Salicylic acid 2% 40ml

Salicylic acid instruction

You can buy Salicylic acid here

Composition

One hundred grams of alcohol solution contains 1 or 2 grams of salicylic acid.
As an excipient in the composition of the drug is 70% ethyl alcohol.
One hundred grams of ointment contains 2 or 3 grams of salicylic acid, as well as petroleum jelly in an amount up to 100 grams.

Release form

Pharmacological forms of the drug:
    alcohol solution of salicylic acid (1%, 2%, 3%, 5% and 10%; available in glass bottles of 25 or 40 ml);
    salicylic acid ointment (2%, 3%, 4%, 5% and 10%; 25 grams are packaged in cans of dark glass or aluminum tubes).

pharmachologic effect

Antiseptic for external use. It has a local irritating, keratolytic and antiseptic effect. It prevents the breakdown of proteins into amino acids, suppresses inflammation, helps to clean the wound surface and accelerates the healing of tissues.

Pharmacodynamics and pharmacokinetics

When used as a local remedy, it has a distracting, irritating, as well as weak antiseptic effect. In low concentrations provokes keratoplastic, in high - keratolytic effect.
Plasma concentration of salicylic acid reaches a maximum after 5 hours after application of the drug on the skin under an occlusive dressing. In its unchanged form, approximately 6% of the total absorbed amount of the substance is excreted in the urine, while most of it is excreted in the form of metabolic products.

Indications for use

As a monotherapeutic agent and as part of combined preparations, the agent is used:
    in various types of skin disease, including dis- and hyperkeratosis, psoriasis, ichthyosis, burns, acne, oily seborrhea, eczema, warts, calluses, pityriasis;
    with hyperhidrosis of the feet;
    with hair loss.

Contraindications

Children's age (salicylic acid ointment) and individual sensitivity to the drug. The solution is allowed to use in children older than 12 months.

Side effects

Possible local and allergic reactions.

Salicylic acid: instructions for use

In accordance with the instructions on salicylic acid, the solution is used externally. It is recommended to treat the affected surface twice a day.
The medicine is applied with a cotton swab. To handle an area the size of a palm, no more than 5 ml of solution is required. The highest dose for adults - 2, for children - 0.2 grams per day. The course of treatment is not more than 7 days.
In otorhinolaryngological practice, it is recommended that the solution be instilled into the diseased ear twice a day, 6 drops.
For acne, 1% Salicylic Acid is usually used. Two- and three-percent solution is suitable only for people with oily skin. In the presence of several acne remedy is applied point on each of them. If there are many acne, wiping the entire surface of the skin with a cotton swab moistened with a solution is shown.
The procedure continues until a slight tingling sensation appears. After treatment, the face can be rinsed with water to neutralize the action of the acid.
In case of Deverzhi disease, psoriasis, seborrhea, ichthyosis, the use of salicylic acid 2 percent in the form of an ointment is indicated. In severe inflammation, the drug should be diluted with petroleum jelly 2-4 times. The multiplicity of applications - 1-2 times a day. After peeling treatment continues with the use of other means.
On the wound surface ointment is applied in a thin layer. The treated surface is covered with sterile gauze. It is also allowed to put a napkin soaked in ointment on a wound.
Before you apply a bandage, you should open the blisters, clean the wound from necrotic tissue and wash it with an antiseptic.
The dressing is recommended to be changed every 2 or 3 days, until the wound is completely cleared of purulent and necrotic masses. The duration of treatment can vary from 1 to 3 weeks.

Overdose

Not identified.

Interaction

Salicylic acid is able to increase the permeability of the skin for other medicines for topical use and, accordingly, increase their absorption.
Absorbed Salicylic Acid may potentiate the side effects of sulfonylurea derivatives, oral hypoglycemic agents and Methotrexate.
The solution is pharmaceutically incompatible with zinc oxide (forms insoluble zinc salicylate) and with resorcin (forms melting mixtures).

Terms of sale

You can buy Salicylic Acid without a prescription.

Storage conditions

Store in a place protected from sunlight and moisture (for ointment). Keep out of the reach of children. Storage temperature for the solution - up to 15 ° C, for ointment - up to 20 ° C.

