Metypred 4mg #30

Metypred instruction for use

You can buy Metypred online

Metypred tablets refer to the pharmacological group of medicines as steroidal anti-inflammatory drugs. They have a pronounced anti-inflammatory activity and are used for pathogenetic and symptomatic therapy of inflammatory pathology, primarily structures and organs of the musculoskeletal system.

Form of issue and composition

Metypred tablets have a round plane-cylindrical shape, white color and dividing risk. The active substance of the drug is methylprednisolone, its content in one tablet is 4 or 16 mg. It also includes auxiliary components, which include:
    Magnesium stearate.
    Lactose monohydrate.
    Talc.
    Gelatin.
    Corn starch.
    Purified water.
Tablets are packaged in dark plastic or glass bottles of 30 or 100 pieces. Cardboard pack contains 1 bottle with the appropriate number of tablets and instructions for the use of the drug.

pharmachologic effect

Methylprednisolone is a synthetic derivative of glucocorticosteroids (hormones that are produced by the adrenal cortex). The anti-inflammatory effect of this compound is realized due to several mechanisms, which include:
    Induced decrease in the production of a number of biologically active compounds by the cells of the immune system, primarily by eosinophils and basophils.
    Stabilization of cell membranes of leukocytes, which leads to a decrease in the release of biologically active compounds that enhance the inflammatory response in tissues (mediators of inflammation).
    Inhibition of the synthesis of prostaglandins (the main mediators of the inflammatory reaction) by reducing the activation of enzymes that catalyze the conversion of arachidonic acid.
    Decrease in the concentration of leukotrienes, tumor necrosis factor in the focus of the inflammatory reaction, which also contributes to the reduction of its manifestations.
    Increased resistance (resistance) of cytoplasmic cell membranes.
By reducing the concentration of pro-inflammatory biological substances, hyperemia (increased inflammatory blood filling of tissues) decreases, pain and swelling, during the proliferation stage, methylprednisolone reduces the severity of scar tissue formation in the area of ​​cell damage. Such effects are realized in the development of various types of inflammatory reactions, including allergy and autoimmune processes. Also, the active substance of Metypred tablets has immunosuppressive action, it suppresses the functional activity of immunity due to involution (reverse development) of lymphoid tissue. Metyprednisolone affects the metabolism in the body - increases the level of glucose and cholesterol in the blood, increases the synthesis of albumins in the liver cells, promotes the retention of sodium and water in tissues.
After taking Metypred tablets inside, the active substance is quickly and almost completely absorbed into the blood from the lumen of the small intestine. It is evenly distributed in the tissues of the body, penetrates into the structures of the central nervous system through the blood-brain barrier, and also through the placenta into the developing fetus and into breast milk during pregnancy or breast-feeding. Methylprednisolone is metabolized in baking cells with the formation of inactive compounds, which are excreted from the body mainly with urine. Half-life (the time for which half of the total dose of the active substance of the drug is excreted from the body) is about 3.3-3.5 hours.

Indications for use

The Metypred tablets are taken with a number of pathological conditions accompanied by a prolonged and severe inflammatory reaction of various localizations, including allergies, which include:
    Systemic pathology of connective tissue with autoimmune inflammatory reaction - nodular periarteritis, scleroderma, rheumatoid arthritis, dermatomyositis, systemic lupus erythematosus.
    Acute or chronic inflammatory pathology of the joints and periarticular tissues of various origin - reactive, infectious arthritis, arthrosis (degenerative-dystrophic processes leading to destruction of cartilage tissue and development of chronic inflammation), bursitis (inflammation of the periarticular bags), osteochondrosis.
    Rheumatism and rheumatic carditis is an autoimmune inflammation of the connective tissue of various localizations, which can also damage the heart valves with the development of their insufficiency.
    Bronchial asthma (allergic inflammation of the bronchi accompanied by their spasm), as well as asthmatic status (marked degree of inflammatory reaction and constriction of the bronchi, accompanied by pronounced dyspnea).
    Various acute or chronic allergic reactions - urticaria (pruritus and skin rash, reminiscent of nettle burn), food and drug allergies, hay fever, pollinosis, angioedema angioedema (pronounced edema of the facial and external genital area tissues), anaphylactic shock (severe systemic allergic reaction with a marked decrease in blood pressure and the development of multiple organ failure).
    Various inflammatory diseases of the skin, its appendages and subcutaneous tissue - atopic, allergic, contact dermatitis, pemphigus, toxic epidermal necrolysis (Lyell's syndrome), exfoliative and seborrheic dermatitis.
    Allergic pathology of the eyes, including allergic conjunctivitis.
    Adrenal insufficiency of various origins, which requires replenishment of the level of its hormones in the body.
    Autoimmune pathology of the blood system and red bone marrow - a decrease in the number of platelets (thrombocytopenia), leukemia (tumor lesion of the red bone marrow with the involvement of various hematopoiesis in the process).
    Subacute thyroiditis is an autoimmune lesion of the thyroid gland.
    Nephrotic syndrome, which develops due to significant inflammatory damage to kidney tissue is more often of autoimmune origin.
    Various pathologies of the lungs - tumor (cancer), interstitial and aspiration pneumonia, pulmonary tuberculosis, alveolitis (inflammation of the alveoli).
    Multiple sclerosis is an autoimmune or infectious lesion of the nervous system, in which the gradual replacement of structures with a connective tissue develops.
    Hepatitis (inflammation of the liver) of various origins.
    Autoimmune pathology of the large intestine with the formation in its walls of inflammation and ulcerative defects - nonspecific ulcerative colitis, Crohn's disease.
    Nausea, vomiting, hypercalcemia (increased levels of calcium ions in the blood) with various oncological pathologies, as well as chemotherapy with cytostatics.
Also, Metypred tablets are used to prevent the development of immune rejection reaction after transplantation (transplantation) of organs or tissues.

