Co-Renitec tabs 20mg/12.5mg #28

Co-Renitec instruction

You can buy Co-Renitec online

See also - Renitec

Composition

Co-Renitec contains active ingredients such as enalapril maleate and hydrochlorothiazide. In addition, it has such additional components as iron oxide, yellow oxide, corn pregelatinized starch, corn starch, water lactose, sodium bicarbonate, magnesium stearate.

Form of issue

The medicine is produced in tablets, which are in the blisters contained in the package.

pharmachologic effect

The drug is an ACE inhibitor and a diuretic.

Pharmacodynamics and pharmacokinetics

This drug reduces the level of sodium ions in the vessel wall, blood pressure, arterial vascular tone, OPSS, and also increases diuresis. The hypotensive effect lasts for 24 hours.
Thus, the drug is effective in the case of hypertension. The hypotensive effect of the active ingredients of the drug complements each other. Therapy with this drug is more effective in most cases with arterial hypertension than the use of enalapril maleate and hydrochlorothiazide alone.
Enalapril is an ACE inhibitor. After absorption, it is metabolized to enalaprilate. Its effect leads to a decrease in the level of angiotensin II in the plasma, which increases the activity of renin of the blood plasma and decreases the secretion of aldosterone. In addition, enalapril prevents the destruction of bradykinin.
Reduction of blood pressure is accompanied by a decrease in the total peripheral resistance of blood vessels and a slight increase in cardiac output. The drug increases renal blood flow. This does not change the rate of glomerular filtration, unless in patients it was not initially reduced.
Hydrochlorothiazide is a diuretic and antihypertensive agent that promotes increased renin activity. Thus, in combination with enalapril, it leads to a more significant decrease in blood pressure. The withdrawal of the drug does not cause a sharp increase.
The maximum effect, as a rule, appears after 2-4 hours after application. The hypotensive effect is noticeable in an hour. The duration of the drug depends largely on the dosage. As a rule, it lasts throughout the day.

Indications for use

This remedy is indicated for arterial hypertension, if the combination therapy is considered to be the most effective.

Contraindications

Do not use Co-Renitec with hypersensitivity to its components, childhood, anuria, Quincke's edema, as well as hereditary or idiopathic Quinck's edema.
Caution this tool is assigned when:
    bilateral stenosis of the renal arteries;
    ischemic heart disease;
    aortic stenosis;
    severe systemic connective tissue diseases;
    diabetes mellitus;
    condition after kidney transplantation;
    dietary nutrition with limited sodium content;
    old age;
    cerebrovascular diseases;
    chronic heart failure;
    renal failure;
    oppression of bone marrow hematopoiesis;
    The conditions accompanied by a decrease in the volume of circulating blood;
    hepatic insufficiency;
    hyperkalemia;
    stenosis of the artery of a single kidney.

Side effects

Negative adverse reactions, according to studies, tend to be of a moderate nature. Usually they do not need to cancel therapy. Side effects can be as follows:
    respiratory system - the appearance of dyspnea, cough;
    CCC - palpitations, orthostatic effects, fainting, arterial hypotension, chest pain, tachycardia;
    musculoskeletal system - the appearance of muscle cramps, pain in the joints;
    kidneys - development of renal failure, problems with kidney function;
    laboratory indicators - hyperglycemia, hyperkalemia, hypokalemia, hyperuricemia, decrease in hematocrit and hemoglobin;
    CNS - dizziness, increased excitability, asthenia, paresthesia, fatigue, drowsiness, headache, sleep disturbances;
    digestive system - dyspepsia, diarrhea, nausea, flatulence, dry mouth, vomiting, abdominal pain, constipation, pancreatitis;
    allergy - itching, rash;
    sexual system - the development of impotence, decreased libido;
    others - a noise in the ears, gout.
In rare cases, when taking medication, such unwanted manifestations as angionevrotic edema of the glottis, limbs, tongue, face, larynx, lips, Stevens-Johnson syndrome, intestinal Quincke edema, hyperhidrosis are possible.

Instructions for use Co-Renitec (Method and dosage)

This drug is applied orally on the pill once a day. If necessary, the dosage can be increased to two tablets per day.
Instructions for use Co-Renitec recommends monitoring the water-electrolyte balance data. If the patient previously took diuretics, you should wait 2-3 days before using Co-Renitek tablets. In cases where there is an increase in urea and creatinine in the blood, the use of the drug should be discontinued.

Overdose

When enalapril is taken in elevated doses, it is possible to significantly lower blood pressure (about 6 hours after ingestion) and stupor. An overdose of hydrochlorothiazide can lead to an imbalance of electrolytes and dehydration due to excessive diuresis.

Interaction

Co-Renitec can be used with other antihypertensive drugs. Then the summation of the action is observed. In combination with potassium supplements, potassium-containing salts and potassium-sparing diuretics, hyperkalemia is likely.
When interacting with lithium preparations, lithium removal through the kidneys is reduced. Increased likelihood of lithium intoxication.
NSAIDs reduce the effect of the drug. And if they are taken by patients with kidney problems, this combination can lead to a worsening of kidney function. But these changes are reversible.
The hypotensive effect of the drug reduces estrogens and ethanol. Immunosuppressants, cytostatics and Allopurinol increase the probability of hematotoxicity.

Terms of sale

You can buy Co-Renitec without a prescription.

Storage conditions

Temperature - up to 30 ° C. Keep the drug in a dry place.
Shelf life - three years.

Reviews on Co Renitec

Reviews on Co-Renitec indicate its effectiveness. On adverse reactions reported rarely. Patients usually say that side effects go by themselves and do not require the withdrawal of treatment.