Flemoxin Solutab tabs 500mg #20

Flemoxin Solutab instruction for use

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Composition

The composition of dispersible (water-soluble) tablets includes amoxicillin in the form of amoxicillin trihydrate (Amoxicillin trihydrate), microcrystalline and dispersible cellulose, vanillin, crospovidone, flavorings (lemon and mandarin), magnesium stearate, saccharin.

Form of issue

Tablets Flemoxin Solutab dispersible:
    125, 250, 500 or 1000 mg package number 20 (blisters of 5 pcs., 4 blisters in the package);
    125 mg package number 14 (7 pcs. Blisters, 2 blisters per pack).
Tablets are oval, white or white with a yellowish tint of color, with a dividing risk on one side, and a numeric designation (231, 232, 234 and 236) and the manufacturer's logo on the other.

pharmachologic effect

Antibacterial, bactericidal.

Pharmacodynamics and pharmacokinetics

Amoxicillin is a semisynthetic β-lactam antibiotic of the penicillin group with a broad spectrum of antimicrobial activity.
Bactericidal properties of the drug are due to the ability to suppress transpeptidase, disrupt the production of peptidoglycan (supporting protein cell walls) during periods of division and growth, to provoke the lysis of microorganisms.
It is active against Gram (+) aerobes, including Staphylococcus spp. (except for penicillinase-producing strains) and Streptococcus spp. (including Str.pneumoniae and faecalis); Gram (-) aerobes (gonococci, meningococci, intestinal and hemophilic rods, proteus mirabilis, individual strains of Klebsiella, Shigella and Salmonella, and also against H. pylori.
It is ineffective against P.rettgeri and vulgaris protease strains (indolpositive), serrations, pseudomonads, enterobacteria, morganella morgani. Resistant to the action of amoxicillin mycoplasma, rickettsia and viruses.
A feature of the dosage form is that the tablets are readily dispersible in water to form a dispersion. Thanks to this, the drug is absorbed quickly and completely (more than 93% of the dose taken) from the digestive canal.
Eating does not affect the absorption of the substance. TCmax - within the range of 60 to 120 minutes. With the use of dispersible tablets, the plasma concentration of amoxicillin is higher than when insoluble forms of the drug are administered. The active substance is resistant to acids.
TCmax when taking 500 mg of amoxicillin - 120 minutes. When taking a twice or twice smaller dose of the drug, the Cmax index also changes twofold.
About 20% of the dose of amoxicillin is associated with plasma proteins. The substance in therapeutically effective concentrations penetrates well into the bone tissue, mucous membranes, sputum and intraocular fluid. Its concentration in the bile is 2-4 times higher than the plasma concentration, in the amniotic fluid - from 25 to 30% of the plasma concentration in the body of the pregnant woman.
Through GEB, amoxicillin passes poorly, but with inflammation of the brain membranes, its concentration in the cerebrospinal fluid is about ⅕ from the plasma concentration.
The substance is partially metabolized, most metabolic products are inactive against pathogenic microflora.
Excretion is carried out by the kidneys. In patients with healthy kidney T1 / 2 - from 60 to 90 minutes, in children under the age of six months (including preterm and newborns) - from 3 to 4 hours. If there is a violation of liver function, the indicator does not change, if the kidney function is impaired, it can increase up to 8.5 hours (this is T1 / 2 amoxicillin in anuria).

Indications for use: from what tablets Flemoxin Solutab?

Indications for use of the drug are bacterial infections of the organs of the external respiration system (angina, pneumonia, bronchitis, pharyngitis, sinusitis, acute inflammation of the middle ear), urogenital system organs (pyelonephritis, pyelitis, cystitis, urethritis, cervicitis, endometritis), skin and / or soft tissues (impetigo, erysipelas, secondarily infected dermatoses), digestive system organs and abdominal infections (angiocholitis, peritonitis, typhoid fever, cholecystitis, salmonellosis, dysentery, salmonella carriage) if they are caused by sensitive to Flemoxin bacteria.

Flemoxin - why is it used in pediatrics?

