Artezine tabs 4mg #30

Artezine user manual

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Composition

The tablets contain the active substance: doxazosin mesylate.
Auxiliary components: potato starch, povidone, lactose monohydrate, magnesium stearate, crospovidone.

Form of issue

Artezine is produced in the form of tablets, packaged in 10 pieces in contour cells and 3 cells in a package.

pharmachologic effect

Tablets Artezine have antihypertensive and vasodilating action.

Pharmacodynamics and pharmacokinetics

The substance of doxazosin is a selective blocker of postsynaptic α1-adrenergic receptors. Taking medication lowers the tone of vascular muscles, decreasing OPSS, helps lower blood pressure.
Single use of tablets has a noticeable hypotensive effect after 2-6 hours, keeping it for at least 24 hours. During treatment, patients with arterial hypertension do not feel differences in pressure values, regardless of the position of the body.
Also, the effectiveness of the drug is noted with hypertension, even if the disease is accompanied by metabolic disorders, for example, obesity, a decrease in glucose tolerance, and so on. The probability of developing coronary artery disease decreases. In the treatment of normotonics, a decrease in blood pressure does not occur. Long-term use of doxazosin does not reduce the antihypertensive effect.
During the treatment of the drug, it is possible to lower the level of triglyceride concentration or total cholesterol in the blood plasma.
Prolonged therapy often causes regression of hypertrophy in the left ventricle, an increase in active plasminogen in tissues, a possible suppression of platelet aggregation.
As a result of blocking α1-adrenergic receptors in the capsule and stroma of the prostate gland, the neck of the bladder, the pressure and resistance in the urethra decrease, the resistance of the internal sphincter decreases. Thus, Artezine in prostatitis helps to improve urodynamics and significantly reduce the symptoms of the disease. The manifestation of a stable effect is observed after 1-2 weeks from the beginning of therapy.
Inside the body, the drug undergoes rapid and good absorption in the digestive tract. At the same time, the absorption of the substance is 80-90%. If food is used concomitantly with the medicine, it is possible to slow the intake by about an hour. The connection with proteins in blood plasma is almost 98%. The substance is excreted from the blood plasma in two stages, therefore it is allowed to apply the medication only once a day.
The drug is metabolized in the liver, resulting in several metabolites. The withdrawal of most of the drug occurs in metabolites through the intestine, a small part in the unchanged form with the help of kidneys.

Indications for use

The use of Artezine is recommended for:
    arterial hypertension in the complex treatment;
    benign prostatic hyperplasia accompanied by hypertension or normal BP.

Contraindications for use

It should be refrained from taking the drug when:
    hypersensitivity to it;
    age to 18 years.
Care should be exercised in cases of violations of the liver, aortic and mitral stenosis, orthostatic hypotension.

Side effects

In the treatment of Artezine, various side effects may occur. Patients suffering from hypertension can develop orthostatic hypotension, general reactions in the form of asthenia, fatigue, malaise, allergic reactions, skin rashes, urticaria. Cardiovascular and nervous system disorders, for example, peripheral edema, syncope, dizziness, headaches, drowsiness are not excluded.
It is also possible the appearance of nausea, rhinitis, bradycardia, tachycardia, palpitations, chest pains, angina pectoris and so on.
During treatment of patients with DCP, the same side effects as those observed in people with arterial hypertension may appear. In addition, other undesirable actions may develop: allergic reactions, disruption of endocrine, digestive, urinary, respiratory and hematopoiesis.

Artezine, instructions for use (Method and dosage)

Tablets are intended for ingestion once a day, wholly, with water.
Begin the treatment of arterial hypertension with a daily dosage of 1 mg, recommended for taking before bedtime. Having taken the first dose of the drug, the patient needs to be in bed about 6-8 hours, as the phenomenon of the first dose may develop.
If after 1-2 weeks the therapeutic effect was insufficient, it is possible to increase the daily dose to 2 mg. The next increase in dosage by 2 mg is allowed only after 1-2 weeks and so on. As clinical practice shows, the achievement of the optimal therapeutic effect occurs when taking a daily dose of 8 mg. The maximum possible daily dosing is 16 mg.
When a persistent therapeutic effect is achieved, a reduction to a maintenance dosage of 2-4 mg is possible.
Treatment with BPH starts with a daily dosage of 1 mg, which minimizes the risk of developing orthostatic hypotension, as well as fainting. Given the indices of urodynamics and symptomatology of BPH, it is possible to increase the dosage, but not earlier than 1-2 weeks later.
The average maintenance daily dose is 2-4 mg, the maximum allowable - up to 8 mg.
Possible long-term treatment, the duration of which sets the attending physician.

Overdose

In cases of overdose, there is a pronounced decrease in blood pressure, an unconscious condition.
In this case, treatment is carried out depending on the symptomatology that has been manifested, having previously laid the patient in bed.

Interaction

Combination with antihypertensive drugs can enhance their hypotensive effect.
In combination with inducers of microsomal oxidation, the effectiveness of Doxazosin increases, and with inhibitors, NSAIDs, for example, Indometacin, estrogens and sympathomimetic agents, on the contrary, decreases.
Simultaneous reception with cimetidine may increase the bioavailability of the drug.

special instructions

This drug should be administered with extreme caution to patients with impaired liver function, especially when taking drugs simultaneously with a hepatotoxic effect. If the performance of the liver deteriorates, then the treatment is immediately canceled. To prevent orthostatic reactions, patients should avoid sudden and abrupt changes in the position of the body.
Prior diuretic therapy or a diet with limited sodium intake may cause a first-effect effect. Also, before the start of treatment should be excluded the presence of cancer degeneration of the prostate gland.
It was found that Artezine causes orthostatic reactions, at the initial stage of therapy or with increasing doses. Therefore, patients should refrain from any hazardous activities, for example, driving, other machinery and vehicles.

Terms of sale

To buy Artezine online the prescription is not required.

Storage conditions

Tablets are stored in a cool, dry place, inaccessible to children.
Shelf life - 3 years.

Alcohol

Taking alcohol can increase the manifestation of unwanted reactions.

Reviews of Artezine

As the reviews on Artezine show, this drug can significantly improve the patient's condition, although everyone knows that it is impossible to completely eliminate arterial hypertension.
When the drug is prescribed in the complex treatment of hypertension, many patients note the normalization of blood pressure and improvement in overall well-being. It is known that such a violation requires long-term therapy, which in most cases is very effective.
Quite often there are stories of patients when Artezine is prescribed for prostatitis. Taking this medicine, for some time, men report that they feel better, but some time after the end of treatment, unwanted symptoms return.
According to experts, this drug has good efficacy and can improve health, both in the treatment of hypertension, and benign prostatic hyperplasia. Of course, each of these violations requires a special approach to treatment, increased attention and caution. At the same time, only the doctor can prescribe the treatment, according to the results of diagnostic studies.