All Categories

  • All Categories
  • Allergy
  • Antibiotics
  • Antiseptics
  • Cardiovascular
  • Contraception
  • Dentes and mouth
  • Dermatology
  • Endocrinology
  • Eyes and vision
  • Food supplements
  • Genito-urinary system
  • Havinson's peptides
  • Hemorrhoids
  • Herbal tea
  • Herbs
  • Homoeopathy
  • Hormonal
  • Immune system
  • Joints and bones
  • Medical accessories
  • Medical cosmetology
  • Men's Health
  • Midwifery, gynaecology
  • Miscellaneous
  • Natural oils and tincture
  • Neurology
  • Oncology
  • Otolaryngology
  • Pain relief
  • Poisoning
  • Respiratory system
  • Stomach, bowels, livers
  • Vitamins

Аprovel tabs 150mg #28

  • $33.39
  • 3 or more $32.99
  • Availability:In Stock

Instruction for АprovelReed more and buy Аprovel on this pageCompositionIn 1 tablet irbesartan 150 or 300 mg.Silicon dioxide, lactose monohydrate, magnesium stearate, MCC, sodium croscarmellose, hypromellose, - as auxiliary substa..

Tags: tabs

Instruction for Аprovel

Reed more and buy Аprovel on this page


In 1 tablet irbesartan 150 or 300 mg.
Silicon dioxide, lactose monohydrate, magnesium stearate, MCC, sodium croscarmellose, hypromellose, - as auxiliary substances.

Form of issue

Tablets in a film shell.

pharmachologic effect


Pharmacodynamics and pharmacokinetics


Angiotensin II receptor antagonist. It causes an increase in renin and angiotensin II in the blood and a decrease in the concentration of aldosterone. The concentration of potassium in the blood does not change.
Dose-dependent, lowers blood pressure, but when applied above 900 mg / day, the increase in hypotensive effect is insignificant. Reduction of blood pressure is observed after 3-6 h, the effect persists for 24 hours.
The hypotensive effect increases 1-2 weeks, and the maximum is detected after 1-1.5 months. Effectiveness does not depend on sex. The drug does not affect the level of uric acid in the blood. There is no withdrawal syndrome.
Irbesartan does not affect kidney function in patients with diabetic nephropathy, glomerulonephritis, and therefore is the drug of choice in these patients.


Well absorbed, bioavailability 60-80%. The maximum concentration is determined in the blood after 1.5-2 h, the equilibrium concentration in 3 days. It binds to proteins by 96%.
Metabolized by the cytochrome P450 CYP2C9 system of the liver. It is excreted by the liver and kidneys. T1 / 2 is 11-14 hours. Patients with a violation of the functions of these organs, as well as the elderly, dose adjustment is not carried out.

Indications for use

Aprovel is used for:
    primary hypertension;
    secondary hypertension;
    kidney damage in diabetes mellitus and other diseases.
With caution is prescribed for hyponatremia, stenosis of the aortic valve, stenosis of the renal arteries, ischemic heart disease, severe hepatic and renal failure.


Aprovel is not assigned when:
    hereditary intolerance to galactose;
    age to 18 years.

Side effects

Aprovel can cause:
    dizziness, orthostatic hypotension;
    cough, chest pain;
    nausea, vomiting, diarrhea, heartburn;
    sexual dysfunction;
    increased CK, hyperkalemia;
    pain in the bones and muscles;
    rash, hives, angioedema.

Instructions for use Аprovel (Method and dosage)

The tablet is taken orally, without chewing. Treatment begins with 150 mg once a day, this dose provides control of blood pressure 24 hours. If the dose is ineffective, the dose rises to 300 mg.
In type II diabetes mellitus with arterial hypertension, 150 mg / day is first prescribed with an increase to 300 mg, since this dose is more preferable in the treatment of nephropathy. People over 75 years of age and patients on hemodialysis drug is prescribed in an initial dose of 75 mg. The appointment of a diuretic enhances the effect of the drug.
The drug Ko Aprovel is a combination of Irbesartan + hydrochlorothiazide at dosages of 150 mg / 12.5 mg and 300 mg / 12.5 mg.
Instructions for use Aprovel contains information that the violation of kidney and liver in patients does not require a dose adjustment.


Admission to a dose of up to 900 mg / day. for 2 months was not accompanied by symptoms of an overdose. Possible symptoms: bradycardia or tachycardia, lowering blood pressure.
Treatment consists of washing the stomach, monitoring the patient and performing symptomatic therapy.


Aprovel when used with potassium preparations can cause an increase in potassium in the blood. Thiazide diuretics increase its hypotensive effect.
Preparations containing aliskiren can not be used in conjunction with Aprovel in diabetes mellitus or kidney failure, because there is a high risk of a significant reduction in blood pressure, renal dysfunction and the occurrence of hyperkalemia.
When used with lithium preparations, it is recommended to control lithium in the blood.
NSAIDs weaken the hypotensive effect, increase the level of potassium and the risk of renal dysfunction.
Irbesartan does not affect the pharmacokinetics of digoxin.

Terms of sale

To buy Аprovel online the prescription is not needed.

Storage conditions

At a temperature not exceeding 30 ° C.
Shelf life - 3 years.


Many patients note the effectiveness and convenience in the use of this drug. On the hypotensive effect, this drug is not inferior to the ACE. The hypotensive effect persists for 24 hours, because Aprovel is taken 1 time per day. Patients report a dose-related decrease in blood pressure.
"With Aprovel, I managed to stabilize the pressure after a stroke. I measure pressure 3 times a day »
"This drug started taking after Lysinopril, from which there was a tickle in the throat and a cough"
Side effects are transient and most importantly, there are no undesirable effects, which are characteristic for ACE (in particular, cough). It is noted that the main disadvantage of this drug is a rather high cost.

Write a review

Please login or register to review

Sign Up for Newsletters