Calchek tabs 5mg #30

Tablets Calchek user manual

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Composition

Amlodipine, corn starch, calcium hydrogenphosphate, talc, colloidal silicon dioxide, sodium carboxymethyl starch, magnesium stearate.

Form of issue

Tablets are flat round in white form in a dosage of 2.5; 5 and 10 mg of amlodipine in a blister pack in cardboard pack No. 20, 30.

pharmachologic effect

Antianginal, antihypertensive, antispasmodic, vasodilating.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Refers to preparations derived dihydropyridine, has antianginal, vasodilating and hypotensive effect. The mechanism of action is based on the blockade of calcium channels, which inhibits the process of transmembrane transfer of calcium into the cell (mainly in the smooth muscle cells of the vessels, to a lesser extent in the cardiomyocytes).
Antianginal effect is due to the expansion of the coronary arteries and peripheral arterioles, which in angina conditions reduces the severity of cardiac muscle ischemia and OPSS, myocardial oxygen demand, reduces preload on the heart muscle.
The drug has a dose-dependent antihypertensive effect, which is caused by a vasodilating effect on smooth muscle vessels. In this case, a sharp decrease in blood pressure does not cause. With IHD has antiatherosclerotic and cardioprotective action, reduces myocardial hypertrophy. The effect comes in 2-4 hours and lasts about a day.

Pharmacokinetics

The active substance Calchek quickly and almost completely absorbed from the digestive tract. Bioavailability of the drug is about 65%. Cmax is achieved in 10 hours. The connection with the blood proteins is high. Isolated with breast milk, penetrates through the BBB. The process of biotransformation occurs in the liver, while the metabolites formed do not have pharmacological activity. It is excreted through the kidneys and intestines.

Indications for use

Treatment of arterial hypertension, stable / unstable angina, Prinzmetal angina (angiospastic angina pectoris).

Contraindications

High sensitivity to the drug, severe arterial hypotension, lactation, Take with caution the patient with hepatic insufficiency, aortic stenosis, after a heart attack, CHF, under the age of 18 and in old age.

Side effects

Excessive fatigue, dizziness, headache, drowsiness, mood swings, convulsions, nausea, jaundice, abdominal pain, dry mouth, vomiting, stool disorders, palpitation, shortness of breath, swelling, local allergic reactions.

Calchek, instructions for use (Method and dosage)

Kalkchek tablets taken internally. Dosage: the initial dose is 5 mg / day once with a gradual increase in the dose for 10 days to 10 mg / day. The maintenance dose for arterial hypertension varies between 2.5 and 5 mg / day.
Persons with a dysfunction of the liver and the elderly as an antihypertensive drug are prescribed in a dose of 2.5 mg; with angina pectoris take only once for 5-10 mg / day; with the purpose of preventing attacks of angina pectoris take 10 mg / day.

Overdose

Tachycardia, a sharp decrease in blood pressure, in severe cases - with the development of shock.

Interaction

When combined with NSAIDs, estrogens, alpha-adrenostimulators, sympathomimetics, the hypotensive effect of the drug is weakened. Diuretics, ACE inhibitors, beta-blockers, and nitrates increase the hypotensive and antianginal effect. With a joint admission with neuroleptics, quinidine, alpha1-adrenoblockers, the risk of intensifying the hypotensive effect increases. With simultaneous use with Li + drugs, the risk of increasing neurotoxicity increases.

Terms of sale

You don't need a prescription to buy Calchek online.

Storage conditions

At a temperature of 10-25 ° C.
Shelf life - 24 months.

Reviews about Calchek

Reviews about the drug in most patients are positive. Its effectiveness and low cost are noted.
"... I suffer from hypertension for many years. I tried many medicines and folk remedies. On the recommendation of a doctor, I take Calchek one tablet a day. While the drug is satisfied, the pressure is normal. "