Contraindications for use

The only absolute contraindication for short-term taking of Metypred tablets in order to stabilize vital indicators is the individual intolerance of the active substance. With caution, the drug is used in such cases (relative contraindications):
    Pathology of the digestive tract organs - peptic ulcer of the stomach or duodenum, inflammation of the esophagus (esophagitis) or stomach (gastritis), diverticulitis (the formation of protrusion with inflammatory reaction in the wall of the structures of the digestive tract), recently transferred surgical interventions on the organs of the gastrointestinal tract, in particular about the formation of intestinal anastomosis.
    Infectious diseases of viral, fungal or bacterial origin at the time of application of the drug or transferred in the recent past - herpetic infection surrounding herpes, amoebiasis, chickenpox, systemic mycosis, strongyloidiasis, measles, active or latent (latent tuberculosis), the use of Metypred tablets reduces the functional activity immunity, which can worsen the course of pathology.
    The period before or after vaccination (vaccination) is usually 8 weeks before and 2 weeks after vaccination.
    Postponed myocardial infarction (death of myocardium cardiac site), severe form of heart failure, hyperlipidemia (increased level of fats in the blood, which increases the risk of depositing cholesterol in the walls of arterial vessels with the formation of atherosclerotic plaques), arterial hypertension (increase in blood pressure).
    Chronic or acute course of renal or hepatic insufficiency.
    Hypoalbuminemia is a decrease in albumin levels in the blood, as well as conditions that can trigger its development.
    The pathology of the endocrine system is diabetes mellitus (type 1 and type 2), hyperthyroidism (an increase in thyroid functional activity, the extreme manifestation of which is thyrotoxicosis), obesity of grades 3 and 4, and Itenko-Cushing's disease (adrenal cortex pathology).
    Systemic osteoporosis - decrease in bone mineral density of various origin.
    Acute mental disorders (acute psychosis).
    Myasthenia gravis is a weakness of the striated muscles, including myasthenia gravis.
    Open angle or angle-closure glaucoma (increased intraocular pressure).
    Poliomyelitis is a viral lesion of the nervous system with the development of paralysis of skeletal muscles, with the exception of the bulbar form of the pathological process.
    Pregnancy at any time of its course.
The possibility of using Metypred tablets in the case of relative contraindications is determined by the doctor on an individual basis.

Dosing and Administration

Metypred tablets are taken internally as a whole after meals. They are not chewed and washed down with enough water. Usually a daily dose is taken once a day, or a double daily dose of 1 every 2 days. Treatment of the drug begins with a minimal therapeutic dose, which is then gradually increased to achieve a therapeutic effect. In the absence of the necessary therapeutic effect after taking the maximum daily dose of the drug, further use of Metypred tablets is impractical, the drug is canceled. The average therapeutic dose varies between 4-48 mg. In some severe inflammatory processes, a significant increase in the dose to 200-1000 mg per day (multiple sclerosis, acute edema of the brain, a condition after organ transplantation) is required. In childhood, the dose of the drug is determined individually. Also the mode of taking Metypred tablets, the duration of the course of treatment and the dosage are selected by the doctor individually, depending on the age of the patient, the pathological inflammatory process, as well as the characteristics of the body and metabolism.