Flemoxin Solutab is the penicillin group most commonly used in pediatric practice. Most often it is prescribed for bacterial infections of the respiratory system.
Experience of practical application proves the high efficiency of Flemoxin for sinusitis, acute neognome otitis, bronchitis, bronchopneumonia, tonsillitis, tonsillitis.
The drug is safe, well tolerated by small patients of any age and - not least, when it comes to treating children - has excellent organoleptic properties.

Contraindications

Flemoxin is not prescribed for hypersensitivity to amoxicillin, other β-lactams or auxiliaries of tablets.
Relative contraindications to antibiotic Flemoxin Solutab:
    lymphocytic leukemia;
    Infectious mononucleosis;
    kidney failure;
    abnormal gastrointestinal tract history (especially associated with the use of antibiotics colitis);
    pregnancy;
    lactation;
    the period of breastfeeding;
    polyvalent hypersensitivity to foreign to chemical substances (xenobiotics).

Side effects

Side effects are manifested as:
    nausea, changes in taste, diarrhea, vomiting, moderate increase in the activity of liver enzymes (sometimes), hemorrhagic and pseudomembranous colitis (extremely rare);
    interstitial nephritis (extremely rare);
    Hemolytic anemia, neutropenia, agranulocytosis, thrombocytopenia.
When using the drug in the form of dispersible tablets, there were no adverse events on the part of the nervous system.
The use of the drug may be accompanied by the development of hypersensitivity reactions, which are expressed as a rash (mainly specific makulopapular), multiforme exudative erythema (rarely), angioedema and anaphylactic shock (in exceptional cases).

Tablets Flemoxin Solutab: instructions for use

How to take adult pills Flemoxin?

The drug is taken orally, without becoming attached to the time of ingestion.
The tablet can be dissolved in 20 ml of water until a syrup is obtained or in 100 ml of water until a suspension is obtained, can be swallowed whole or taken in a crushed form.
With infections of the lung and medium-heavy course, 250 mg tablets take 2-3 pills. 2 r. / Day, tablets 500 mg - 1-1.5 pcs. 2 r. / Day, a tablet of 1000 mg - in a half of 3 r. / Day.
In the treatment of serious diseases, as well as infections with hard-to-reach foci, it is preferable to take the drug three times during the day.
The daily dose of an antibiotic for severe infections, relapses and chronic pathologies is 1.5-2 tab. 500 mg 3 times a day.
In the case of acute gonorrhea without complications, a single administration of Flemoxin with Probenecid (dose, respectively, 3 and 1 g) is indicated.
With infections of severe course and chronic pathologies, the treatment regimen is selected taking into account the characteristics of the clinical picture of the disease.
In cases of kidney damage, when Clcr is between 15 and 40 ml / min, the interval between tablets should be increased to 12 hours. If the Clcr score does not exceed 10 ml / min, the dosage of amoxicillin should be reduced by 15-50%. With anuria, the highest daily dose of amoxicillin is 2 g.

How do I take Flemoxin tablets to children?

Children's Flemoxin - a pill with a dosage of amoxicillin 125 and 250 mg. In the instruction for children it is indicated that it is more convenient for a child of younger age to give a syrup or suspension, older children can swallow the whole tablet or pre-chew.
Instruction for the use of Flemoxin for children older than 10 years is similar to the instructions for adults: for infections of the lung and mild-severe course, the child is given 3-4 tab. 125 mg 3 r. / Day.
Flemoxin Solutab for children over 3 years old is prescribed to take 3 tab. 125 mg 2 p. / Day. or 2 tab. 125 mg 3 r. / Day.
Children under 3 years, according to the instructions for use, Flemoxin Solutab 125 mg, tablets give two 2 rubles / day. or one 3 r. per day.
Dosage Flemoxin Solutab for children, which contains 250 mg of amoxicillin is as follows:
    2-3 tab. 2 rubles / day. - patients older than 10 years;
    1 tab. 3 rubles / day. - Patients 3-10 years of age;
    1 tab. 2 rubles / day. or 0.5 tab. 3 rubles / day. - patients younger than 3 years of age.
The daily dose of Flemoxin Solutab for children of all age groups (including children of the first year of life) is from 30 to 60 mg / kg divided into 2 or 3 doses. If the disease is severe or the pathological focus is difficult to access, the drug should preferably be taken at 3 r./day.
In severe infections (including those with hard-to-reach foci), the recommended dose of antibiotic is 60 mg / kg / day, divided into three doses.