Shelf life

The solution is considered suitable for use within 3 years, ointment - within 2 years after the date of issue.

special instructions

What is salicylic acid?

In the Pharmacopoeia, salicylic acid is described as an odorless, poorly soluble substance in cold water, which can be in the form of needles without color and odor, or a white crystalline powder.
Salicylic Acid Structural Formula — Salicylic Acid Structural Formula
The empirical formula is C7H603. The systematic name of the compound is 2-hydroxybenzoic acid.

Getting

For the first time the substance was isolated in 1838 from willow bark. Hence, its traditional name is salicylic acid: in Latin the word “willow” sounds like “salix”. The discovery belongs to the Italian chemist R.Piria.
The scientist was able to divide the bitter glycoside salicin contained in willow bark into 2 parts, to reveal that its acid component (salicylic acid) has valuable healing properties, determine its chemical composition and successfully synthesize it. This can be considered the first purification of the substance that triggered the development of the drug Aspirin.
For medical use (chemically pure and in a stable form), acetylsalicylic acid samples were first obtained on August 10, 1897 by the German scientist F. Hoffman.
Salicylic acid derivatives are methyl salicylate, lysine acetylsalicylate, acetylsalicylic acid, salicylamide, mesalazine, choline and sodium salicylates.

Chemical properties

The chemical properties of the compound are due to the presence of the phenolic hydroxyl, benzene core and carboxyl group in the salicylic acid molecule.
Only the carboxyl group enters into reaction with alkali metal carbonates. As a result, salts are formed - salicylates.
With alkalis, with a sufficient amount of them, both hydroxyl and carboxyl groups enter into the reaction.
Under the action of acids on alcohols (for example, methyl) in the presence of mineral acids, esters of the COOH-group are formed.
When a substance interacts with acid anhydrides or acid halides, phenolic hydroxyl reacts. The reaction of salicylic acid (c. Acid) with anhydride or chlorohydride of acetic (ethanoic) acid allows to obtain acetylsalicylic acid.
When interacting with phosphoryl chloride, salicylic acid anhydride is formed.
If the resulting acid chloride reacts with phenol, salicylic acid phenyl ester is obtained, which is used in medicine as a disinfectant. The main feature of the tool is that it does not undergo hydrolysis in the acidic environment of the stomach and disintegrates only in the intestinal tract.
For industrial production of salol with. acid and phenol are heated in phosphoryl chloride.
The benzene core of the compound may enter into SE reactions with H2SO4, HNO3, halogens, and other electrophilic reagents. The effect of the OH group makes the aromatic core. acid is much more active to these reactions in comparison with the benzene core of C (H₅COOH (benzoic acid).
C. Acid easily reacts with an aqueous solution of bromine, whereas C₆H₅COOH does not discolor bromine water under similar conditions.
To obtain n-aminosalicylic acid (PAS), which is one of the most significant derivatives of c. acids, as a starting material, resorcinol is used. Initially, resorcinol is affected by ammonia (NH3), which allows to obtain meta-aminophenol. Then, meta-aminophenol is carboxylated into PAS by the Kolbe-Schmitt reaction.

Physical properties

Powder / crystals are difficult soluble in cold water, but readily soluble in hot water, diethyl ether, ethanol. Slightly soluble in carbon disulfide. Solubility in water (g / l): 0 ° C; 20 ° C - 1.8; 60 ° C - 8.2; 80 ° C - 20.5.
Qualitative reactions for the determination of salicylic acid
C. Acid and most of its derivatives give an intense staining in purple with iron salts Fe + 3 (ferric iron). For carrying out the reaction take a small amount of powder with. acid and drip on it a slightly dilute solution of Fe + 3 chloride.
Solution with acid, in which a few drops of copper sulphate (Cu2SO4) were added when heated, gives a bright emerald green color.
Cobert may also be used to detect a substance. To prepare it, 3 drops of formalin are carefully added to 3 ml of concentrated H2SO4.
A little salicylic acid is put on a glass slide, then 2 drops of H2SO4 are added to it and, after a few minutes, 1 drop of Cobert reagent. As a result of this reaction, the powder should turn pink.

