Allapinin tabs 25mg #30

Instruction for Allapinin

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Composition

1 tablet of the drug Allapinin includes 25 mg of hydrobromide lappakonitina.
Additional substances: calcium stearate, potato starch, croscarmellose sodium, sucrose.

Form of issue

Biconvex white pills of circular shape.
    10 tablets in a cellular package - 2, 3, 1 or 5 packs in a paper box.
    30 tablets in a cellular box - 1 pack in a paper box.

pharmachologic effect

Antiarrhythmic, sedative, local anesthetic action.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

As Wikipedia points out, lappakonitina hydrobromide refers to antiarrhythmic drugs of class I-C. It blocks the work of fast sodium channels in the membranes of myocardial cells. It inhibits AV conduction and intraventricular conduction, reduces the refractory intervals of the operation of the bundle of the Hisnia, atria, AV-node and Purkinje fibers, does not change the duration of the QT interval, the antegrade speed of the AV node, heart rate, blood pressure and myocardial contraction the initial absence of symptoms of heart failure).
The drug does not inhibit the ability of the sinus node to automatism. Does not cause negative inotropic effect and has no hypotensive effect.
Drug Allapinin has coronary, spasmolytic, local anesthetic, anticholinergic and sedative action. When taken orally, the effect develops after 45-55 minutes, reaches its maximum strength after 75 minutes and lasts about 8 hours.

Pharmacokinetics

Bioavailability is approaching 40%. Is able to penetrate the blood-brain barrier. The elimination half-life is 70 minutes. The drug is evacuated by the kidneys.
With prolonged admission, it is possible to increase the half-life.
With chronic failure of the kidneys, the elimination half-life increases 3-fold, and in hepatic cirrhosis-up to 10 times.

Indications for use

    attacks of flutter and atrial fibrillation;
    ventricular extrasystole;
    supraventricular extrasystole;
    paroxysmal tachycardia of the supraventricular type;
    paroxysmal tachycardia of ventricular type (if there are no organic heart diseases).

Contraindications

    AV-blockade of 2-3 degrees (without the presence of an artificial pacemaker).
    Sinoatrial blockade.
    Simultaneous blockade of the right side of the bundle of the His and one of the branches of the left part.
    Cardiogenic shock.
    Severe forms of arterial hypotension.
    Strong hypertrophy of left ventricular muscular tissue (wall thickness over 1.4 cm).
    Chronic insufficiency of the heart's moderate and severe degree of 3-4 functional class according to the New York classification.
    Severe violations of the liver or kidneys.
    Postinfarction cardiosclerosis.
    Intolerance to fructose, lack of sucrose / isomaltase enzyme, glucose / galactose absorption disorder.
    Age is less than 18 years.
    Allergy to the drug.
Medication with caution is prescribed for disorders of intraventricular conduction, AV blockade of 1 degree, weakness of the sinus node, severe peripheral circulatory diseases, bradycardia, prostatic hypertrophy, electrolyte exchange disorders, angle-closure glaucoma, impairment of conductivity along Purkinje fibers, blockage of one of the bundle bundles. a joint admission with other antiarrhythmic drugs.

Side effects

Side effects of Allapinin:
    From the side of nervous activity, headache, ataxia, dizziness, a feeling of heaviness in the head, diplopia is possible.
    On the part of the circulatory system, there may be disorders of AV conduction and intraventricular conduction, the development of sinus tachycardia, the appearance of arrhythmogenic action, changes in the ECG (increase in the PQ segment, widening of the QRS segment).
    Also, the appearance of skin hyperemia and allergic reactions is not excluded.

Instructions for use on Allapinin (Method and dosage)

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The drug is taken orally after eating, with a small amount of warm water, without chewing.

Allapinin, instructions for use

The drug is prescribed to take 25 mg three times a day (through equal intervals of time). If there is no therapeutic effect, then through Allapinin take four times a day (through equal intervals of time).
It is allowed to increase the dosage to 50 mg to 4 times a day (at equal intervals of time). The maximum daily dose is 300 mg.
The duration of therapy and the question of changing the regimen of admission is decided by the attending physician.

Overdose

Signs of an overdose

The drug has a narrow therapeutic breadth, so it can easily develop severe intoxication (often with the simultaneous administration of other antiarrhythmics), which manifests itself as an extension of the PR and QT segments, an extension of the QRS segment, an increase in the T wave size, as well as possible sinoatrial block, bradycardia, asystole, AV -blockade, attacks of ventricular polymorphic tachycardia, marked decrease in blood pressure, headache, weakening of myocardial contractility, blurred vision, dizziness, digestive disorders a.

Treatment of overdose

Treatment is symptomatic. For the treatment of developed ventricular tachycardia it is forbidden to use antiarrhythmics of I-A and I-C classes. Sodium bicarbonate is able to dampen the widening of the QRS segment, bradycardia and lowering blood pressure.

Interaction

When combined with activators of microsomal enzymes, the effectiveness of lappaconitin hydrobromide decreases and, as a consequence, the risk of toxic effects increases.
Taking antiarrhythmic drugs of other classes increases the likelihood of arrhythmogenic action.
The drug described increases the strength of the action of nondepolarizing muscle relaxants.

Storage conditions

Store in a dark place at a temperature of up to 26 ° C. Keep away from children.
Shelf life - 5 years.

special instructions

In patients, the field of myocardial infarction or with heart failure, as well as in patients with an established pacemaker, may increase the stimulation threshold.
Prior to taking the drug, you need to eliminate electrolyte imbalance, during the treatment period, a regular monitoring of the electrolyte balance is necessary.
With the development of sinus tachycardia during long-term use of the drug, the use of small doses of beta-blockers is allowed.
When there is dizziness, headache, diplopia, it is recommended to reduce the dosage of the drug.
When treating the drug should be careful during the management of vehicles.

Children

The drug is not allowed to appoint persons under 18 years of age.

Allapinin and alcohol

It is forbidden to drink alcohol in the treatment of any antiarrhythmic drugs.

In pregnancy and lactation

The use of Allapinin in pregnancy is not recommended only if there are serious indications and under medical supervision.
It is forbidden to use the drug during lactation.

Reviews

Reviews about Allapinin characterize him only on the positive side. Most patients are confident in the high efficacy and reliability of the drug. There are no reports of adverse events.