Prestarium A 5mg #30

Prestarium A instruction manual

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Prestarium A represents a clinical and pharmacological group of drugs, angiotensin converting enzyme (ACE) inhibitors. They are used to lower blood pressure when it increases.

Composition and form of release

Preterium A is available in the form of a tablet for oral administration. The main active substance of the drug is perindopril, which can have several concentrations in one tablet (dosage):
    2.5 mg - tablets are white, round and biconvex.
    5 mg - tablets of light green color, oblong form.
    10 mg - tablets are green, round and biconvex.
Also in the composition of the tablets Prestarium A includes auxiliary components, which include:
    Hypromellose.
    Maltodextrin.
    Macrogol 6000.
    Magnesium stearate.
    Silicon dioxide is colloidal.
    Titanium dioxide.
    Carboxymethyl starch of sodium.
    Lactose monohydrate.
Pre-history A tablets are packaged in plastic bottles of 30 pieces (for a dosage of 5 mg, a packing of 14 tablets is produced). The bottle is equipped with a special dispenser for extraction of the 1st tablet. In a cardboard bundle, equipped with a control system for the first printing, contains 1 bottle of tablets and instructions for the use of the drug.

Pharmacodynamics and pharmacokinetic

The main active substance of tablets Prestarium A perindopril reduces the level of arterial pressure, it refers to inhibitors of the angiotensin-converting enzyme. This is due to the inhibition (inhibition) of the enzyme, which catalyzes the reaction of the conversion of the biologically active compound angiotensin I to angiotensin II, which causes arterial spasm. Inhibition of the angiotensin-converting enzyme leads to a decrease in the concentration of angiotensin II, relaxation of the walls of arterial blood vessels and a decrease in the level of systemic arterial pressure. Perindopril has a therapeutic effect in the active form of perindoprilat, which is formed in the blood.
After taking the pill Prestarium A inside the active substance of the drug is rapidly absorbed into the systemic bloodstream from the small intestine. It is evenly distributed in all tissues of the body, where it is converted into the active derivative perindoprilat. Further metabolism does not occur and perindoprilat is excreted from the body in an unchanged form by the kidneys. Half-life, during which half of the total concentration of the drug taken is taken out from the body, it is long enough that it makes it possible to take the pill once a day.

Indications for use

The use of tablets Prestarium A is shown in several pathological conditions of the body, accompanied by an increase in the level of systemic arterial pressure, these include:
    Isolated arterial hypertension.
    Prevention of the development of a repeated stroke of the brain against a background of increased blood pressure.
    Prevention of cardiovascular complications associated with intravascular thrombus formation.
Also, the drug is used for chronic heart failure to reduce the functional load on the heart by lowering blood pressure.

Contraindications

There are several pathological and physiological conditions of the body that are contraindications to the use of tablets Prestarium A, they include:
    Angioneurotic edema (pronounced edema of the body tissues associated with increased vascular wall permeability against the background of the development of an allergic reaction), which took place in the past and was associated with the use of drugs of the ACE inhibitors group.
    Hereditary or idiopathic angioedema.
    Simultaneous use of aliskiren or aliskiren-containing drugs in patients with concomitant diabetes mellitus or renal insufficiency.
    Lactase deficiency, lactose intolerance, glucose-galactose malabsorption and other pathological conditions, in which the digestion or absorption of lactose carbohydrate, which is an auxiliary component of Prestarium A tablets, is disrupted.
    Pregnancy and lactation.
    Individual intolerance of the active ingredient or auxiliary components of the drug.
    Children under 18 years of age, which is due to the fact that the safety of the drug at this age is not exactly established.
    Hypersensitivity to other drugs of the pharmacological group of ACE inhibitors.
With caution, Prestarium A tablets are used for bilateral stenosis (narrowing) of the renal arteries, the presence of only one functioning kidney, the system pathology of connective tissue (rheumatism, scleroderma, systemic lupus erythematosus), a decrease in the volume of circulating blood (including caused by severe diarrhea, use of diuretics), simultaneous use of drugs that inhibit the activity of the immune system (immunosuppressors), diabetes mellitus, thyroid pathology, decompensated serous echnoy failure, the simultaneous use of potassium-sparing diuretics, potassium drugs during surgery, hemodialysis, hyposensitizing therapy, the state after undergoing kidney transplantation, obstructive hypertrophic myocardiopathy. Before prescribing Prestarium A tablets, the doctor must be sure that there are no contraindications.

