Micardis tabs 80mg #28

Micardis instruction

You can buy Micardis here

Composition

One Micardis tablet contains 40 or 80 mg of telmisartan (active substance).
Excipients: sodium hydroxide, polyvidone, meglumine, sorbitol, magnesium stearate.

Form of issue

The medicine is white tablets, oblong, with an engraving "51N" on one edge and a company logo on the other side.
7 such tablets with a dosage of 40 mg in a blister, 2 or 4 such blisters in a cardboard bundle. Either 7 such tablets with a dosage of 80 mg in a blister, 2, 4 or 8 such blisters in a cardboard bundle

pharmachologic effect

Suppression of angiotensin II and, as a consequence, vasodilation. The drug lowers blood pressure, the content of aldosterone in the blood.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Telmisartan is a selective blocker of angiotensin II receptors. Has a high tropism for the AT1 subtype of angiotensin II receptors. Competing with angiotensin II in specific receptors, not having the same effect. Binding has a long character.
Does not have tropism to other receptor subtypes. Reduces the content of aldosterone in the blood, does not inhibit renin in the plasma and ion channels in the cells.
The onset of an antihypertensive effect occurs within the first three hours after taking telmisartan. The action persists for a day or more. The pronounced effect develops a month after a constant intake.
In persons with arterial hypertension telmisartan reduces systolic and diastolic pressure, but does not change the number of heartbeats.
Does not cause withdrawal syndrome.

Pharmacokinetics

When taken orally, it is quickly absorbed from the intestine. Bioavailability approaches 50%. After three hours, the concentration in the plasma becomes maximum. 99.5% of the active substance binds to blood proteins. Metabolized by reacting with glucuronic acid. Metabolites of the drug are inactive. The half-life is more than 20 hours. Output through the digestive tract, excretion in the urine - less than 2%.

Indications for use

    Arterial hypertension.
    Reduction of cardiological morbidity and mortality in persons over 55 years of age at risk.

Contraindications

Micardis tablets are contraindicated in individuals with allergies to drug components, severe liver or kidney disease, intolerance to fructose, pregnancy and lactation, and children under 18 years of age.

Side effects

    From the central nervous system: depression, dizziness, headache, fatigue, anxiety, insomnia, convulsions.
    On the part of the respiratory system: diseases of the upper respiratory tract (sinusitis, pharyngitis, bronchitis), cough.
    On the part of the circulatory system: marked lowering of pressure, tachycardia, bradycardia, chest pain.
    On the part of the digestive system: nausea, diarrhea, dyspepsia, increased concentration of liver enzymes.
    From the musculoskeletal system: myalgia, back pain, arthralgia.
    From the genitourinary system: edema, infection of the genitourinary system, hypercreatininaemia.
    Hypersensitivity reactions: skin rash, angioedema, hives.
    Laboratory indicators: anemia, hyperkalemia.
    Other: erythema, itching, dyspnea.

Micardis, instructions for use

According to the instructions for the use of Micardis, the drug is taken orally. Adults are recommended a dose of 40 mg once a day. In a number of patients, the therapeutic effect is already observed when a dose of 20 mg per day is used. If the pressure drops to the desired level is not observed, the dose can be increased to 80 mg per day.
The maximum effect of the drug is achieved five weeks after the start of therapy.
In patients with severe forms of hypertension, it is possible to use 160 mg of the drug per day.

Overdose

Symptoms: excessive lowering of blood pressure.
Treatment: symptomatic.

Interaction

Telmisartan activates the hypotensive effect of other means of lowering the pressure.
With the joint use of telmisartan and digoxin, a periodic determination of the digoxin concentration in the blood is necessary, since it can be increased.
With the joint administration of lithium drugs and ACE inhibitors, a temporary increase in the lithium content in the blood, manifested by toxic action, can be observed.
Treatment with nonsteroidal anti-inflammatory drugs along with Micardis in dehydrated patients can lead to the development of acute renal failure.

Terms of sale

You don't need a prescription to buy Micardis online.

Storage conditions

Store in a sealed container, at a temperature of up to 30 ° C, in a dry place. Keep away from children.
Shelf life - four years.

special instructions

For dehydrated patients (limiting salt intake, diuretic treatment, diarrhea, vomiting), a reduction in the dose of Micardis is necessary.
With caution appoint persons with stenosis of both renal arteries, stenosis of the mitral valve or aorta, hypertrophic obstructive cardiomyopathy, severe renal, hepatic or heart failure, diseases of the digestive tract.
It is forbidden to use for primary aldosteronism and intolerance to fructose.
With a planned pregnancy, it is necessary to find in advance the replacement of Micardis with another antihypertensive drug.
Use with caution when driving vehicles.
With simultaneous reception with lithium preparations, monitoring of lithium content in blood is shown, since a temporary increase in its level is possible.

Children

The drug is prohibited for use in persons under the age of 18 years.

During pregnancy (and lactation)

It is forbidden to use in pregnant and lactating women.

Reviews of Micardis

Reviews about Micardis are characterized by a low number of reports of side effects, but most patients are dissatisfied with its high price.