Ramipril tabs 5mg #30

Ramipril instruction for use

Reed more and buy Ramipril on this page

Composition

Depending on the form of release, one capsule contains 2.5, 5 or 10 mg. active medicinal substance ramipril.
In addition, the formulation contains such auxiliary compounds as magnesium stearate (1 mg.) And lactose monohydrate (96.5 mg.).

Form of issue

Ramipril is a capsule or tablet containing 2.5, 5 or 10 mg. of the same drug substance.

pharmachologic effect

The drug has antihypertensive, natriuretic, cardioprotective and vasodilating effect.

Pharmacodynamics and pharmacokinetics

In its essence, Ramipril is a drug related to ACE inhibitors (angiotensin converting enzyme), i.e. to a group of compounds that are actively used in the treatment of heart failure. Thanks to the medicinal effect of the drug in the human body begins to develop ramiprilate, which, in turn, inhibits the conversion of angiotensin I into angiotensin II, and also prevents the synthesis of the latter in tissues.
As a result of the action of the drug compound in the body, the concentration of angiotensin II decreases, which refers to sufficiently powerful vasoconstrictors. By eliminating negative feedback, with renin release, aldosterone secretion is reduced, thereby reducing overall peripheral vascular resistance.
At the same time, tolerance to exercise increases due to an increase in heart volume per minute and resistance in the vessels of the lungs. The medicine affects the vessels of the kidneys, and also starts the process of remodeling the cardiovascular system. Ramipril reduces the overall resistance of the peripheral vessels of the kidneys, muscles, liver, skin and brain, contributing to increased blood flow in the organs.
The antihypertensive effect of the drug begins just a few hours after its administration. With regular use of the drug for 4 weeks, there is a gradual increase in antihypertensive activity, the normal level of which persists with long-term treatment for several years.
The drug reduces the incidence of repeated strokes, myocardial infarction in patients after previous seizures or suffering from peripheral vascular disease, as well as CHD. In addition, the drug helps to avoid the development of diabetes in patients who have a history of such risk factors as hypertension, microalbuminuria, elevated cholesterol and decreased HDL (high-density lipoproteins).
Ramipril is absorbed by 60% in the body, and meals absolutely do not affect the degree of absorption of the drug. For effective medicinal action of the drug, the patient must correctly operate the liver, in which ether bonds are destroyed, and ramiprilate is formed, which accelerates the formation of metabolites.
After 2 hours after taking the drug in the body, the maximum concentration of the active compound is reached, which is completely eliminated after 17 hours with feces and urine.

Indications for use

Use the drug is recommended when:
    heart failure of a chronic nature;
    diabetic nephropathy, kidney disease, which is diffuse (nondiabetic nephropathy);
    arterial hypertension;
    a decrease in the likelihood of myocardial infarction, stroke, coronary death.
In addition, Ramipril is used in the treatment of patients who have had a heart attack, stroke, as well as transluminal angioplasty and coronary artery bypass graft.

Contraindications

It is not recommended to use the drug in case of hypersensitivity to substances-ACE inhibitors, hypotension, hyperkalemia, renal insufficiency, and also during pregnancy and lactation. In addition, it is recommended to avoid Ramipril in the treatment of children under the age of 18 and elderly patients.
Limit the use of the drug is in the presence of a history of angioedema, suppression, severe forms of autoimmune diseases, poor blood circulation, atherosclerosis, stenosis, kidney transplantation, diabetes mellitus and some lung diseases, hyponatremia, dialysis.

Side effects

During the drug administration, side effects such as heart failure, hypotension, angina pectoris, myocardial infarction, syncope, vertigo, arrhythmia, vasculitis, thrombocytopenia, nausea and vomiting, diarrhea, dispersion, constipation, pancreatitis, dysgraphia, impaired liver function, jaundice may occur. , increased salivation, dizziness and headaches, asthenia, amnesia, depressive states, drowsiness, neuropathy, tremor, sleep disorders, hearing loss, liver necrosis, vision impairment, cough, dyspnea, sinusitis, pharyngitis, rhinitis, laryngitis, photosensitization, as well as weight loss, angioedema, fever.

Instructions for use of ramipril (Method and dosage)

In accordance with the instruction for the use of ramipril, the drug is taken internally at a dose not exceeding 2.5 mg. per day. The mode of use of the drug, as well as the dosage, can vary depending on the prescriber's appointments, as well as on the complexity of the disease and the condition of the patient.

Overdose

In case of overdose, the following symptoms are observed in patients: hypotension, angioedema, circulatory disturbance, infarction in conjunction with thromboembolic complications.
To treat the consequences of improper dosing of the medicinal product, the stomach is washed, measures are taken to increase the volume of circulating blood, and also completely stop or lower the dose of ramipril.

Interaction

The therapeutic effect of the drug significantly strengthens antihypertensives. To avoid hypoglycemia, hyperaldosteronism, increased risk of developing neutropenia, the drug is not used in conjunction with antidiabetic drugs, diuretics, as well as myelodepressive agents, potassium supplements and salt substitutes.

Terms of sale

You can buy Ramipril without prescription.

Storage conditions

The medicine is stored in a place protected from humidity and light, for children inaccessible at a temperature of 25 ° C.
Shelf life - 3 years.

special instructions

Before starting the use of the drug, as during the treatment itself, it is recommended that patients (especially those with diffuse connective tissue diseases, as well as taking allopurinol and immunosuppressants) undergo a regular examination of the kidneys and electrolyte blood, including peripheral blood.
Patients with sodium deficiency before the start of therapeutic treatment should normalize the water-electrolyte indices. During the period of drug use it is prohibited to conduct hemodialysis with polyacrylonitrile membranes.

Children

It is not used in the treatment of children under the age of 18 years.

During pregnancy (and lactation)

Since the drug has a negative effect on the development of the fetus, especially in the first trimester, it is strictly contraindicated for use during pregnancy. If the patient becomes pregnant immediately during treatment, immediately stop taking ramipril.

Ramipril Reviews

Most patients using the original drug, and not more cost-effective analogs, including domestic manufacturers, leave positive feedback about Ramipril. However, many note as a negative factor the presence of the drug too extensive list of side effects.