Levolet R tabs 500mg #10

Levolet R user manual

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Composition

One Levolet R tablet contains 256.233 mg. or 512.466 mg. levofloxacin hemihydrate, which corresponds to 250 mg., and 500 mg. active medicinal substance levofloxacin.
As auxiliary compounds, the composition of the preparation includes corn starch, crospovidone, Avicel PH 101 and Avicel PH 102 (MCC), colloidal silica, hypromellose, magnesium stearate.
The coating of the drug contains white dye OY 58900 Opadry (macrogol 400, hypromellose 5 cP, as well as titanium dioxide).
In 100 ml. Levolet R solution contains 512 ml for infusions. active ingredient levofloxacin hemihydrate, as well as auxiliary substances such as water for injections (not more than 100 ml), dextrose (5,000 ml), hydrochloric acid (0.117 ml), and sodium hydroxide (2.857 ml).

Form of issue

The medicine is released in the form of white biconvex tablets (250 or 500 mg) capsular shaped with a "RDY" embossed on one side, coated with a specialized coating.

Levolet R can be a transparent or pale yellow solution for infusions.

pharmachologic effect

This broad-spectrum medicine has antimicrobial as well as bactericidal properties.

Pharmacodynamics and pharmacokinetics

The drug compound, which is part of the drug, blocks topoisomerase II (DNA gyrase) and topoisomerase IV, thereby disrupting supercoiling, which triggers the synthesis and "cross-linking" of DNA breaks. Thus, the drug causes morphological transformations in the cytoplasm, in cell walls, as well as in membranes.
The drug actively fights with anaerobic (Bacteroides fragilis, Veillonella spp.), Aerobic Gram-positive (Staphylococcus spp., Corynebacterium diphtheriae.) And Gram-negative (Escherichia coli, Morganella morganii), as well as sensitive, moderately sensitive and resistant harmful microorganisms.
The drug is characterized by its linear character when taken. After entering the body, Levolet R solution acts analogously to the tablet form of the drug. Therefore, intravenous or oral administration of the drug can be considered interchangeable.
This medicine quickly penetrates into the tissues of internal organs. A small amount of the drug can be deacetylated or oxidized in the liver. The drug compound is recovered with the help of kidneys.

Indications for use

Such an antibiotic as Levolet R is recommended for use in the following infectious and inflammatory diseases:
    tuberculosis;
    bacterial prostatitis;
    infections of the respiratory tract, genitourinary system and kidneys, including pyelonephritis;
    intra-abdominal infections;
    sinusitis;
    pneumonia;
    infectious diseases of the skin.

Contraindications

The drug is contraindicated in the presence of patients:
    hypersensitivity to quinolones, as well as the components of the drug;
    epilepsy;
    pregnancy;
    age to 18 years;
    defeat of tendons;
    lactation period.
With great care, the drug should be prescribed to the elderly, as well as patients with a deficiency of glucose-6-phosphate dehydrogenase.

Side effects

From the side of the circulatory, digestive, nervous, cardiovascular, genitourinary and musculoskeletal systems, the following side effects may occur during the use of the drug:
    leukopenia;
    anemia;
    nausea;
    dysbiosis;
    stomach ache;
    diarrhea;
    hepatitis;
    loss of appetite;
    tachycardia;
    convulsions;
    collapse of the vascular;
    dizziness;
    drowsiness;
    depressive conditions;
    headache;
    paresthesia;
    trembling in the hands;
    a violation of taste, sight, smell;
    exacerbation of porphyria;
    impairment of kidney function;
    rupture of tendons;
    hypoglycemia;
    muscle pain;
    rhabdomyolysis.
In addition, the use of the drug may provoke allergic reactions in the form of itching, rashes and redness of the skin, anaphylactic shock, fever, phlebitis, epidermal necrolysis, vasculitis, urticaria, Stevens-Johnson syndrome, allergic pneumonitis, and others.

Instructions for use Levolet R (Method and dosage)

It should be noted that the dosage of the drug, as well as the schedule of taking the drug, depends primarily on the patient's condition, the severity of his disease, and the sensitivity of harmful microorganisms to active substances. However, the average duration of treatment will be no more than 14 days.
In accordance with the instruction for the use of Levolet R 500 mg. and 250 mg. Tablets are taken immediately before meals or in breaks between meals, with plenty of water and without chewing. As with other antibiotics, it is advisable to use Levolet R after a minimum of 48 hours from the time of eradication of harmful microorganisms, as well as the normalization of body temperature.
The dosage adjustment is required in cases of treatment of patients with impaired renal function.

Overdose

If the recommendations for dosage are not observed, symptoms such as nausea, confusion, damage to the mucous membranes of the digestive tract, convulsions, prolongation of the QT interval, and dizziness may occur.

Interaction

Reduces the effectiveness of Levolet R antacid medicines, and in addition, preparations containing sucralfate, salts of iron, magnesium and aluminum. Do not use with this drug cimetidine, Theophylline, GCS, NSAIDs and drugs that affect tubular secretion.

Storage conditions

This drug is prohibited from freezing and should be stored in a dry place inaccessible to children, protected from light at a temperature of no higher than 25 ° C.
Shelf life - 2 years.

special instructions

To avoid photosensitivity (damage to the skin) during treatment, you should avoid both natural (sun) and artificial (solarium) ultraviolet radiation. When there is colitis, signs of tendonitis or allergic reactions, you should immediately stop using the drug.
If you have an anamnesis of brain damage, it is worth remembering that in the treatment with Levolet R, patients may experience seizures, in the absence of glucose-6-phosphate dehydrogenase, the risk of hemolysis increases.
When using this medication, whenever possible, it is necessary to avoid activities involving increased concentration of attention, for example, driving a vehicle.

Analogs of Levolet R

The main structural analogues of Levolet R for the active drug compound are:
    Glevo;
    Flexid.

With alcohol

Levolet R, like other antibiotics, loses its distinctive medicinal properties when consuming alcohol during treatment.

Children

The drug is forbidden to use in the treatment of patients under the age of 18 years.

During pregnancy (and lactation)

The medicine is forbidden to take during lactemia and pregnancy.

Reviews about Levolet R

Since the opinions of patients on the effectiveness of the drug were divided, in the free sources you can find quite conflicting reviews on Levon 500 mg., 250 mg. and a solution for diffusion. On the one hand, people talk about a sufficiently budgeted cost of the drug, and on the other - an impressive list of side effects that give rise to doubt the benefits of the drug.