Tenoric tabs 100mg/25mg #28

Tenoric instruction for use

Reed more and buy Tenoric on this page

Composition

The composition of the drug Tenoric includes 2 active substances: atenolol and chlorthalidone. To date, this drug is available in 2 dosages.1 tablet can contain 50 mg of atenolol and 12.5 mg of chlorthalidone and 100 mg of atenolol and 25 mg of chlorthalidone, respectively. As auxiliary substances in the preparation of the corn starch, lactose, sodium lauryl sulfate, polyvinylpyrrolidone, talc, as well as isopropanol, silicon dioxide and magnesium stearate. The film membrane of the tablets consists of isopropanol, methylene chloride, hypromellose, talc, titanium dioxide, as well as vaseline oil and macrogol.

Form of issue

Tablets Tenoric are film-coated and have a white or almost white color. The form of the tablet biconvex, round and have a dividing risk on one side. Packed tablets Tenoric can both in strips, and in blisters for 28 or 100 pieces. Strips and blisters in turn are placed in cardboard packs along with an instruction in which you can find a detailed description of the drug.

pharmachologic effect

Tenoric is a combined antihypertensive drug that has a sufficiently long hypotensive effect.

Pharmacodynamics and pharmacokinetics

The combined use of atenolol and chlorthalidone has little effect on the pharmacokinetics and pharmacodynamics of each active substance of the drug.
Atenolol

Suction and distribution

When taking the drug inside the active substance atenolol is approximately 45-50% absorbed from the digestive tract. Cmax of this active substance in the blood plasma is fixed in 2-3 hours after administration. The connection with plasma proteins is rather weak and amounts to only 5-15%.

Metabolism and excretion

It is proved that atenolol is not characterized by pronounced hepatic metabolism. More than 90% of atenolol, which is absorbed into the systemic circulation, is excreted from the body in a completely unchanged form. A T1 / 2 reaches about 6-9 hours, but severe renal failure may lead to increase this figure, as the kidney is the main body through which the excretion of atenolol.
Chlorthalidone

Suction and distribution

When taking the drug Tenoric, the active ingredient chlorthalidone is inside 60-65%. absorbed from the digestive tract. Cmax is fixed in the blood plasma after about 10-12 hours. Chlortalidone has a strong association with plasma proteins, which is about 70-75%.

Excretion

Chlorthalidone is excreted by the kidneys and its T1 / 2 varies within 50 hours.

Tablets Tenoric: indications for use

In indications for the use of Tenoric, it is indicated that this drug is recommended for use in the treatment regimen:
    with arterial hypertension.

Contraindications

Tablets are not recommended for use in tablets:
    with pronounced attacks of bradycardia;
    in the presence of cardiogenic shock;
    with severe and progressive arterial hypotension;
    metabolic acidosis;
    with severe violations of peripheral circulation;
    with AV blockade of the first and third degree;
    with SSSU;
    with pheochromocytoma;
    with heart failure (acute and chronic);
    with vasospastic angina (the so-called stenocardia of Prinzmetal);
    with progressive bronchial asthma;
    with obstructive bronchitis;
    with diabetes mellitus;
    with hypoglycemia;
    with gout;
    with myasthenia gravis;
    with acute hepatitis;
    with acute renal failure;
    in children and adolescents under 18;
    with increased sensitivity to the components of the drug.

Side effects

When used in the treatment scheme of tablets, Tenoric patients may experience discomfort from the following side effects:
From the cardiovascular system:
from bradycardia, increased symptoms of heart failure, orthostatic hypotension, cold extremities, appearance of arrhythmias, AV-blockade, the symptoms of intermittent claudication, Raynaud's syndrome.
From the side of the central nervous system and the peripheral nervous system:
from confusion, dizziness, headache, mood swings, acute psychosis, hallucinations, paresthesia, sleep disorders, fatigue, lethargy, disorientation, visual impairment.
From the digestive system:
from dry mouth, gastrointestinal disorders, increasing the degree of hepatic transaminases, hepatotoxicity with intrahepatic cholestasis, nausea (related to the use of chlorthalidone), constipation, pancreatitis, anorexia.
On the part of the hematopoiesis system:
from leukopenia, purpura, thrombocytopenia, agranulocytosis, eosinophilia.
Dermatological reactions:
from alopecia, dry eyes, psoriasis-like reactions, exacerbation of psoriasis, skin rashes, photosensitization.
From the respiratory system:
from bronchospasm.
From the laboratory indicators:
from hyperuricemia, hyponatremia, hypokalemia.
Other:
from an increase in the number of antinuclear antibodies, a decrease in potency, a violation of glucose tolerance.
Nevertheless, the drug Tenoric is most often tolerated by patients well. Side effects are rare, and so weakly expressed that they are more of a transitory nature.

