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Advantan emulsion 0.1% 20gr

rating
  • $29.34
  • 3 or more $28.99
  • Availability:In Stock

Advantan emulsion instructionYou can buy Advantan emulsion hereComposition1 g of emulsion contains:The active ingredient is methylprednisolone aceponate 1 mg.Excipients:Medium chain triglycerides, softizan 378, polyoxyethylene-2-s..

Advantan emulsion instruction

You can buy Advantan emulsion here

Composition

1 g of emulsion contains:
The active ingredient is methylprednisolone aceponate 1 mg.
Excipients:
Medium chain triglycerides, softizan 378, polyoxyethylene-2-sterol alcohol, glycerin 85%, benzyl alcohol, disodium edetate, purified water.
Description
White opaque emulsion.
Pharmacotherapeutic group
Glucocorticosteroid for topical application
ATX Code D07AC14

Pharmacological properties

The active component of the drug Advantan emulsion - methylprednisolone aceponate - is a non-halogenated synthetic steroid.

Pharmacodynamics

With external use, Advantan emulsion suppresses inflammatory and allergic skin reactions, as well as reactions associated with increased proliferation, which leads to a decrease in objective symptoms (erythema, edema, wetness) and subjective sensations (itching, irritation, pain).
When applying methylprednisolone aceponate is external in the effective dosage, the systemic effect is minimal in both humans and animals. After multiple application of Advantan emulsion on large surfaces (40-60% of the skin surface), as well as the use of an occlusive dressing, there are no violations of the adrenal function: the level of cortisol in the plasma and its circadian rhythm remain within normal limits, the level of cortisol in the daily urine does not decrease.
Methylprednisolone aceponate (especially its main metabolite - 6? -Methylprednisolone-17-propionate) binds to intracellular glucocorticoid receptors. The steroid-receptor complex binds to specific regions of DNA, thus causing a series of biological effects.
In particular, binding of the steroid-receptor complex to DNA leads to the induction of macrocortin synthesis. Macrocortin inhibits the release of arachidonic acid and, thereby, the formation of inflammatory mediators such as prostaglandins and leukotrienes. Inhibition of glucocorticoid synthesis of vasodilating prostaglandins and potentiation of vasoconstrictive action of epinephrine lead to a vasoconstrictive effect

Pharmacokinetics

Methylprednisolone aceponate is hydrolyzed in the epidermis and dermis. The main and most active metabolite is 6? -Methylprednisolone-17-propionate, which has a much higher affinity for corticoid skin receptors, indicating its "bioactivation" in the skin. Intensity of absorption through the skin with artificial inflammation was very low (0.27% dose) and was slightly higher than through healthy skin (0.17%). Absorption through the skin with the removed stratum corneum was significantly higher (15%) than the dose. In case of treatment of the whole body (for example, with sunburn), the systemic dose is about 4 μg per 1 kg of body weight per day, which excludes systemic effects.
After entering the systemic circulation, 6? -Methylprednisolone-17-propionate is rapidly conjugated to glucuronic acid and is thus inactivated.
Metabolites of methylprednisolone aceponate (chief among which is 6? -Methylprednisolone-17-propionate-21-glucuronide) are eliminated mainly by the kidneys with a half-life of about 16 hours. Methylperdnisolone aceponate and its metabolites are not cumulated in the body.

Indications for use

"Acute inflammatory skin diseases in adults and children from the age of 4 months: atopic dermatitis, neurodermatitis, contact dermatitis, true eczema, seborrheic eczema, microbial eczema, disgidrotic eczema, degenerative eczema." Solar dermatitis (severe sunburn) .

Contraindications

"Tuberculosis or syphilitic processes in the field of application of the drug." Viral diseases (eg, chicken pox, shingles) in the area of ​​application. "rosacea, perioral dermatitis in the application area." Skin reactions to vaccination in the application area. "Hypersensitivity to the components of the drug.

Pregnancy and lactation

If you need the use of Advantan emulsion during pregnancy and lactation, you should carefully weigh the potential risk and the expected benefits of treatment. During these periods, long-term use of the drug on extensive skin surfaces is not recommended. In nursing mothers, the drug should not be applied to the mammary glands.

Dosing and Administration

The drug is applied once a day (to treat sunburn 1, maximum 2 times a day) with a thin layer on the affected area, gently rubbing. Usually the course of treatment should not exceed 2 weeks.
If the skin is excessively dry when using the Advantan emulsion, it is necessary to switch to a higher fat form (Advantan ointment or Advanthan oily ointment).

Side effects of Advantan emulsion

Usually the drug is well tolerated.
Sometimes, the Advantan emulsion can cause the appearance of local symptoms, such as itching, burning, erythema, dry skin, peeling or blistering.
As with the external application of other glucocorticosteroids, in rare cases, folliculitis and allergic reactions may occur.

Drug Interactions

Not described.

Overdose

In the study of the acute toxicity of methylprednisolone aceponate, there was no risk of acute intoxication with excessive single skin application (application of the drug over a large area under conditions favorable for absorption) or unintentional ingestion.

special instructions

In the presence of bacterial dermatoses and / or dermatomycosis, in addition to therapy with Advantan emulsion it is necessary to carry out specific antibacterial or antimycotic treatment.
Avoid contact with the eyes.
After repeated application neither in children nor in adults Advantan emulsion on large surfaces (40-60% of skin surface), as well as application for occlusive dressing, there are no violations of adrenal function. However, the Advantan emulsion should not be used for occlusive dressing. It should be borne in mind that diapers (diapers) can create an occlusive effect. As with systemic corticosteroids, glaucoma may develop following the administration of local corticosteroids (eg, after large doses, or very long-term use, the use of occlusive dressings or application to the skin around the eyes).

Influence on the ability to drive and use mechanisms

Does not affect.

Form of issue

For 5 g, 20 g and 50 g in laminated aluminum tubes, sealed with screwed plastic caps. The tube together with the instruction for use is placed in a cardboard box.

Storage conditions

At a temperature not higher than 25 ° C. Keep out of the reach of children.
Shelf life - 3 years.
Do not use after expiry date.

Conditions of leave from pharmacies

You don't need a prescription to buy Advantan emulsion.

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