Yaz Plus tabs #28

Yaz Plus contraceptive tablets instruction for use

You can buy Yaz Plus on this page online

Composition

The composition of Yaz Plus (active tablets) contains the active ingredients drospirenone, ethinyl estradiol betadec clathrate, calcium levometholate.
The composition also includes additional components of lactose monohydrate, croscarmellose sodium, magnesium stearate, giprolase.
The auxiliary tablet contains the active calcium component levometholate, as well as additional ingredients of lactose monohydrate, croscarmellose sodium, giprolase, magnesium stearate.

Form of issue

Produced in the form of tablets. Active tablets have a biconvex, round shape, they are covered by a pink film membrane. On one side of the tablet there is an engraving "Z +" in a hexagon.
Auxiliary tablets have a biconvex, round shape, they are covered by an orange film membrane. On one side of the tablet there is an engraving "M +" in a hexagon.
The contour pack contains 24 active tablets and 4 additional tablets. In a cardboard box - one blister.

pharmachologic effect

Yaz Plus tablets are a low-dose oral monophasic estrogen-progestational contraceptive that includes active tablets, as well as additional tablets that contain calcium levometholate.
The contraceptive effect of the drug is achieved by suppressing ovulation and increasing the level of viscosity of cervical mucus.
Women who take such medications note that their menstrual cycle gradually becomes more regular, and on days of menstruation the soreness and intensity of discharge decreases. As a consequence, when taking the drug in women, the risk of developing iron deficiency and anemia is reduced. There is also information that the drug reduces the risk of endometrial and ovarian cancer.
The substance drospirenone, which is contained in this contraceptive, has an antimineralocorticoid effect on the body, prevents fluid retention in the body, connected with hormone dependence. Also, the substance provides anti-androgenic activity, which, in turn, ensures a decrease in the appearance of acne, improvement of the condition of the hair and skin.
The effect of drospirenone is similar to that of progesterone, which is naturally produced in the body of a woman. This point should be taken into account by those who choose a contraceptive.
Calcium is a biologically active form of folate. This component in the body is absorbed more actively than folic acid. With the regular intake of levometholate, the need for folate in the female body is met.
If the calcium of levomefolate is present in the oral contraceptive, the woman taking this drug decreases the risk of developing a neural tube defect in an unexpected pregnancy. In this case, a woman who only learned about pregnancy should immediately stop taking the Yaz Plus tablets.

Pharmacokinetics and pharmacodynamics

Drospirenone, when taken orally, is absorbed very quickly, when taken once, the highest concentration in the blood is observed after 1-2 hours. The level of bioavailability is 76-85%. Eating food on the bioavailability of the agent is not affected. It is excreted as metabolites by the kidneys and the digestive tract.
Ethinylestradiol is completely and rapidly absorbed after oral administration. The highest concentration of the drug is achieved in 1-2 hours. Its bioavailability is approximately 60% when taken orally. If food is used at the same time, the bioavailability of the substance is reduced by 25%. It is excreted from the body in the form of metabolites, through the kidneys of the gastrointestinal tract. The elimination half-life is approximately 24 hours.
Calcium levomefolat is absorbed in the body quickly, it is included in the folate pool. After taking a two-phase pharmacokinetics, a pool with a fast and slow metabolism is observed. It is excreted in unchanged form, and in the form of metabolism through the kidneys and digestive system.

Indications for use

Yaz Plus birth control pills are shown as contraceptive to those women who have hormone-dependent fluid retention. It is also used for contraception for women who need moderate-form acne therapy. Yaz Plus is indicated as a contraceptive for women who are deficient in folate. Also shown to women with severe PMS symptoms.

Contraindications

It is contraindicated to use Yaz Plus birth control pills for women who have such diseases and body conditions:
    intolerance of constituent agents or hypersensitivity to them;
    thrombosis, thromboembolism (in the anamnesis, in the current period);
    conditions that precede the development of thrombosis (in the anamnesis, in the current period);
    presence of several factors that increase the risk of developing thrombosis;
    migraine, in which neurologic symptoms are noted;
    diabetes mellitus, in which the patient has vascular complications;
    severe liver diseases, including liver failure, liver tumors (benign or malignant);
    renal failure in acute or severe form;
    Malignant tumors associated with hormone dependence, and suspected development of such formations;
    bleeding from the vagina, the causes of which are unclear;
    pregnancy and breastfeeding;
    lactose intolerance associated with heredity.
If any of the listed conditions or illnesses appear already when taking the contraceptive, you should immediately stop taking Yaz Plus.
With caution, you need to take these birth control pills if a woman has these diseases or conditions:
    presence of factors that increase the risk of developing thromboembolism, thrombosis (overweight, smoking, hypertension, hereditary propensity to thrombosis, migraine, etc.);
    diseases in which the development of peripheral blood flow disorders is possible;
    hypertriglyceridemia;
    liver disease;
    diseases, development or aggravation of which was noted for the first time during pregnancy or during the treatment with sex hormones;
    period after childbirth.

