Lokren tabs 20mg #56

Lokren instruction for use

Reed more and buy Lokren on this page

Composition

One tablet contains the active ingredient betaxolol - 20 mg. Additional substances: sodium amylopectin glycolate, magnesium stearate, MCC, hypromellose, colloidal anhydrous silicon dioxide, macrogol, lactose monohydrate.

Form of issue

The medication is released in tablet form. The aluminum blister contains 14 tablets. In the cardboard bundle there are 2 blisters (28 tablets).

pharmachologic effect

Lokren is a beta-blocker. The mechanism of action of the drug is a blockade of beta1-adrenergic receptors. In addition, Lokren has membrane-stabilizing activity, without having a simpatomimic effect. Pharmacological effects of the drug:
    antianginal;
    hypotensive;
    antiarrhythmic.
The drug can reduce the sensitivity of tissues to catecholamines, reduce heart rate and contractility of the myocardium, inhibit the secretion of renin. Also, the medication prevents an increase in blood pressure under stress and physical exertion.

Pharmacodynamics and pharmacokinetics

After taking the medication quickly, completely absorbed from the digestive tract. The maximum concentration in the blood is reached after two hours (the bioavailability index is about 85%). Poorly passes through the placental and blood-brain barrier, moderately soluble in fats. With blood proteins binds slightly above 50% betaxolol. Metabolized betaxolol in the liver, in the form of metabolites (over 80%) is excreted by the kidneys. The half-life is about 20 hours. When hemodialysis, betaxolol is not removed from the bloodstream. The drug is not addictive.

Indications for use

The agent is prescribed for primary and secondary hypertension; for the prevention of angina pectoris.

Contraindications

    angina of Prinzmetal;
    heart failure;
    severe bradycardia;
    individual hypersensitivity to betaxolol;
    cardiogenic shock;
    combined therapy with sultopride;
    atrioventricular block;
    one-time administration of monoamine oxidase inhibitors;
    cardiomegaly.
The hypotensive agent contains galactose, therefore the drug is contraindicated:
    in the syndrome of malabsorption of galactose / glucose or lactose deficiency;
    congenital galactosemia.
Such diseases and conditions as:
    pheochromocytoma;
    bronchial asthma;
    metabolic acidosis;
    liver failure;
    myasthenia gravis;
    elderly age;
    hemodialysis;
    psoriasis;
    atrioventricular block (I degree);
    thyrotoxicosis;
    depression;
    diabetes;
    CRF
are relative contraindications for the administration of betaxolol.

Side effects

From the nervous system:
    insomnia;
    drowsiness;
    muscle weakness;
    anxiety;
    nightmares;
    confusion of consciousness;
    asthenic syndrome;
    headache;
    hallucinations;
    weakness;
    dizziness;
    increased fatigue.
From the cardiovascular system:
    bradycardia (sinus form);
    orthostatic hypotension;
    decreased blood pressure;
    palpitation;
    AV blockade;
    violation of myocardial functions;
    chest pain;
    manifestation of angiospasm.
From the digestive system:
    change in taste;
    dryness of the oral cavity;
    abdominal pain;
    vomiting;
    constipation;
    nausea;
    diarrhea.
From the respiratory system:
    nasal congestion;
    bronho-and laryngospasm.
With the appointment of large doses, difficulty in breathing is recorded in predisposed patients.
From the endocrine system:
    hyperglycemia;
    hypothyroid condition;
    hypoglycemia.
From the sense organs:
    soreness, dry eyes;
    impaired visual perception.
Allergic responses are possible.
Rarely recorded:
    arthralgia;
    weakening of libido;
    backache;
    erectile disfunction.
As a result of laboratory studies, antinuclear antibodies are sometimes found that can be masked for the symptomatology of lupus erythematosus. In such cases, the withdrawal of Lokren is required.