What is salicylic acid in cosmetology?

Salicylic acid has long and very successfully been used in cosmetology. It has antibacterial properties, treats inflammatory skin lesions well, dries it, but does not cause irritation.
The effectiveness of salicylic acid for the face due to the keratolytic properties of the drug - the tool perfectly exfoliates layers of old dead skin cells, penetrates deep into the pores and eliminates blockage of the excretory ducts of the sebaceous glands, thereby helping to get rid of black spots and acne.
In addition, the drug is used:
    for peeling;
    against ingrown hairs;
    from corns;
    as a peeling agent for heels;
    from warts;
    from natoptyshy.
Salicylic acid from acne should be taken with a one percent (maximum two percent) concentration. Using too concentrated a solution can cause severe irritation.
It should be remembered that the solution of salicylic acid for acne is suitable only for people with normal and oily skin. People with dry and flaky skin are not recommended to use this product.
Some try to reduce the severity of these phenomena by applying a nourishing cream to the skin after applying an alcohol solution. However, the treatment in this case, most likely, will not be sufficiently effective: the oily film will create a protective barrier for the microbes, and this in turn will not eliminate inflammation.
Reviews indicate that the use of salicylic solution in acne gives an excellent, but short-term result. Usually, after a couple of months of using the product for face and body, the skin “gets used” to it. Therefore, between courses of treatment it is necessary to take short breaks.
If there is a little acne, the solution is spotted. If the affected area is extensive, the problem areas are wiped with a swab moistened with the product. It is better to take several tampons in order not to spread the infection.
Salicylic can be used as an independent tool, and as part of various chatterboxes. To prepare them for salicylic acid, Levomycetin, Streptocide, Camphor alcohol, calendula tincture, Trichopol, Erythromycin, zinc oxide, sulfur, and boric acid solution are added.

Popular recipes for homemade talkers for acne:

