagic rash or purpura.
Ornidazole increases the duration of the miorelaxing action of Vecuronium Bromide.

Storage conditions

Dazolic should be stored out of reach of children and protected from direct rays of light at room temperature (18-22 degrees Celsius), but not more than 25 degrees Celsius.
Shelf life - 3-5 years.

special instructions

With trichomoniasis, conservative therapy should be performed simultaneously with both sex partners, since the vaginal trichomonas are transmitted through sexual contact.
In no case should you break the drug regimen and independently reduce the course of conservative therapy prescribed by your doctor, as in the case of sanation with any other antibiotic. Such actions can lead to incomplete pharmaceutical effects and the development of resistance to Dazolic (and the whole group of antibiotics based on ornidazole) in harmful microorganisms, which is fraught with serious consequences. So in the case of amoebic dysentery, stronger antibiotics will be prescribed, the spectrum of side effects is much wider than that of this drug, which will make the drug treatment more debilitating and prolonged.
Pharmaceutical preparation can significantly affect the coordination of movements and fine motor skills, cause mental disorders, therefore, during conservative treatment should abandon the management of the car or other potentially dangerous mechanisms.

Children

The drug can be used in pediatric practice since the neonatal period (there are cases of infection of children with vaginal trichomonad after passing through the infected birth canal), but strict dosages of Dazolic are prescribed, since in view of the physiological imperfection of the excretory systems of the young organism, the possibility of developing an overdose in children is much higher.

Dazolic and alcohol

Alcohol and ethanol exchange products are compatible with the pharmaceutical preparation, its constituent components do not inhibit acetaldehyde genase and do not contribute to the accumulation of toxic substances, therefore there are no disulfiram-like reactions, however, alcohol consumption during the course of conservative treatment, as well as in combination with other antibiotics, is not recommended.

In pregnancy and lactation

The drug is contraindicated for use during periods of lactation and pregnancy, especially in the first trimester, as it can irreversibly affect the vital systems and organs of the developing child.

Reviews about Dazolic

Reviews on Dazolic in a variety of pharmaceutical forums are mostly positive, because the antibiotic copes with harmful microorganisms in a short time and allows you to quickly restore full working capacity and return to the system. Also, people who underwent treatment with this pharmaceutical drug note an unusually small amount of undesirable effects of therapy, which also manifest themselves far from all the cases of the conservative course of sanation by Dazolic.
Almost for the same reasons, the antiprotozoal drug has become popular with both the treating physicians of the therapeutic hospitals and the qualified pharmacists. He is boldly appointed in the pediatric department and adults, since the strength of the antibiotic effect allows you to treat a wide range of pathologies and destroy harmful microflora with minimal unwanted reactions.
It is also worth noting that it is not easy to achieve an excessive plasma concentration of active components in blood plasma, because Dazolic has a wide scope of application, which can not help giving an extra point in front of other antiprotozoan antibiotics.