Duration of treatment

Duration of the course for infections of the lung and medium-heavy course - from 5 days to 1 week. If the causative agent of the infection is Str. pyogenes, treatment lasts at least 10 days.
For infections of severe course, the drug should be continued for 48 hours after the symptoms have disappeared.

Antibiotic Flemoxin Solutab with angina

Angina is a common acute infectious disease, the local manifestations of which is the destruction of the tonsils (mainly the first and second - the palatines). The most frequent pathogens of angina are B-hemolytic streptococci in group A. Significantly, it is provoked by staphylococci.
Untreated or untreated tonsillitis is complicated by paratonzillitis, nephritis, myocarditis, paratonsillar abscess, tonsiligenic sepsis.
Given the bacterial nature of the disease, it is very important to use antibiotics in a timely manner. If in catarrhal angina in a number of cases, the patient has enough local antibiotics, then with follicular and lacunar angina the doctor necessarily prescribes systemic drugs.
The results of studies and practical experience have shown that penicillin group preparations are the most effective agents for angina.
Advantages of Flemoxin before analogues are:
    unique dosage form (Solutab);
    the presence of tablets with a "child" dosage of the active substance;
    the possibility of using the drug, without being tied to the time of eating.
Adults with angina drug is recommended to take 2 pp. / Day. on 500-700 mg. With angina children use children's Flemoxin Solutab - tablets with a minimum dosage of the active substance. The dose is selected by the doctor depending on the age of the patient and the features of the course of the disease.
After the symptoms of sore throat are reduced (body temperature will decrease, pustules on tonsils disappear, sore throat, lymph nodes become normal), Flemoxin should be continued for at least two more days.
If the treatment is stopped immediately, the risk of recurrence of the disease is high. And the symptoms can manifest with redoubled force.

Use of the drug for sinusitis

Genyantritis is an inflammation of the accessory maxillary sinuses of the nose.
The use of an antibiotic for sinusitis is advisable in the event that the disease is caused by bacteria that are sensitive to its action. When associated with a viral or fungal infection, as well as with allergic sinusitis, antibiotic therapy is not only ineffective, but can also aggravate the course of the disease.
Acute bacterial sinusitis is manifested in the first place:
    hyperthermia (febrile and above);
    violation of nasal respiration and phonation;
    soreness and swelling of the skin in the projection of the maxillary cavities;
    a decrease in smell;
    the presence of irradiating in different parts of the face with pain (pain gradually lose a specific location location);
    symptoms of general intoxication (sleep disorders, headache, aches in the joints, etc.);
    the characteristic color of the pathological secretion from the sinus (its color in bacterial infections usually varies from yellow to dark green).
Selection of an antibiotic is carried out taking into account:
    the results of a microbiological study of the biomaterial taken from the paranasal sinuses and an express test for the staining of the pathogen by the Gram method;
    features of the patient's body;
    possible allergic reactions to the drug;
    presence of concomitant diseases.
If the cause of the disease are staphylococci, streptococci or haemophilus influenza, the most preferable is the appointment of a patient with drugs of the penicillin group.
The use of amoxicillin in bacterial sinusitis (including with complicated forms of the disease) gives a pronounced positive effect in the first 7 days of treatment: the patient decreases / disappears symptoms of body intoxication and pain in the area of ​​the paranasal sinuses, the temperature decreases and nasal breathing is facilitated.
The effectiveness of Flemoxin Solutab is explained by the fact that this drug:
    affects a large number of strains of infectious agents;
    quickly and in high concentrations is absorbed from the digestive tract;
    resistant to the action of gastric juice;
    is available in a convenient form.

Overdose

Symptoms of an overdose Flemoxin Solutab: nausea, diarrhea, vomiting, violation of the water-salt balance.
Treatment: gastric lavage, the appointment of enterosorbents, salt laxatives, the implementation of measures aimed at correcting the balance of water and electrolytes.

