Physiotens 0.4mg #28

Physiotens user manual

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Composition

Tablets contain different amounts of active substance - moxonidine - 0.2; 0.3 or 0.4 mg.
In addition, the medicine contains povidone, hypromellose, lactose monohydrate, ethylcellulose, magnesium stearate, talc, titanium dioxide, macrogol 6000, E171, crospovidone, E172. INN: moxonidine.

Form of issue

The preparation is produced in the form of round, convex tablets of different colors in the shell. Tablets with moxonidine 0.2 mg have a gently pink color, 0.3 mg - a soft red, and 0.4 mg - a red matte shade. On each tablet labeling with dosage.
Packages of 14, 28 and 98 pieces (14 in one blister).

pharmachologic effect

A hypotensive agent.

Pharmacodynamics and pharmacokinetics

The active substance directly affects the imidazoline receptors of the central nervous system located in the medulla oblongata. This leads to a decrease in sympathetic n. from. , and blood pressure is reduced.
Due to the fact that imidazole has low similarity in alpha-adrenergic receptors, such common side effects as dryness of mucous membranes and pronounced sedative effect practically do not arise.
All the dependence on food intake, already an hour after the administration, the maximum concentration of the active substance in the blood is observed. About 7% binds to plasma proteins. In the body it is metabolized into guanine derivatives and 4,5-dihydromoxonidine (they are excreted in 5 hours). Moxonidine is excreted per day, mostly by the kidneys.
Pharmacokinetic parameters vary with kidney liver disease and slightly, in the elderly.

Indications for use

Arterial hypertension.

Contraindications

    sensitivity and allergy to components in the formulation;
    heart failure and bradycardia;
    children (up to 18 years);
    liver and kidney disease;
    syndrome of weakness of the sinus node.

Side effects

Possible:
    dryness of mucous membranes;
    bradycardia and weakness;
    a decrease in blood pressure;
    nausea;
    an allergy on the skin.
After the first 14 days of taking the drug, the intensity and frequency of symptoms decreases.

Instructions for use Physiotens (Method and dosage)

According to the instructions for the use of Physiotens tablets taken regardless of food.
The daily dose of the drug is from 0.2 mg to 0.6 mg, taken 2 times. The maximum amount of Physiotens taken at one time is 0.4 mg.
With kidney diseases, a single maximum dose of 0.2 mg, and 0.4 mg per day.

Interaction

It is not recommended to combine with tricyclic antidepressants, other antihypertensives, tranquilizers, ethanol (alcohol), hypnotics and sedatives, benzodiazepine.

Terms of sale

You don't need a prescription to buy Physiotens.

Storage conditions

In a dark, cool place.
Shelf life - 2 years.

special instructions

The effect on the speed of psychomotor reactions has not been fully investigated. It is recommended to refrain from driving motor vehicles and other, requiring a high degree

Reviews about Physiotens

Reviews about Physiotens are good. At long constant reception effectively lowers arterial pressure. Side effects are most often headache and dryness of the oral cavity shell. But after the first weeks of admission they gradually pass. In the reviews on the forums, the accent is made on the fact that the drug can not be abruptly abolished, it is not worth to miss the next appointment. The drug is most often used by older people, take it during crises, and every day after dinner.