Instructions for use (Method and dosage)

The medicine is taken orally, with water, without chewing. Observe the reception mode is facilitated by calendar packing with the instructions of the days of the week. The daily dose of the drug is 20 mg. It is recommended to stop treatment gradually, reducing the dose of the medicine in stages to the minimum. Otherwise, the withdrawal syndrome develops.
Instructions for the use of Lokren for patients with renal pathology are somewhat different. Thus, patients with renal insufficiency are prescribed an initial dose of 5 mg / day. With hepatic failure, the daily dose does not require correction. The first 100 hours of therapy with betaxolol require increased attention on the part of doctors.

Overdose

When taking high doses of medicament there are:
    dizziness;
    heart failure;
    bradycardia;
    arrhythmias;
    decreased blood pressure;
    fainting condition;
    cyanosis of the palms, nails;
    difficulty breathing;
    atrioventricular block;
    ventricular extrasystole;
    convulsions.
It is recommended to take enterosorbents and emergency gastric lavage. At registration of a bradycardia or fast falling of a BP appoint or nominate 1 mg of a glucagon. If necessary, additionally, a slow infusion of isoprenaline - 25 μg or dobutamine - 10 μg / kg. If heart failure is detected in a newborn, as a result of taking betaxolol by the mother during pregnancy, immediate hospitalization with long-term administration of isoprenaline and dobutamine in large doses under the supervision of specialists (pediatrician, pediatric cardiologist, resuscitator) is required.

Interaction

With the joint use of Lokren with antiarrhythmic drugs (diltiazem, verapamil, amiodarone, quinidine), the risk of myocardial dysfunction increases dramatically. With the joint use of the drug with floktaphenin, the risk of developing arterial hypotension is increased. In response to the use of halogen-containing anesthetics, Lokren can weaken the compensatory capacity of the heart. NSAIDs, glucocorticoids, antacid, enveloping agents reduce the effectiveness of Lokren.
With the combined use of tricyclic antidepressants, blood pressure drops sharply and orthostatic hypotension is formed. When using Lokren together with dihydropyridine derivatives in patients with heart failure (latent flow), the probability of arterial hypotension increases and cardiac decompensation is formed. Do not recommend taking Lokren along with MAO inhibitors.

Storage conditions

Store at a temperature of 15-25 degrees, in a dark and dry place.

Terms of sale

To buy Lokren online the prescription is not required.
Shelf life - 5 years.

special instructions

Patients with hepatic impairment, as well as patients with impaired renal function (CC is 20 ml / min and above) do not need a correction of the dose of the drug. Clinical observation is recommended on the first day.
When combined with hypoglycemic agents, Lokren is able to mask symptoms of hypoglycemia in patients with diabetes mellitus. The treating doctor should warn patients about the need to control the sugar level. Lokren should be used with caution to people with diabetes mellitus, bronchial obstructive syndrome, atrioventricular blockade (I st.), Heart failure, pheochromocytoma, circulatory disturbance, psoriasis. In the case of a planned operation, Lokren should be canceled 48 hours before the general anesthesia.
The drug is not used in pediatrics. There are no clinical data on the safety, effectiveness of its use in this category of patients.

During pregnancy (and lactation)

The use of a drug during pregnancy is possible, but only in situations where the benefit to the mother exceeds the risk to the fetus. It is recommended to stop lactation for the entire period of treatment, tk. beta-blockers are absorbed into breast milk.

Reviews of Lokren (general view)

Specialized forums for patients contain a lot of information about antihypertensive drugs. Reviews of Lockren on the forums are only positive. In general, the drug is recognized as quite effective. It is believed that the drug is more suitable for patients of middle and young age, because in this category of patients, hypertension is less associated with heart failure.
In addition, the convenience in using the drug is noted, since it has a long-lasting effect. Multiplicity of admission - once a day. Also, most patients have a minimal dose of 5 mg. Lokren is an effective tool that modern cardiologists and therapists have in their arsenal.