Doxazosin tabs 4mg #30

Doxazosin user manual

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Composition

One tablet contains an active component of doxazosin mesylate.
Additional ingredients: milk sugar, starch, sodium glycolate, magnesium stearic acid, sodium lauryl sulfate and MCC.

Form of issue

Doxazosin is produced in the form of tablets in 10 or 25 pieces in a cellular package, 1-5 packs per pack or 30, 50, 100 pieces in a can or vial.

pharmachologic effect

The drug shows lipid-lowering, hypotensive, antispasmodic and vasodilating effect.

Pharmacodynamics and pharmacokinetics

Doxazosin is characterized by selective blocking of postsynaptic alpha 1-adrenergic receptors. Admission of this drug reduces the tone of vascular muscles, lowers blood pressure, reduces the concentration of triglycerides and total cholesterol in the plasma.
There is also a suppression of platelet aggregation and an increase in the content of active plasminogen in tissues. The tonus in the smooth muscle cells of the stroma, the capsules of the prostate gland, the neck of the bladder decreases. Resistance decreases, and pressure in the area of ​​the urethra, the resistance of the internal sphincter decreases.
A single dose of the drug allows you to achieve an antihypertensive effect after 2-6 hours, which lasts no less than 24 hours. Long-term therapy can cause regression of left ventricular hypertrophy.
The medicine is well absorbed, absorbing almost 80-90%. Simultaneous eating can slow this process. Achieving maximum concentration is noted after 3h, if the drug is taken in the evening, then after 5h. With regard to bioavailability, it is 60-70%, the connection with plasma proteins is almost 98%. Metabolism occurs mainly in the liver. The substance is released in the form of metabolites through the intestine and kidneys.

Indications for use

Doxazosin is prescribed for:
    arterial hypertension in mono- or combined treatment;
    benign prostatic hyperplasia.

Contraindications for use

Do not prescribe this drug with:
    hypersensitivity;
    lactation, pregnancy;
    age to 18 years.

Side effects

Doxazosin, primarily at the beginning of therapy, can cause orthostatic hypotension, sometimes leading to a fainting condition. To prevent the development of orthostatic hypotension, patients do not need to suddenly and dramatically change the position of the body.
Also possible: headache, weakness, dizziness, increased fatigue, drowsiness, rhinitis and nausea. With arterial hypertension can additionally develop: tachycardia, arrhythmia, chest pain, myocardial infarction, angina attacks and cerebrovascular disorders.
In rare cases, allergic reactions and general abnormalities are noted: skin rashes, jaundice, dry mouth, constipation, nosebleeds, urinary incontinence, increased appetite, and so on.

Instructions for Doxazosin (Method and Dosage)

As the instruction on the use of Doxazosin informs, the taking of tablets does not depend on the consumption of food. The medication is taken internally as a whole, with water.
In the treatment of arterial hypertension, various dosing can be established according to the doctor's prescription, depending on the severity of the disease and the characteristics of the patient. Begin therapy with 1 mg, which are taken once a day, preferably at night. Then the patient is recommended to stay in bed for at least 6-8 hours, as the phenomenon of the "first dose" can develop.
If the therapeutic effect is insufficient, then the daily dose is doubled after a 1-2-week treatment, and so on, until the optimal therapeutic effect is achieved. After this, the dose gradually decreases to allow to maintain a normal state.
Treatment of benign prostatic hyperplasia, not accompanied by hypertension, allows the intake of a daily dose of 2-4 mg. The maximum daily dosage should not be above 8 mg.

Overdose

In cases of overdose it is possible to significantly reduce the pressure, accompanied by fainting.
Such patients should immediately take a horizontal position, raise their legs and conduct therapy, depending on the symptomatology.

Interaction

Simultaneous reception with antihypertensive drugs increases their hypotensive effect.
Combination with inducers of microsomal oxidation in the liver can increase their effect, and with inhibitors - reduce. NSAIDs, for example, Indomethacin, as well as estrogens and sympathomimetic drugs reduce the hypotensive effect. The pressor effect of ephedrine decreases, the alpha-adrenostimulating effect of epinephrine disappears, its pressor effect and the development of tachycardia are not ruled out.

Special conditions

Adherence to care requires the treatment of patients with pulmonary edema caused by mitral or aortic stenosis, with a lack of right ventricle of the heart and left ventricle with reduced filling pressure, inadequate cardiac output.
Particular attention should be paid to the therapy of patients with impaired liver function, if they simultaneously take drugs that adversely affect liver function. Deteriorating indicators of the state of liver function requires immediate withdrawal of treatment.
At the initial stage of treatment or when taking the drug in high doses, it is recommended to abandon the performance of hazardous work, transportation management and other mechanisms.

Terms of sale

You can buy Doxazosin without a prescription.

Storage conditions

A dark, dry, cool place, securely protected from children, is suitable for the storage of tablets.
Shelf life - 2 years.

Alcohol

With the simultaneous administration of doxazosin and alcohol, a significant increase in undesirable reactions was noted.

Reviews about doxazosin

In most cases, discussions of this drug are associated with the treatment of benign prostatic hyperplasia. At the same time, many patients report an improvement, but no complete recovery was noted. Therefore, reviews with prostatitis are versatile.
Often, men say that while they take pills and go to physiotherapy, it's getting better. However, after discontinuation of treatment, discomfort is again felt, urination becomes more frequent.
As for the treatment of arterial hypertension, here reviews of Doxazosin are reported that these tablets are usually prescribed in a complex therapy with other drugs. The effectiveness of treatment is also assessed by all patients in different ways.
In any case, treatment with this drug requires a cautious approach. Only the specialist should prescribe the dose and therapeutic regimen, after thorough diagnostic tests. In addition, a periodic examination and a visit to the doctor is required and during treatment.