    50 ml of salicylic acid solution, powdered tablets of streptocide (7 g), 7 g of sulfur and 50 ml of boric acid solution;
    packing aspirin, packing chloramphenicol, tincture of calendula (before use, the mixture is infused for 24 hours);
    10 tablets of streptocide, 4 tablets of chloramphenicol, 30 ml of salicylic acid, 80 ml of camphor alcohol;
    1 bottle of salicylic alcohol, 2 tablets of chloramphenicol and trihopol.
All talkers before use should be well shaken.
To ensure that the effect is sustainable, in addition to local acne treatment, it is recommended
    revise the diet and make it more balanced;
    get rid of bad habits that adversely affect the condition of the skin;
    undergo a course of hormone therapy;
    regularly care for the skin;
    to live an active lifestyle.
In cosmetology, salicylic acid can also be used as the main agent of peeling compositions. The procedure allows not only to remove the layer of dead cells, but also to start the process of elastin and collagen production.
The procedure eliminates the signs of aging, acne, comedones, oily shine, get rid of age spots, even out skin tone and make the face smoother and fresher. Peeling can be applied on any part of the body.
Peeling mixtures with salicylic acid are of 2 types: paste and solution. The solution is more suitable for the skin of the face, the paste is recommended to be applied on the skin of the hands, body and knees.
Peeling may be superficial or superficial-median. In the first case, a mixture with a 15% concentration of the active substance is used, in the second - with a 30% concentration. Superficial peeling allows you to get rid of oily shine and rashes, clean clogged pores and normalize the work of the sebaceous glands, the surface-median is effective for eliminating acne and post-acne.
To carry out the procedure at home, you need to mix powdered 4 aspirin tablets (without shell) with 1 teaspoon of freshly squeezed lemon juice. The resulting gruel is applied to the face with a cotton swab, avoiding the skin around the eyes, and left for 10 minutes.
To remove the mask, a cotton pad is moistened in water with soda (baking soda neutralizes the acidity of the skin) and wipe the face with it through massage lines.
In dermatological practice, various pastes and creams with salicylic are widely used, as part of which, in addition to the active component, there are microelements enhancing its action. So, for example, Sulfur and Salicylic Ointment not only makes it possible to clean the skin of acne well, but also effectively fights Demodex.
From ingrown hairs use a solution of 1-2%. To get rid of the problem, it is enough daily to lubricate several times a day with the areas of the body where hair cannot penetrate the epidermis and grow under the skin.
From calluses and corns salicylic acid is best used in the form of a 10% ointment. From dry calluses, corns and cornflows, it is also advisable to use a corn plaster with salicylic.
Before you strengthen the plaster on the corns, the legs should be well-steamed (with antibacterial agent can be added) and wipe dry. A sore spot is covered with a piece of plaster of the desired size and left for 2 days. If this is necessary, the procedure is repeated 3-4 times, until the callus softens and separates completely.
Before applying the ointment, the actions are the same - feet are steamed and wiped dry. Then a patch is applied to the sore spot with a hole cut out in the middle. This should be done in such a way that the callus / natoptysh is open, and the areas of healthy skin surrounding it remain under the plaster.
Omozolyushny site is abundantly treated with ointment and covered with a patch.
For heels, salicylic acid is used with beeswax and paraffin. Taken in equal proportions, the wax and paraffin wax are melted in a water bath, then salicylic acid is added to them and mixed thoroughly. The mixture in several layers is applied on the heels and put on socks. It is best to leave a compress for the night.
In the morning heels are cleaned of wax-paraffin mixture. After that, it is recommended to make a soda bath and clean the skin with pumice.
To completely get rid of cracks on the feet are usually quite a few procedures.
Treatment of warts involves the use of salicylic acid with a concentration of from 10 to 60%. Salicylic acid from warts is used in the form of ointments, solutions and special patches. One such remedy is the salipod plaster, in which salicylic acid is contained in a 30% concentration.
Before applying the solution, you should steam out the skin on which the tumor appeared. This will soften the skin and enhance the effect of the drug. The procedure is carried out at bedtime, applying medicine directly to the affected area and avoiding areas of healthy skin. After treatment, the wart is covered with a bandage or plaster. In the morning, wash off the product.
With long-term use of papilloma softens under the action of acid and it can be easily removed with the help of pumice.
Ointment for removing warts is used according to the same principle as the solution: at bedtime, the affected skin area is steamed, after which a thin layer of the preparation is applied to the wart and covered with a bandage. In the morning the wart is treated with pumice.
Continue treatment should be until the complete disappearance of growths.
The most convenient method of treating warts is to use a patch. It is simple enough to stick it on the skin which has been previously steamed out and dried by a towel. After 2 days, the patch is removed, and the softened wart is gently removed with pumice stone. Procedures are repeated until complete removal of the wart.

Precautionary measures

Do not apply the solution and ointment on birthmarks, mucous membranes, hairy warts, as well as on warts that are on the face or in the genital area.
In case of contact with the mucous membranes, the corresponding area should be washed with plenty of water.
The absorption of the substance may increase with skin diseases that occur with superficial weeping lesions, hyperemia and / or inflammation (including psoriatic erythroderma).

Use in children

Ointment is contraindicated in children. When using the solution, it is necessary to avoid treating several skin areas simultaneously.

Salicylic acid during pregnancy

Alcohol solution is contraindicated during pregnancy and lactation. Pregnant and lactating women are allowed to use the drug solely as a remedy for corns and calluses and on a limited surface. Permissible dose - no more than 5 ml of 2% solution.

Salicylic Acid Reviews

Salicylic acid and agents based on it are very popular with dermatologists. The advantages of treatment with salicylic acid are its availability, high efficiency and the absence of pain in the patient during its use.
But there are also disadvantages:
    agents with salicylic are contraindicated in children;
    good results can often be achieved only with prolonged and systematic use;
    In some cases, prior to using the tool requires prior preparation.
However, most people consider these inconveniences very insignificant compared to how good the effect can be.
The largest number of reviews that can be found on the Internet are reviews of salicylic acid from acne. After analyzing them, we can conclude that the tool with its availability and low cost today means one of the most effective.
Kerato and seborrhea regulating shampoos with salicylic acid, as well as ointments and pastes that get rid of calluses and warts, have earned no less praise.