Ornidazole tabs 500mg #10

Ornidazole user manual

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Composition

One coated tablet contains 500 mg of Ornidazole.
The core of the tablet also includes corn starch, MCC, hydroxypropyl methylcellulose and magnesium sterate. The shell is made of hydroxypropyl methylcellulose, talc and titanium dioxide (E171).

Form release

Pills Ornidazole available in 10 pack, sealed in a blister and cardboard box.

Pharmacological action

For Liberal characteristic Antiprotozoal and antibacterial action.

Pharmacodynamics and pharmacokinetics

Ornidazole is a derivative of 5-nitroimidazole. It is believed that the mechanism of action is based on the ability of the drug to disrupt the DNA structure of sensitive microorganisms such as Giardia lamblia, Trichomonas vaginalis, Entamoeba histolytica. In addition, Ornidazole is active against some anaerobic bacteria, for example: anaerobic cocci, Clostridium spp., Fusobacterium spp., Bacteroides spp.
The drug also has cytotoxic properties, thus disrupting the processes of cellular respiration.

Pharmacokinetics

Once the tablets have been taken, there is an intense absorption from the gastrointestinal tract, to reach Cmax it takes a couple of hours. Ornidazole in the bloodstream binds to plasma proteins by 15% or more. Able to penetrate through the GEB. The half-life period is approximately 13 hours. The drug is excreted as metabolites by the kidneys (about 60-70%) and with feces (20-25%), eliminated unchanged only 5%.

Indications for use of Ornidazole

amoebiasis and other intestinal infections, the causative agent of which is Entamoeba histolytica;
giardiasis;
amoebic dysentery;
extraintestinal amoebiasis including amoebic liver abscess;
prevention of infectious processes that can be caused by anaerobic bacteria during surgical interventions on the colon or in gynecology.
There are also indications for use in infections of the genitourinary tract, the causative agent of which is Trichomonas vaginalis (trichomoniasis).

Contraindications

Hematological anomalies and pathologies of the blood system;
various lesions of the Central nervous system, for example: epilepsy, multiple sclerosis;
do not use in known hypersensitivity to any component of the drug, and pregnant women in the 1st trimester or breast feeding.

Side effect

headaches and dizziness;
gastrointestinal disorders;
the development of either a mixed sensory peripheral neuropathy;
various disorders of the Central nervous system, such as: tremor, disturbance of consciousness and coordination of movements, rigidity, convulsions.

Ornidazole, instructions for use (method and dosage)

Application for trichomoniasis

Taken orally, after a full meal 1 tablet in the morning and evening for 5 days. Dosage for children: 0.25 mg per 1 kg of weight of the child at a time.

Treatment of amoebic dysentery

The standard course of treatment is 3 days. Dosage for adults and children weighing more than 35 kg — 3 tablets (once, after dinner). If the adult's body weight is more than 60 kg, then 2 tablets should be taken in the morning and evening. If the child's body weight is less than 35 kg, the dose is taken at the rate of 40 mg per 1 kg of weight, divided into 2 admission.

Use in all forms of amebiasis

Usually the course of treatment lasts from 5 to 10 days. Dosage for adults and children weighing more than 35 kg – 1 tablet in the morning and evening. If the weight of the child is less than 35 kg, the dosage is calculated by the formula: 25 mg per 1 kg of weight once.

Instructions for use of Ornidazole with giardiasis

Dosage for adults and children weighing more than 35 kg – 3 tablets at a time (recommended in the evening). If the weight of the child is less than 35 kg, the dosage is prescribed at the rate of: 40 mg per 1 kg of weight (take once). Take the pills need 1-2 days.
If the causative agent - anaerobic bacteria, the treatment regimen is as follows: 500 mg taken every 12 hours.

Overdose

Prim Swindon of Ornidazole can lead to the development of more severe adverse reactions. Diazepam is used for relief of cramps. There is no specific antidote.

Interaction

In combination with the coumarin series anticoagulants, their effects are potentiated.
With vecuronium bromide is observed prolongation of its muscle relaxant action.

Terms of sale

To buy Ornidazole the prescription is not required.

Storage conditions

The temperature should not rise above +30 °C. it is Recommended to keep out of reach of minors.
Shelf life - five years.

With alcohol

During therapy, you can take alcohol and foods containing alcohol, as Ornidazole and alcohol are compatible (it does not inhibit enzyme aldehyde dehydrogenase).

Reviews of Ornidazole

Mostly reviews about Ornidazole positive. Many patients praise this drug, indicating that it quickly and effectively helped with genital infection, without causing adverse reactions.
Since Ornidazole appointed during pregnancy (II-III trimester) and children, many people are concerned about the question: is it an antibiotic or not? It is worth noting that Ornidazole has antibiotic action, but the course of treatment usually lasts only a few days. Of course, it is necessary to make an appointment and assess the risk and benefit in each case individually, trusting your health only to a proven qualified doctor.