Zitrolid caps 250mg #6
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Instruction for ZitrolidYou can buy Zitrolid hereCompositionAntibiotic Zitrolid includes the active substance azithromycin. Additional components: microcrystalline cellulose, magnesium stearate. Capsules consist of gelatin, quinol..
Instruction for Zitrolid
You can buy Zitrolid here
Antibiotic Zitrolid includes the active substance azithromycin. Additional components: microcrystalline cellulose, magnesium stearate. Capsules consist of gelatin, quinoline yellow, ponso 4R, titanium dioxide, azorubin.
Zitrolid Forte contains dihydrate as an active component of azithromycin. Additional substances: microcrystalline cellulose, magnesium stearate. The capsule body consists of titanium dioxide and gelatin. The cap includes a "Sunny Sunset" dye yellow, gelatin, titanium dioxide.
Form of issue
This medicine is an antibacterial agent of systemic action.
Pharmacodynamics and pharmacokinetics
The drug acts as an antibacterial agent. It is active in relation to:
Gram-positive cocci: Streptococcus pneumoniae, St. agalactiae, Staphylococcus aureus, St. pyogenes, group CF and G streptococci, St. viridans;
some anaerobic microorganisms: Clostridium perfringens, Peptostreptococcus spp., Bacteroides bivius;
Gram-negative bacteria: Haemophilus influenzae, Bordetella pertussis, Legionella pneumophila, Campylobacter jejuni, Gardnerella vaginalis, Moraxella catarrhalis, B. parapertussis, H. ducreyi, Neisseria gonorrhoeae;
Mycoplasma pneumoniae, Chlamydia trachomatis, Ureaplasma urealyticum, Borrelia burgdorferi, Treponema pallidum.
Has no effect on gram-positive bacteria, which are resistant to Erythromycin.
The medicine is quickly absorbed from the digestive tract. Bioavailability of the drug - 37%. The maximum concentration is reached after 150 minutes. It penetrates well into the tissues of the urogenital tract, the airways, soft tissues and skin.
The content of active substance in the affected foci is higher than in healthy tissues. Bactericidal concentration persists for 5-7 days after the application of the last dosage.
Excretion from the plasma takes place in two stages: half-life is 14-20 hours in the interval from 8 to 24 hours and 41 hours in the interval from 1 to 3 days. This makes it possible to use the medication once a day.
About half of the dosage is taken out unchanged with bile, and 6% - through the kidneys. Application during meals reduces the maximum concentration of active ingredient by 52%.
Indications for use
Indications for use are infectious diseases, provoked by bacteria that are sensitive to azithromycin.
Do not use this product for hypersensitivity to its components or other antibiotics belonging to the group of macrolides, as well as in case of severe disorders of the liver and kidneys, body weight up to 45 kg, pregnancy and lactation.
Adverse reactions when using the drug may be as follows:
CNS: increased excitement, dizziness, drowsiness, headache, vertigo, paresthesia, excessive fatigue;
gastrointestinal tract: nausea, diarrhea, abdominal pain, jaundice, cholestasis, vomiting, flatulence, increased activity of AST and ALT, as well as bilirubin levels;
allergy: skin rash, hives, itching;
CCC: pain in the chest, palpitations;
genitourinary system: nephritis, vaginal candidiasis;
Other: photosensitization, transient neutrophilia, eosinophilia, with the injection of bronchospasm, inflammation and pain at the injection site.
In rare cases, there is a discoloration of the tongue, tinnitus, constipation, reversible hearing loss (down to deafness), pseudomembranous colitis, liver necrosis, pancreatitis, hepatic insufficiency, Quincke's edema, anaphylactic shock.
In childhood, possible: headache, nervousness, insomnia, hyperkinesia, anxiety, conjunctivitis, decreased appetite, candidomycosis of the oral mucosa, gastritis.
