Arifam tabs 5mg + 1.5mg #30

Arifam instruction for use

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Active ingredient, group

Amlodipine + Indapamide, an antihypertensive agent combined (BMKK + diuretic)

Dosage Form

film release coated release tablets

Contraindications

- Hypersensitivity to the active substances, other sulfonamides, dihydropyridine derivatives or any of the excipients;
- severe renal failure (creatinine clearance <30 ml / min);
- severe liver failure or hepatic encephalopathy;
- hypokalemia;
- breastfeeding period;
- severe hypotension;
- shock (including cardiogenic shock);
- obstruction of the outflow tract of the left ventricle (for example, a high degree of aortic stenosis);
- heart failure after acute myocardial infarction with unstable hemodynamics;
- galactose intolerance, lactase deficiency or glucose-galactose malabsorption (since ARIFAM tablets contain lactose);
- children under 18 years old.

How to apply: dosage and treatment

Tablets arifam taken orally, 1 tablet 1 time per day, preferably in the morning. The tablet must be swallowed without chewing and drinking water.

pharmachologic effect

Arifam is a combination drug for treating hypertension: the mechanism of antihypertensive action of amlodipine is due to a direct relaxing effect on vascular smooth muscle, while Indapamide increases the excretion of sodium and chlorides in the urine and, to a lesser extent, the excretion of potassium and magnesium, thereby increasing diuresis and exerting an antihypertensive effect .

Side effects of Arifam

Allergic reactions to components Arifam, increased levels of uric acid in blood glucose levels during therapy, anemia, agranulocytosis, aplastic anemia, malaise, asthenia, hyperglycemia, fatigue, hyponatremia with hypovolemia, gynecomastia, mood changes (including anxiety), renal insufficiency , confusion, nocturia, dizziness, back pain, tremor, myalgia, fainting, swelling of the legs, paresthesias, photosensitivity, hypertonus, exfoliative dermatitis, visual impairment (incl. tea diplopia), Stevens-Johnson syndrome, blurred vision, urticaria, tinnitus, exanthema, myocardial infarction, pruritus, pirouette tachycardia (potentially fatal), discoloration of the skin, arterial hypotension, purpura, shortness of breath, may develop hepatic encephalopathy in case of liver failure, cough, increased activity of liver enzymes, nausea, hepatitis, dyspepsia, gingival hyperplasia, dry mouth, pancreatitis, gastritis, changes in bowel function (including diarrhea and constipation), constipation, vomiting, jaundice pain in herpes, liver dysfunction, rhinitis, maculopapular rash, vasculitis, alopecia, flushing of the skin of the face, hyperhidrosis, arrhythmia (including bradycardia, ventricular tachycardia and atrial fibrillation), skin rash, palpitations, angioplasty, strokes, heart rate, angiotrophrosis, strokes, heart failure, angiopathy, heart flow, angiopathy, strokes, heart failure, angioplasty, angiopathy epidermal necrolysis, myopia, erythema multiforme, peripheral neuropathy, angioedema, vertigo, exacerbation of existing acute systemic lupus erythematosus, decreased sensitivity, arthralgia, changes in taste, prolongation of the QT interval by electro cardiogram (ECG), muscle cramps, headache, urinary disturbance, drowsiness, increased urination, depression, impotence, insomnia, edema, hypercalcemia, chest pain, hypokalemia, pain, hemolytic anemia, body weight loss, weight gain.

special instructions

When abnormal liver function, thiazide-like diuretics can cause hepatic encephalopathy, especially in the case of electrolyte imbalance. Due to the presence of indapamide, with the development of this phenomenon, the use of Arifam should be immediately discontinued.

Interaction

Amlodipine

Grapefruit juice can reduce the concentration of amlodipine in the blood plasma, but this decrease is so small that it does not significantly change the effect of amlodipine.
Procainamide, quinidine, and other drugs that prolong the QT interval increase the negative inotropic effect and may increase the risk of significant prolongation of the QT interval.
Inhibitors of microsomal oxidation increase the concentration of amlodipine in the blood plasma, increasing the risk of side effects, and inducers of microsomal liver enzymes reduce.
Non-steroidal anti-inflammatory drugs, especially indomethacin (sodium retention and blockade of prostaglandin synthesis by the kidneys), alpha-adrenostimulants, estrogens (sodium retention), and sympathomimetics weaken the antihypertensive effect.
Thiazide and "loopback" diuretics, beta-blockers, verapamil, ACE inhibitors and nitrates enhance the antianginal and hypotensive effects.
Amiodarone, quinidine, alpha1-blockers, antipsychotic drugs (neuroleptics) and blockers of "slow" calcium channels can enhance the hypotensive effect.
When used together with lithium preparations, it is possible to increase the manifestations of their neurotoxicity (nausea, vomiting, diarrhea, ataxia, tremor, tinnitus).
Calcium preparations can reduce the effect of blockers of “slow” calcium channels.

Indapamide

Increases the concentration of lithium ions in the plasma (reduction of excretion with urine), lithium has a nephrotoxic effect.
Increases the risk of developing renal dysfunction when using iodine-containing contrast drugs in high doses (dehydration). Before using iodine-containing contrast drugs, patients need to restore fluid loss.
Reduces the effect of indirect anticoagulants (coumarin or indanedione derivatives) due to increased concentration of coagulation factors as a result of a decrease in BCC and an increase in their production by the liver (dose adjustment may be required).
Strengthens the blockade of neuromuscular transmission, which develops under the influence of non-depolarizing muscle relaxants.

Storage conditions

Arifam should be stored out of the reach of children at a temperature not higher than 30 ° C.
Shelf life - 2 years.

Pharmacy sales terms

You don't need a prescription to buy Arifam.