Side effects

When taking Yaz Plus, the following side effects can be noted:
    nausea, pain in the mammary glands, the appearance of periodic bleeding from the genital tract;
    migraine;
    depressive state, mood swings.
In rare cases, these side effects are noted:
    decreased sexual desire;
    thromboembolism;
    erythema multiforme;
    tumors;
    increased blood pressure;
    hypertriglyceridemia;
    impaired liver function;
    Chloasma;
    allergic reactions.

Yaz Plus, instructions for use (Method and dosage)

If a woman chooses this as a contraceptive, then his right reception is mandatory.
Instruction for Yaz Plus provides for oral taking of tablets according to the order indicated on the package of the drug. A woman should know exactly how to take pills: they do not need to be chewed, you need to drink a small amount of liquid. You should try to use the tablets at about the same time.
Daily, for 28 days, you should drink 1 tablet. After the packaging is completed, you need to immediately open the next one.
Begin taking pills on the first day of the monthly cycle, that is, on the first day of bleeding.
If a woman has diarrhea or vomiting, then the drug in connection with such disorders of the body can not be absorbed completely, so additional contraceptive protection is needed during this period.
After menopause, tablets are not applied.

Overdose

There is no information about the overdose of Yaz Plus. In this case, nausea, vomiting and spotting may occur. Symptomatic therapy is indicated in this case. Calcium levometholate is well tolerated by the body.

Interaction

If oral contraceptives and other drugs are taken at the same time, there is likely a manifestation of uterine bleeding or a decrease in the contraceptive effect of tablets.
With simultaneous treatment with drugs that induce microsomal enzymes of the liver, it is possible to increase the clearance of sex hormones.
When taking a number of antibiotics (penicillins, tetracycline), there may be a decrease in intestinal hepatic recirculation of estrogens. As a consequence, the concentration of ethinylestradiol decreases.
If a woman takes medications that affect microsomal liver enzymes, then at this time, and also within 28 days after the cessation of such treatment, additional contraceptive means should be used.
During the treatment with antibiotics and for one week after their withdrawal, additional contraceptives should be used (except Rifampicin, Griseofulvin).
When taking some medicines, the effectiveness of calcium levomolephate may decrease. These are trimethoprim, methotrexate, sulfasalazine, triamterene, chlestyramine, phenytoin, carbamazepine, primidone, phenobarbital, and others.
Folates alter the pharmacokinetics or pharmacodynamics of a number of medications.

Storage conditions

The product should be stored at a temperature of no more than 25 ° C. It is necessary to protect tablets from children's access.
Shelf life - You can store 5 years

special instructions

It is necessary to compare the level of risk and benefit in the presence of some diseases in a woman going to use Yaz Plus for the purpose of contraception.
Admission funds can mask the presence in the body of vitamin B12 deficiency.
If there was a missing tablet, then for 24 hours, a decrease in the contraceptive effect is not observed. You need to drink a pill right after the woman remembers it. Even if you have to take two tablets at the same time, the missed pill can not be ignored. More than two tablets a day can not be taken.
If a woman misses the pill, and during the consumption of inactive pills, she does not have bleeding, a pregnancy test should be performed.
In the process of Yaz Plus reception, bloody discharge may occur. Most often it happens in the first months of taking the remedy.
Yaz Plus does not provide protection against HIV infection and sexually transmitted diseases.
Yaz Plus does not pay attention to the severity of psychomotor reactions.

Analogues of Yaz Plus

Analogues of the Yaz Plus drug are the contraceptives Midiana, Yaz, Yarina, having a similar effect on the woman's body. Despite the fact that the influence of all these means is similar, it is advisable that the doctor selects a doctor individually on a contraceptive.

Children

The drug is not assigned to children, and teenage girls can take Yaz Plus only after the first menstruation.

With alcohol

By combining Yaz Plus and alcohol, women often fear that the contraceptive effect of tablets may be reduced. Specialists note that alcohol in small doses does not reduce the contraceptive effect of tablets. But when taking oral contraceptives it is forbidden to abuse alcohol. In case of an alcohol overdose, it is necessary to additionally use other contraceptives

In pregnancy and lactation

During pregnancy, pills can not be taken. If the woman was protected with the help of Yaz Plus, and the pregnancy does come, immediately stop taking the contraceptive. In this case, the pregnancy continues to develop normally. When lactating, Yaz Plus is also contraindicated, since tablets can change the composition of milk or affect its amount.

Reviews about Yaz Plus

Reviews of doctors about Yaz Plus are usually positive, as experts note the high effectiveness of the contraceptive, as well as the fact that side effects during its reception are relatively rare. Women taking Yaz Plus pills, the reviews also leave mostly positive. It is noted the convenience of taking the drug, its effectiveness. But in some cases it is nevertheless noted that after several days of taking the pills, nausea, headache, mood swings developed. If the non-observance of the correct regimen of the medication was followed by a pregnancy after Yaz Plus, women's testimonies indicated that in the future the fetus developed normally.