Instructions for the use of Zitrolid (Method and dosage)
When using the drug Zitrolid, the instructions for use recommend swallowing the capsule one hour before meals or 2 hours after it. It is advisable to drink the medicine with water. The daily dosage is usually taken at one time. It is recommended to do this every day at the same time. The duration of therapy and the exact dosages are determined by a specialist and depend on the nature of the disease.
In the case of infectious diseases of the respiratory tract, 500 mg / day is indicated. The course of treatment is 3 days.
In acute uncomplicated diseases of the genitourinary system, 1 g of medicine is indicated once.
In the case of infectious diseases of the skin and soft tissues, and also at the onset of Lyme disease, usually 1 g of Zytrolide is taken on the first day, and then 500 mg for 4 more days.
With peptic ulcers of the stomach and duodenum, which are caused by Helicobacter pylori, one should take, on a daily basis, 1 gram of the drug together with other drugs. The course is designed for 3 days.
Instructions for use Zitrolid Forte reports that the drug is usually taken in the following dosages:
infections of the respiratory tract, skin, soft tissues, ENT organs - 500 mg / day for three days;
acute infections of the urogenital organs - 1 g once;
pneumonia - 500 mg once a day for 7-10 days immediately after the end of the use of IV form;
acne - 500 mg once a day for three days, then in the same dosage, but once a week for 9 weeks. The first weekly dosage is administered 7 days after the first daily dose, followed by an interval of 7 days between doses;
Lyme disease - 1 g in the first day and 500 mg / day for 4 more days.
Children weighing more than 45 kg show the same dosages as adults.
If a mandatory dose of medication is missed, you must take it as soon as the patient remembers it. The next dosage is taken after a day.
In case of an overdose, nausea, vomiting, hearing loss, headaches, dyspepsia are possible.
There is no specific antidote. It is recommended to wash the stomach and take enterosorbents. Treatment is symptomatic.
Do not use Zitrolid in conjunction with ergot alkaloids.
Antacid preparations that include calcium, magnesium or aluminum, as well as ethanol, slow down and reduce the absorption of azithromycin. It takes a two-hour interval between doses.
The toxic effect of dihydroergotamine is enhanced by the influence of Zitrolid. And when combined with warfarin, it is recommended that prothrombin time be monitored.
The drug also increases digoxin levels in the blood, reduces clearance and increases the effect of triazolam.
When interacting with Cycloserin, Methylprednisolone, Felodipine, indirect anticoagulants and drugs undergoing microsomal oxidation, their excretion slows down, toxicity and content in the blood plasma increases. Lincosamides decrease, and tetracycline and chloramphenicol, on the contrary, activate the action of Zitrolid.
The optimum temperature is up to 25 ° C. Keep the product in a dry and dark place.
Three years from the date of the date indicated on the package. Do not use after expiration date.
Analogues of Zitrolid
Analogues of Zitrolid, which have the same composition of active substances and form of release, the following are sold in pharmacies:
All analogues of Zitrolid have their own peculiarities of application. They can not be replaced on their own without consulting a doctor.
Reviews of Zitrolid
Different opinions about Zitrolid can often be found on the Internet. Reviews about it leave those who used this tool for the treatment of gastrointestinal ulcers provoked by Helicobacter pylori, as well as many infectious diseases caused by various bacteria.
As a rule, the remedy is effective. However, doctors' reviews report that it is very important to take it strictly according to the instructions, otherwise the risk of negative side reactions is great. Specialists emphasize the fact that between using the drug and some means, as well as meals, you need to observe a two-hour interval.
Reviews of Zitrolid are often reported on the occurrence of adverse reactions. In particular, the parents write that the children had a worsening appetite, constipation, candidiasis of the oral mucosa, a change in taste, gastritis, conjunctivitis.
Reviews of Zitrolid Forte also basically characterize it as an effective drug. Among the positive moments, a convenient reception scheme is usually noted. But, unfortunately, the side effects of the people taking this remedy arise very often. In addition, many argue about the advisability of buying this drug due to the fact that there are analogues with a lower cost.