Cordinic tabs 10mg #60

Cordinic instruction for use

You can buy Cordinic here

Cordinic - antianginal agent - potassium channel activator. The action of the drug due to its constituent active ingredient - Nicorandil.
Nicorandil has antianginal action, which is based on a combination of nitrate-like properties and the ability to open potassium channels. Due to the opening of potassium channels, nicorandil causes hyperpolarization of the cell membrane, and nitrate-like
the effect is to increase the intracellular content of cyclic guanyl monophosphate. These pharmacological effects lead to the relaxation of smooth muscle cells and the cellular defense of the myocardium during ischemia. Hemodynamic effects are expressed in a balanced decrease in pre- and afterload (as opposed to nitrates and “slow” calcium channel blockers (BCCA), which act mainly on pre- or afterload, respectively). Taking into account the selective vasodilation of the coronary arteries, as a result, the load on the ischemic myocardium is minimal. Nicorandil does not affect myocardial contractility, practically does not change the heart rate (HR). Reduces systemic blood pressure (BP) by less than 10%, has a beneficial positive effect on cerebral circulation in patients with ischemic stroke. Nicorandil does not affect lipid metabolism and glucose metabolism. Nicorandil relieves an attack of angina with a decrease in pain within 4-7 minutes after taking under the tongue and its complete relief for 12-17 minutes.
Pharmacokinetics. Nicorandil is rapidly and completely absorbed from the gastrointestinal tract, reaching the maximum plasma concentration in 0.5-1 hour. It is not subject to intensive metabolism in the liver and has a half-life of 50 minutes. Excreted mainly by the kidneys.
Nicorandil slightly associated with plasma proteins. The free fraction in plasma is about 75%.
Pharmacokinetic indicators depend little on the age of the patient, the presence of concomitant pathology of the liver or kidneys, the appointment of concomitant therapy.

Indications for use

The drug Cordinic used to relieve strokes; prevention of attacks of stable angina pectoris (in combination with other antianginal agents) and in monotherapy with intolerance to beta-blockers and BMCC.

Mode of application

Tablets Cordinic taken orally. Squeezed with water, take, regardless of the meal.
The dose of the drug is selected individually depending on the severity and duration of the disease.
Relief of an angina attack.
The drug should be taken immediately at the first signs of an angina attack: the drug at a dose of 20 mg is placed under the tongue and held until completely dissolved, without swallowing.
Prevention of attacks of stable angina (long-term therapy of stable angina).
The drug is usually prescribed in a dose of 10 to 20 mg 3 times a day.
The maximum daily dose of 80 mg.
If a headache occurs, the initial dose may be reduced.

Side effects of Cordinic

Cardiovascular system: heartbeat, tachycardia, lowering blood pressure, blood flushes to the skin of the face, peripheral edema.
Central nervous system: weakness, headache (does not require discontinuation of the drug, can be alleviated by reducing the initial dose of the drug), dizziness, tinnitus, insomnia.
Digestive tract: nausea, vomiting, discomfort in the stomach, feeling of fullness in the stomach, stomatitis (extremely rare); in some cases, it is possible to increase the activity of “hepatic” transaminases (alanine aminotransferase and aspartate aminotransferase), alkaline phosphatase.
Hypersensitivity reactions: allergic reactions may develop.

Contraindications

Contraindications to the use of Cordinic tablets are: hypersensitivity to the drug; acute myocardial infarction (and for 3 months after); cardiogenic shock, collapse; unstable angina; chronic heart failure of the III or IV functional class according to the NYHA classification; severe bradycardia (heart rate less than 50 beats / min); atrioventricular block II and III; left ventricular failure with low filling pressure; arterial hypotension (systolic blood pressure less than 100 mmHg); simultaneous administration of phosphodiesterase-5 inhibitors (sildenafil, vardenafil, tadalafil); pregnancy and lactation; age up to 18 years (efficacy and safety have not been established).
With care: cardiac arrhythmias, atrioventricular block I degree, Prinzmetal angina, hypotension, renal and / or liver dysfunction, hypovolemia, pulmonary edema, angle-closure glaucoma, hyperkalemia, anemia.

Pregnancy

Take Cordinic tablets during pregnancy is contraindicated.

Interaction with other drugs

While taking Cordinic with antidepressants, phosphodiesterase-5 inhibitors (sildenafil, vardenafil, tadalafil), vasodilators, antihypertensive drugs, tricyclic antidepressants, diuretics, monoamine oxidase, monoamine oxidase, monoamine oxidase, monoamine oxidase, anti-depressants, diuretics, monoamine oxidase, anti-depressants, monoamine oxidase, anti-depressants, diuretics, anti-depressants, monoamine oxidase, anti-depressants, diuretics, anti-depressants, monoamine oxidase, anti-depressants, diuretics, anti-depressants, anti-depressants, monoamine oxidase, anti-depressants, diuretics, anti-depressants, monoamine oxidase, anti-depressants
At the same time taking the drug with the drug sapropterin may decrease blood pressure below normal.

Overdose

Symptoms of an overdose of the drug Cordinic: pronounced decrease in blood pressure, tachycardia.
Treatment: gastric lavage, the appointment of activated carbon (especially in the first 2 hours after an overdose), maintaining function
cardiovascular system, the elevated position of the limbs, symptomatic and supportive therapy, in / in the introduction of calcium gluconate and dopamine. Perhaps the use of hemodialysis.

Storage conditions

The preparation Cordinic should be stored in a dry, dark place at a temperature not higher than 25 ° C. Keep out of the reach of children.

Release form

Cordinic - tablets 10 mg and 20 mg.
10 tablets in a blister pack.
2, 3 or 6 blister packs together with instructions for use are placed in a pack of cardboard.

Composition

The composition for the dosage of 10 mg: active substance: nicorandil 10 mg; excipients: potato starch - 5 mg, microcrystalline cellulose 102 - 84 mg, calcium stearate - 1 mg;
Composition for dosage of 20 mg: active substance: nicorandil 20 mg; excipients: potato starch - 10 mg, microcrystalline cellulose 102 - 168 mg, calcium stearate - 2 mg.

Additionally

Drug needs to be canceled gradually.
During the period of drug therapy, it is necessary to monitor blood pressure, ECG indicators, the content of potassium ions and sodium ions in the blood; may increase existing cardiac arrhythmias.
Care must be taken when driving and engaging in other potentially hazardous activities that require increased concentration and psychomotor speed.

Terms of sell

You can buy Cordinic without a prescription.