Zinnat tabs 250mg #10

Zinnat instruction for use

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Composition

In the tablets Zinnat 125 mg contains the active component of cefuroxime axetil (125 mg in terms of cefuroxime). Zinnat tablets 250 mg also contain the active component of cefuroxime axetil (250 mg in terms of cefuroxime). In addition, the drug contains additional components: MCC, croscarmellose sodium, sodium lauryl sulfate, colloidal silicon dioxide, vegetable hydrogenated oil.
The granules from which the Zinnat suspension is made contain acetyl as an active substance in the composition of cefuroxime, as well as additional ingredients: stearic acid, sucrose, aspartame, acesulfame potassium, povidone K30, xanthan gum, flavor.

Form of issue

Antibiotic Zinnat is available in the form of tablets and granules, from which a suspension is prepared.
    Tablets with white or almost white film sheath, oval, biconvex. On one side they have engraving "GXES5" (125 mg dose), "GXES7" (250 mg dose). In the section, the tablet is white or almost white in color. Contain in the blister for 5 or 10 pcs. in a cardboard box - 1 or 2 bl.
    Granules are grains that have irregular shapes, different sizes, but not more than 3 mm. The color is white or almost white. After dilution, a white or light yellow suspension is formed which has a fruity aroma. Contains granules in bottles of dark glass, 125 mg / 5 ml. The bottle is closed with a lid made of plastic, equipped with a device against opening the children. A measuring spoon is also inserted in the cardboard pack.

pharmachologic effect

The substance cefuroxime axetil is a precursor of cefuroxime, belonging to the second generation of cephalosporin antibiotics. It shows activity against a wide spectrum of pathogens, including β-lactamase producing strains.
The stability of cefuroxime to the action of bacterial β-lactamases is noted, therefore the substance is effective against ampicillin-resistant or amoxicillin-resistant strains. Has bactericidal effect, which is associated with the process of suppressing the synthesis of the bacterial cell wall due to binding to the main target proteins.
Activity of cefuroxime in vitro in relation to a number of gram-negative aerobes, gram-negative aerobes, anaerobes (cocci Gram-positive and Gram-negative, Gram-positive and Gram-negative rods, Gram-negative spirochetes) was noted.
Insensitive to cefuroxime are such microorganisms: Pseudomonas spp., Clostridium difficile, Acinetobacter calcoaceticus, Campylobacter spp., Strains of Staphylococcus aureus and Staphylococcus epidermidis, which are resistant to methicillin, Legionella spp., Listeria monocytogenes. Also insensitive to the active substance of the drug Zinnat are individual strains of such genera: Morganella morganii, Enterococcus (Streptococcus) faecalis, Serratia spp., Citrobacter spp., Proteus vulgaris, Bacteroides fragilis, Enterobacter spp.

Pharmacokinetics and pharmacodynamics

After the drug has been taken orally, a slow process of absorption of cefuroxime axetil substance from the digestive tract occurs. The substance is rapidly hydrolyzed with the release of cefuroxime in the small intestinal mucosa and in the blood. Penetrates through the placenta, GEB, enters the breast milk. Optimal absorption of the medicine occurs if taken immediately after eating.
The highest concentration of active substance after taking the tablets is observed after about 2.4 hours, provided that the medicine was taken after a meal.
The highest concentration after taking the suspension is observed after about 2-3 hours, provided that the medicine is taken after a meal.
With plasma proteins, communication is approximately 33-50%.
Metabolism in the body cefuroxime is not exposed.
The elimination half-life is 1-1.5 hours. Excreted by tubular secretion and glomerular filtration. Serum concentrations of the substance decrease with dialysis.