Tablets Tenoric: instructions for use

Adults are usually prescribed an average dose of the medicine Tenoric, which is 100 mg, and the recommended initial dose is 50 mg once a day.
Elderly most often, the drug Tenoric is prescribed in lower doses.
Patients with impaired renal function are advised to reduce the frequency of medication if necessary.
Please note that the instructions for use Tenoric contains information that after a long treatment with the drug Tenoric, the abolition must be done not abruptly, but gradually.

Overdose

When an overdose of the drug Tenoric patient may experience severe discomfort from severe bradycardia, arterial hypotension, acute heart failure, bronchospasm, seizures, increased drowsiness.
For the removal of these symptoms in some cases may need to be hospitalized in the ICU, where under the supervision of doctors, gastric lavage is performed. In the case of severe arterial hypotension and severe shock, it is recommended to administer plasma or plasma substitute, and bronchodilators should be used for bronchospasm. If necessary, hemodialysis or hemoperfusion is also performed.

Interaction

Simultaneous reception of Tenoric with dihydropyridine (nifedipine) and its derivatives may cause an increase in the risk of developing arterial hypotension, and in patients who suffer from latent cardiac failure with such a combination, serious circulatory disorders may occur.
It is also necessary to avoid simultaneous reception of cardiac glycosides and beta-blockers, so this can significantly increase the AV conduction time.
Beta-adrenoblockers can also provoke an exacerbation of ricochetial hypertension, which is typical to occur after a sharp withdrawal of clonidine. In the event that both drugs are indicated in the treatment regimen, then the use of beta-blockers should be stopped for several days before the end of clonidine administration. If it is necessary to replace clonidine with a beta-blocker, the latter is prescribed a couple of days after completion of therapy with clonidine.
Pay special attention to using beta-blockers simultaneously with antiarrhythmic drugs of the first class, since with such a combination cardiodepressant effect can be summarized.
Becoming a reason to neutralize the effect of beta-blockers and a significant increase in blood pressure can be the concomitant use of such sympathomimetic drugs as epinephrine (adrenaline), norepinephrine (norepinephrine).
Reduce the hypotensive effect of beta-blockers and substances such as ibuprofen, indomethacin, which refer to salicylates and NSAIDs. By the way, the use of large doses of salicylates increases the toxic effect of these substances on the central nervous system.
From taking medications that contain lithium, you should also opt out while using diuretics. This combination causes a decrease in renal clearance of lithium.
Increased risk and rapid development of arterial hypotension can trigger a combination of beta-adrenoblockers and funds for general anesthesia. B There is also a risk of intensifying the actions of curare-like muscle relaxants.
When taking the drug, Tenoric together with MAO inhibitors causes an increase in blood pressure.
With the joint administration of tablets Tenoric and ACE inhibitors (captopril, enalapril) at the initial stage of therapy, a sharp increase in the antihypertensive effect can occur.
With the combination of Tenoric and GCS, amphotericin B, furosemide, potassium excretion is enhanced.
The effect of insulin and the effectiveness of oral hypoglycemic agents may decrease with simultaneous use with Tenoric. This is why patients who take these medications need regular blood glucose monitoring.
Such antihypertensives as tricyclic antidepressants, phenothiazines, as well as barbiturates, diuretics and vasodilators can enhance the antihypertensive effect of Tenoric tablets.
The use of beta-blockers along with calcium channel blockers has a negative inotropic effect and leads to the potency of this effect. Especially cautious in this case should be patients who suffer from reduced contractile function of the myocardium and violations of sinoatrial and AV conduction, since such a treatment regimen can cause severe arterial hypotension, severe bradycardia and heart failure. Be careful! Do not use the calcium channel blocker for 48 hours after the beta-blockers have been withdrawn.
Expressed bradycardia can also occur with the joint appointment of Tenoric and reserpine, clonidine, guanfacin.
Pay special attention to the fact that taking two or more drugs can either weaken or enhance each other's effectiveness.

Terms of sale

You don't need a prescription to buy Tenoric.

Storage conditions

Tablets Tenoric should be stored in a dry, cool, completely sheltered from the sun. Care should be taken to ensure that the drug is inaccessible to children and adolescents. The recommended temperature for storage of this drug varies between 20 and 25 ° C.
Shelf life - 3 years.

Reviews of Tenoric

The average score of Tenoric on the forums is only 3.3 on a 5-point scale.
The main advantages of the drug Tenoric visitors to the forums include:
    efficiency;
    low price.
Disadvantages of this medication participants of the discussion believe that these tablets are from pressure:
    can become with prolonged treatment the cause of hair loss and impotence;
    cause seizures.
After analyzing the doctors' opinions about Tenoric at the forums, it can be concluded that before starting its application, it is necessary to consult with the treating doctor. Also reviews about Tenoric often contain a recommendation to refuse to take this medication to the elderly.
In the search engines, one of the most common questions is "Tablets Tenoric from what?" Specialists respond that these pills are used in treatment regimens exclusively for hypertension.
Information about the drug Tenoric in Wikipedia is not provided.