Interaction

Phenylbutazone, probenecid, oxyphenbutazone and - to a lesser extent - sulfinpyrazone and ASA inhibit the secretion of antibiotics of the penicillin group, which leads to an increase in T1 / 2 and an increase in the plasma concentration of amoxicillin.
Bactericidal antibiotics (including rifampicin, vancomycin, cephalosporins and aminoglycosides) have a synergistic effect when used in combination with Flemoxin.
With simultaneous administration with individual bacteriostatic agents (sulphonamides, chloramphenicol, etc.) antagonism is possible.
Use with estrogen-containing oral contraceptives may lead to a decrease in the effectiveness of the latter and an increased risk of developing rash bleeding.
The use in combination with allopurin in contrast to the combination of Ampicillin and Allopurin does not increase the incidence of skin reactions.

Storage conditions

Store below 25 ° C.
Shelf life - Five years.

special instructions

The presence in the anamnesis of erythroderma is not a contraindication to the use of the drug.
The possibility of developing cross-resistance with cephalosporins and antibiotics of the penicillin group is not ruled out.
As with other penicillin drugs, superinfection may develop.
Characteristic for pseudomembranous colitis severe diarrhea on the background of drug treatment is the reason for the withdrawal of Flemoxin.
In patients with lymphatic leukemia and infectious mononucleosis, the occurrence of non-allergic exanthema is highly likely.

What is better - Flemoxin or Flemoclav?

Flemoclav is a combined antibacterial preparation manufactured by Astellas Pharma in the form of dispersible tablets.
The basis of the tablets is amoxicillin, but - and this, in what is the difference between it and Flemoxinum, - to enhance its effect, the composition also includes clavulanate (or clavulanic acid) - a substance that inhibits the bacterial enzymes of beta-lactamase.
That is, the Flemoclav is active against amoxicillin-sensitive microorganisms, as well as against strains of bacteria that produce certain chromosomal and most plasmid β-lactamases.
Clavulanate inhibits beta-lactamase II, III, IV and V type, but is inactive with respect to those produced by enterobacteria, Pseudomonas aeruginosa, acinetobacteria, and sera (beta-lactamase type I).
Having high tropicity to the antibiotics of the penicillin group, clavulanate significantly expands the activity spectrum and, consequently, the use of amoxicillin.

Flemoxin Solutab and alcohol

Patients who are prescribed antibiotic therapy, alcohol use is contraindicated.

Flemoxin Solutab during pregnancy

The purpose of the drug in pregnancy and breastfeeding (HS) is possible if the expected effect of its use exceeds the risk of unwanted side reactions.
A small amount of amoxicillin is secreted into breast milk, which can provoke the development of sensitization phenomena in a child on the HS.

Reviews of Flemoxin Solutab

Flemoxin is an effective and safe remedy that treats most types of bacterial infections. The drug helps with cystitis and pyelonephritis, with angina, secondarily infected dermatoses, and he has earned good reviews in genyantritis.
The main advantage of the antibiotic is its acid resistance and high bioavailability, thanks to which amoxicillin reaches its place of action in maximum concentration. The only downside, perhaps, is that it does not affect the strains producing β-lactamase.
The intake of food does not change the pharmacokinetics of amoxicillin and does not affect the effectiveness of the assimilation of the drug, as a consequence - the plasma concentration reaches peak values ​​within an hour or two after taking the tablet / suspension.
Flemoxin is well combined with most other medicines and supplements, and a high profile of the drug's safety allows prescribing it to pregnant women and children.
Reviews of Flemoxin Solutab for children are overwhelmingly good. Many mothers consider it to be the best antibiotic for angina and pharyngitis. However, as in the case of other antibacterial drugs, the effectiveness of treatment depends on how correctly the drug is selected, and for this an agent must be identified.
Flemoxin is disastrous for the majority of microorganisms causing respiratory diseases, which are especially affected by small children, so the manufacturer produces the drug even in a special infant dosage of 125 and 250 mg.
Important in pediatrics is the convenience of use: tablets Flemoxin can be eaten as a sweet, and can be dissolved in water and drunk as a drink with a pleasant fruit taste.