Indications for use

Tablets and suspension of Zinnat are indicated for use in order to influence a wide range of Gram-positive and Gram-negative bacteria. It is used for the treatment of infectious-inflammatory diseases, provoked by bacteria that are sensitive to cefuroxime:
    diseases of infectious ENT organs and upper respiratory tract (sinusitis, otitis media, pharyngitis, etc.);
    diseases of the infectious lower respiratory tract (bronchitis, pneumonia, exacerbation of chronic bronchitis);
    diseases of infectious soft tissues and skin (furunculosis, pyoderma, etc.);
    diseases of the urinary tract infection (pyelonephritis, cystitis, urethritis, etc.);
    Lyme disease in its early stages, prevention of late stages of this disease in patients 12 years of age;
    gonorrhea;
    meningitis;
    peritonitis;
    sepsis.

Contraindications

All dosage forms of the drug Zinnat is contraindicated to take with increased sensitivity to β-lactam antibiotics (in the presence of anamnesis sensitivity to cephalosporin antibiotics, carbapenems, penicillins).
Zinnat tablets should not be taken to children under 3 years of age.
Suspension prepared from granules is not prescribed to people who are markedly hypersensitive to aspartame, phenylketonuria. Also, this form of antibiotic should not be used to treat children under 3 months of age.
Caution Zinnat is prescribed for diseases of the digestive system (including history), ulcerative colitis, impaired renal function, and also during pregnancy and breast-feeding.

Side effects

As a rule, negative reactions in the treatment with a drug with active substance cefuroxime axetil are not significant, they are reversible and short-lived. There may be such side effects:
    superinfection with fungi of the genus Candida;
    lymphatic and hematopoietic systems: eosinophilia, thrombocytopenia, false-positive Coombs test, leukopenia, in very rare cases - hemolytic anemia;
    immune system: manifestations of hypersensitivity reactions in the form of rashes on the skin, hives, itching, in very rare cases - serum sickness, drug fever, anaphylaxis;
    nervous system: headaches, dizziness;
    digestive system: disorders of the function of the digestive tract, which are manifested by diarrhea, nausea, pain in the abdomen, sometimes - vomiting, in rare cases - pseudomembranous colitis;
    bile ducts and liver: transient increase in liver enzymes activity, in rare cases - hepatitis, jaundice (mostly cholestatic);
    skin, subcutaneous fat: in very rare cases - erythema multiforme, Stevens-Johnson syndrome.

Instructions for use of Zinnat (Method and dosage)

Antibiotic Zinnat should only be used as directed by a doctor.

Zinnat tablets, instructions for use

As a rule, a medicine in the form of tablets should be taken 7 days, but the duration of the course can be from 5 to 10 days. It is recommended to drink tablets after eating.
Adult patients with most infectious diseases are prescribed 250 mg of Zinnat twice a day. In the treatment of infectious diseases of the urinary tract, 125 mg of 2 p. per day. In infectious diseases of the lower respiratory tract of mild and moderate severity, 250 mg of Zinnat are prescribed 2 times a day, in case of severe diseases, the dose is increased to 500 mg 2 r. per day. In uncomplicated form of gonorrhea, a single dose of 1 g of the agent is indicated.
For the treatment of Lyme disease, 500 mg 2 r. per day, the course of treatment lasts 20 days.
Children with three years in most diseases are prescribed 125 mg of Zinnat 2 r. per day. The greatest daily dose is 250 mg. In the treatment of otitis media or severe infectious diseases, a doctor may prescribe 250 mg 2 r. per day. The permissible dose per day is 500 mg

Suspension Zinnat, instructions for use

A suspension for children is used inside, a reception for children from 3 months is shown.
In most cases, the doctor prescribes a dose of 125 mg 2 r. per day. Children after reaching the age of two years in the treatment of otitis media or serious infectious diseases are receiving 250 mg twice a day, but not more than 500 mg per day.
In the case of prescribing a dose, the dose is calculated based on the child's age and body weight. As a rule, children from 3 months. appoint 10 mg of funds per 1 kg of weight 2 p. per day. In severe infections, the dose can be increased to 15 mg per kg of body weight 2 r. per day, but the child should not take a day more than 500 mg of medication.

