Alerana spray 5% 60ml
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Alerana spray instruction for useYou can buy Alerana spray on this pageForm of release, composition and packagingSpray for external use 5%.1 mlminoxidil 50 mgExcipients: ethanol, propylene glycol, purified water.pharmachologic eff..
Alerana spray instruction for use
You can buy Alerana spray on this page
Form of release, composition and packaging
Spray for external use 5%.
minoxidil 50 mg
Excipients: ethanol, propylene glycol, purified water.
With local application of minoxidil, its stimulating effect on hair growth in people with androgenic alopecia (hair thinning, baldness) was noted. Improves microcirculation, stimulates the transition of hair follicles to the active growing phase, changes the effect of androgens on hair follicles. Reduces the formation of 5-alpha-dehydrosterone (possibly, indirectly), which plays an important role in the formation of alopecia. The best effect is rendered with slight disease duration (less than 10 years), the young age of patients, bald spot in the crown of no more than 10 cm, there is at the center of more than 100 bald vellus and terminal hair. The appearance of signs of hair growth is noted after 4 or more months of application of the drug. The onset and severity of the effect may vary in different patients. A 5% solution of the drug stimulates hair growth more strongly than the 2% solution, which was noted by the increase in growth of fleece hair.
After the termination of application of the drug Alerana spray, the growth of new hair is suspended, and within 3-4 months the restoration of the original appearance is possible. The exact mechanism of action of the spray Alerana in the treatment of androgenetic alopecia is unknown. Minoxidil is ineffective in case of alopecia induced by administration of the drug, malnutrition (deficiency of iron (Fe), Vitamin A), resulting in hair styling "tight" hairstyles.
With external use, minoxidil is poorly absorbed through normal intact skin: an average of 1.5% (0.3-4.5%) of the total applied dose enters the systemic circulation. The effect of concomitant skin diseases on the absorption of minoxidil is unknown.
After discontinuation of the drug, approximately 95% of minoxidil, which enters the systemic circulation, is excreted within 4 days. The profile of metabolic biotransformation of minoxidil after external application of the drug Alerana has not been fully studied to the present.
Minoxidil does not bind to plasma proteins and is excreted by the kidneys through glomerular filtration. Minoxidil does not penetrate the blood-brain barrier.
Excreted mainly with urine. Minoxidil and its metabolites are excreted by hemodialysis.
For the treatment of androgenic alopecia (hair restoration) and stabilization of the process of hair loss in men and women.
Contraindications of Alerana spray
- hypersensitivity to minoxidil or other components of the drug;
- the age is under 18 years;
- violation of the integrity of the skin, dermatosis of the scalp.
With caution: the elderly are older than 65 years (with topical application).
Outwardly. Regardless of the size of the treated area, apply 1 ml of the solution with a dosage unit (7 strokes) 2 times a day to the affected areas of the scalp, starting from the center of the problem area. After application, wash hands.
The total daily dose should not exceed 2 ml (the dose does not depend on the size of the affected area). Patients who do not have cosmetically satisfactory hair growth when applying a 2% solution, and patients who require faster hair growth, can use a 5% solution. For men, Alerana is most effective in hair loss on the vertex, for women - with hair loss in the middle part.
Apply Alerana spray only on the dry skin of the scalp. The solution does not require flushing.
The appearance of the first signs of stimulation of hair growth is possible after applying the drug 2 times a day for 4 months or more. The onset and severity of hair growth, as well as the quality of the hair, can fluctuate in different patients.
According to individual reports, recovery of the initial appearance can be expected within 3-4 months after discontinuation of treatment.
The duration of treatment on average is about 1 year.
Recommendations for using attachments:
The dispenser attached to the vial is better suited for applying the solution to large problem areas of the scalp.
To apply the product to long hair or small areas of the scalp, it is more convenient to use an elongated spray nozzle. To do this, remove the dispenser attached to the vial and strengthen the extended spray nozzle.
Side effects of Alerana spray
Local side effects:
The side effects observed in the clinical studies of the Alerana spray in most cases were dermatitis of the scalp.
Less frequent cases of more severe cases of dermatitis, manifested in the form of redness, flaking and inflammation.
In rare cases, headache, allergic contact dermatitis, folliculitis, hypertrichosis (unwanted hair growth on the body, including facial hair growth in women), seborrhea were noted.
The use of minoxidil can cause an increase in hair loss during the transition from the resting phase to the growth phase, while the old hair falls out, and new ones grow in their place. This temporary phenomenon is usually observed after 2-6 weeks after the start of treatment and gradually stops within the next two weeks (the appearance of the first signs of the action of minoxidil).
Systemic side effects (with accidental ingestion):
Dermatological diseases: nonspecific allergic reactions (skin rash, urticaria), edema of the face.
Respiratory system: shortness of breath, allergic rhinitis.
Nervous system: headache, dizziness, vertigo, neuritis.
Cardiovascular system: pain in the chest, fluctuations in blood pressure, palpitations, changes in the rhythm of the heart, swelling.
Accidental ingestion of Alerana spray can cause systemic side effects due to the vasodilating properties of minoxidil (5 ml of a 2% solution contain 100 mg of minoxidil, the maximum recommended dose for adults in the treatment of hypertension, 5 ml of a 5% solution contain 250 mg of minoxidil, ie a dose of 2.5 times the maximum recommended daily intake for adults in the treatment of hypertension).
Signs of an overdose: fluid retention, lowering blood pressure, tachycardia.
Treatment: diuretics may be prescribed to eliminate fluid retention if necessary; for the treatment of tachycardia - beta-blockers.
To treat hypotension, you should inject intravenously 0.9% solution of sodium chloride. Do not prescribe sympathomimetic drugs, for example, norepinephrine and epinephrine, which have excessive cardiostimulating activity.
There is a theoretical possibility of strengthening orthostatic hypotension in patients receiving concomitant treatment with peripheral vasodilators, which, however, did not receive clinical confirmation. We can not rule out a very slight increase in minoxidil in the blood of patients suffering from hypertension and taking minoxidil inwards in the case of simultaneous use of Alerana's drug, although relevant clinical studies have not been conducted.
It has been established that minoxidil for external use can interact with some other drugs for external use. The simultaneous use of a solution of minoxidil for external use and cream containing betamethasone (0.05%) leads to a decrease in the systemic absorption of minoxidil. Simultaneous use of cream containing tretinoin (0.05%) leads to increased absorption of minoxidil.
The simultaneous application of minoxidil to the skin and preparations for external use such as tretinoin and dithranol, which cause changes in the protective functions of the skin, may lead to an increase in the absorption of minoxidil.
Do not apply the drug to other parts of the body.
With caution: the elderly are older than 65 years (with topical application).
Conditions of leave from pharmacies
The prescription is not required to buy spray Alerana.
Terms and conditions of storage
Store in a dry place, protected from light, out of reach of children, at a temperature of no higher than 25 ° C.
Shelf life. 2 years. Do not use after expiry date.