Dosage and route of administration

Pre-history A tablets are taken orally, 1 tablet once a day, usually in the morning before breakfast. Dosage and mode of application of the drug is selected individually and depends on medical indications:
    Arterial hypertension - the drug can be used alone or in combination with other medicines. The initial dosage is 5 mg once a day, then, if necessary, it can be increased to 10 mg per day (the maximum allowable dose). To some groups of patients (the presence of a concomitant decrease in the volume of circulating plasma, the concentration of the basic mineral salts in the plasma, chronic heart failure, age over 75), the initial dose may drop to 2.5 mg per day.
    Combined therapy of heart failure with concomitant increase in the level of systemic blood pressure - the initial dose of the drug is 2.5 mg per day, while careful monitoring of the doctor is required. If necessary, the dose rises to 5 mg per day.
    Prevention of repeated development of cerebral stroke - the drug is usually used in combination with indapamide (antihypertensive drug of the second line), the initial dose is 2.5 mg, then after 2 weeks it is increased to 5 mg per day, and at the time of inclusion in therapy, indapamide is again reduced .
Duration of the use of tablets Pre-history A is determined by the doctor individually. In a significant number of cases, a life-long medication is required.

Side effects

Against the background of taking Prestarium A tablets, it is possible to develop negative reactions of the body from various organs and systems that have similarities, characteristic for the use of all preparations of the pharmacological group, ACE inhibitors:
    The digestive system - nausea, vomiting, constipation, periodic abdominal pain, changes in taste, less often the dryness of the mucous membrane of the mouth, less often - inflammation of the pancreas (pancreatitis) or liver (hepatitis).
    Nervous system - a violation of the sensitivity of the skin (paresthesia), dizziness, headache, somewhat less often there are sleep disorders, rapid mood swings, fainting and confusion.
    Cardiovascular system - marked reduction in blood pressure (arterial hypotension), less often - vasculitis (inflammation of blood vessels), tachycardia (acceleration of cardiac contractions). Due to a sharp decrease in blood pressure, it is possible to develop a myocardial infarction, stroke of the brain.
    The system of breathing is dry cough, shortness of breath of varying severity, bronchospasm may be narrowed less often, eosinophilic pneumonia (specific inflammation of the lungs) and rhinitis (inflammation of the nasal mucosa) are even less common.
    Urinary tract - rarely kidney failure may develop.
    Sexual system - violation of erection and ejaculation in men.
    Musculoskeletal system - uncontrolled spasms of the muscles, less often - pain in the muscles (myalgia) and joints (arthralgia).
    Skin and subcutaneous tissue - rash, itching of the skin, urticaria (rash, itching and puffiness, reminiscent of nettle burn and having an allergic origin), angioedema, subcutaneous tissue localized mainly in the face, increased sweating, photosensitivity (significant sensitivity to light) of the skin.
    Organs of the senses - reduced visual acuity, tinnitus.
    System of blood - rarely increases the number of eosinophils (eosinophilia), which are cells of the immune system, responsible for the development of allergic reactions.
Also, against the background of taking Prestarium A tablets, the patient's general condition may be disturbed, which is characterized by weakness, decreased ability to work. In case of side effects, the doctor decides whether to cancel the drug or reduce its dosage individually.

special instructions

With regard to the use of Pre-Stary A tablets, there are a number of special instructions that the doctor must take into account before their appointment:
    During the prescription of the drug to patients with coronary heart disease in the first month of the use of Prestarium A tablets, episodes of unstable angina may develop. In this case, the doctor assesses the appropriateness of further use of the drug.
    Reduction of the volume of circulating blood, regardless of its cause, can lead to a sharp drop in blood pressure after the start of taking Prestarium A.
    Reduction of blood pressure is usually accompanied by dizziness, weakness, darkening in the eyes. If this condition develops after taking the drug, the patient should take a horizontal position of the body on the back with raised legs, which will ensure the best blood supply to the brain.
    The drug is administered with caution to patients with concomitant stenosis (constriction) of the initial aorta.
    Patients with concomitant decrease in the functional activity of the kidneys of moderate severity, the drug is used with caution, as possible deterioration of their functional state.
    In rare cases, against the background of the use of tablets Prestarium A, cholestatic jaundice developed.
    In representatives of the Negroid race, the risk of angioedema development after the start of taking Prestarium A tablets is much higher.
    Against the background of the use of the drug can develop a persistent dry cough, which disappears after cancellation.
    After starting taking Prestarium A tablets, patients with concomitant diabetes should be monitored periodically for blood glucose, since a dose adjustment of hypoglycemic drugs may be required.
    The active ingredient perindopril can interact with a significant number of drugs from other pharmacological groups, so if this is the case, the treating doctor should be warned.
    The drug is not used for children, pregnant and breast-feeding women.
    Performing potentially dangerous work during the use of the drug is undesirable, since it is possible to develop side effects from the central nervous system.
Prestarium A tablets are released in the pharmacy network only with the prescription of a doctor. Their independent use is not recommended, as it can lead to the development of complications.

Overdose

There are no reliable data on the overdose of Prestarium A tablets to date. Perhaps a sharp decrease in blood pressure, as well as the development of adverse adverse reactions from various organs and systems. In this case, the drug is stopped and symptomatic therapy is performed in a medical hospital.

Terms and conditions of storage

The shelf life of PreStarium A tablets is 3 years from the date of their manufacture. There are no special conditions for storage of the drug. It should be stored in original original packaging and out of the reach of children.