Overdose

In the case of an overdose of the drug, increased excitability of the brain can develop up to seizures. In this case, symptomatic therapy is performed taking into account the fact that serum cefuroxime concentrations decrease during peritoneal dialysis and hemodialysis.

Interaction

Bioavailability of cefuroxime may decrease with simultaneous administration of drugs that reduce the acidity of gastric juice. Such drugs level out the effect of increasing the absorption of medication after ingestion.
Zinnat can affect the state of the intestinal microflora, and this leads to a decrease in the reabsorption of estrogens. As a result, the effect of hormonal oral combined contraceptives decreases.
Since a false-negative result is possible due to the ferrocyanide test, it is desirable to use hexokinase or glucose oxidase methods to determine the level of glucose in the blood and in the plasma.
The administration of Zinnat does not affect the quantitative determination of creatinine by the alkaline-picrate method.
With simultaneous application with loop diuretics, tubular secretion, renal clearance, increased concentration of cefuroxime in the plasma, as well as its half-life.
When taken simultaneously with diuretics and aminoglycosides, the likelihood of developing nephrotoxic effects increases.

Storage conditions

Tablets and granules are stored at a temperature of no more than 30 °. The ready suspension should be stored in the refrigerator, the temperature should be 2-8 ° C. It is necessary to protect all forms of Zinnat remedy from children.

Shelf life

You can keep Zinnat tablets for 3 years, pellets - 2 years. Shelf life of the finished suspension is no more than 10 days.

special instructions

Care must be taken when prescribing an antibiotic to people who have an allergic reaction to beta-lactam antibiotics in the anamnesis.
It is important to monitor kidney function during treatment. It should be charmingly done to those patients who receive high doses of medication.
During treatment, patients may have a false positive urine reaction to glucose.
With prolonged use of Zinnat antibiotic, active growth of fungi of the genus Candida is possible. Also, with prolonged treatment, some other resistant microorganisms may grow. In this case, it is advisable to discontinue therapy.
Since pseudomembranous colitis can develop during the treatment with antibiotics of a wide range of influences, it is important to conduct differential diagnosis of pseudomembranous colitis in people who have severe diarrhea during antibiotic treatment or after the course of therapy.
When treating with Zinnat borreliosis, the Yarisch-Gerxheimer reaction can be observed, which is related to the bactericidal activity of the drug with respect to the spirochetes of Borrelia burgdorferi. It is necessary to inform patients about the possibility of developing such symptoms.
If the clinical effect was not observed within 3 days after the start of treatment, the drug should be continued.
You can not crumble or break Zinnat tablets. Therefore, this form of medication is not prescribed for young children, as well as for those patients who have difficulty swallowing.
People with diabetes should take into account that 5 ml of the finished suspension of Zinnat contains 0.25 XE.
Since with the administration of cefuroxime axetil can provoke the development of dizziness, you need to warn patients about the need to carefully drive the vehicle and engage in potentially hazardous activities.

Zinnat for children

Those testimonials about Zinnat for children left by parents testify that this antibiotic for children is used often and successfully. Basically, children are prescribed a suspension, the reception of which effectively facilitates the child's condition. It is important that the instruction for the suspension for children is strictly followed. It should be taken into account that the tablets are not prescribed for children under 3 years, the suspension for children up to 3 months.

In pregnancy and lactation

The use of an antibiotic in pregnancy is possible only if the benefit for a woman exceeds the degree of potential risk to the child. Be wary appoint early in pregnancy. Since the active ingredient enters the breast milk, during the lactation period, the medication can only be taken as prescribed by the doctor and under his supervision.

Reviews of Zinnat

Those parents who gave antibiotics Zinnat for children, reviews write mostly positive. They note that the drug after a few days of administration significantly improved the condition in infectious diseases. However, side effects are rare. As a rule, it is an allergic reaction, a headache. However, most patients, both adults and those users who gave the remedy to children, note that there is a need for taking probiotics after the course of treatment with this medication. Also, the convenience of using the agent in the form of a suspension is mentioned.