Side effects

Taking Metypred tablets can cause the development of unwanted side reactions from various organs and systems:
    The digestive system - nausea, vomiting, flatulence (bloating), hiccups, peptic ulcer formation in the wall of the stomach or duodenum, erosive esophagitis, gastrointestinal bleeding, less often the increase in activity of enzymes of liver transaminases in the blood (ALT, AST), which indicates damage to the liver cells.
    Nervous system - disorientation in time and space, delirium (acute mental disorder with concomitant appearance of visual, auditory hallucinations against motor and speech excitement), euphoria, depression (pronounced and prolonged decline in mood, its depression), insomnia, anxiety, nervousness, headache, periodic dizziness up to the development of vertigo (pronounced, intense dizziness), increased intracranial pressure, the appearance of obsessive thoughts up to paranoia.
    Cardiovascular system - bradycardia (decrease in the frequency of cardiac contractions), arrhythmia (violation of the rhythm and heart rate), strengthening or primary development of heart failure, hypercoagulability (increased blood clotting, which increases the risk of formation of intravascular thrombi), the spread of the hearth necrosis after taking the drug against a background of myocardial infarction, as well as slowing the formation of connective tissue scar, which can lead to rupture of the muscle.
    The endocrine system is a decrease in glucose tolerance, which is accompanied by an increase in its level in the blood after eating (especially after eating sweets and other easily digestible carbohydrates), the development of steroid diabetes on the background of a prolonged increase in blood sugar level provoked by methylprednisolone, Itenko-Cushing syndrome deposition of fat in the upper half of the trunk, characteristic "moonlike" face, intensive growth of hair on the body - hirsutism), delay in sexual development in children.
    Sensory organs - posterior cataract (clouding of the lens), increased intraocular pressure with a high risk of damage to the retina of the eye and optic nerve, a tendency to develop infectious viral, bacterial or fungal lesions of the eye tissues, trophic changes in the cornea with the formation of connective tissue in it, exophthalmos eye).
    Musculoskeletal system - slowing the growth of bones in childhood, as well as the process of their mineralization, osteoporosis (decreased bone density associated with increased leaching of calcium salts) with an increased risk of developing their pathological fracture, reducing muscle mass, rupture of tendons.
    Code and subcutaneous tissue - a significant deterioration in the healing (regeneration) of skin lesions, thinning (hypotrophy or atrophy) of the skin, the appearance of petechiae (acne bleeding on the skin), acne, a tendency to pyoderma (purulent bacterial skin lesions).
    Metabolism in the body - increased excretion of calcium ions, weight gain, sweating, negative nitrogen balance (nitrogen retention in the body as a part of nitrogen-containing organic compounds), development of peripheral edema of tissues due to water retention in the body, hypernatremia (increased levels of sodium ions in the blood , which provokes a water retention in the body).
    Allergic reactions - rarely itchy skin, a rash on it, urticaria (a characteristic swelling and a rash that resemble a nettle burn), anaphylactic shock (a severe systemic allergic reaction with a significant decrease in blood pressure and multiple organ failure).
Also, the drug leads to a decrease in the functional activity of immunity, in connection with which, against the background of its use, the development of various infectious complications is possible. With the development of side effects, the question about the abolition of tablets is decided by the attending physician, depending on their severity.

special instructions

Before starting the use of Metypred tablets, you should carefully read the product summary. There are a number of specific guidelines for taking the drug, which include:
    Prolonged use of the drug requires periodic monitoring of blood pressure, peripheral blood, glucose concentration and the state of water-electrolyte balance of the body, examination by an ophthalmologist.
    In order to reduce the risk of side effects, it is recommended to take antacids and potassium-containing drugs together with Metypred tablets.
    The pharmacological and therapeutic effect of the drug is enhanced against the background of concomitant hypothyroidism and liver cirrhosis with a significant decrease in its functional activity.
    The drug provokes the spread of the foci of necrosis and slows the process of regeneration and scarring of the heart muscle after a heart attack, which must be taken into account during its appointment.
    In the presence of severe stress factors, the body's need for glucocorticosteroids is increased, so a dose adjustment is necessary.
    The use of high therapeutic doses of Metypred tablets, followed by a sharp discontinuation of their intake, can lead to the development of withdrawal syndrome, which consists in the absence of appetite (anorexia), nausea, pain in the skeletal muscles, inhibition of the nervous system and general weakness, reduce dosage.
    The administration of the drug to children requires careful monitoring of their growth and development, especially the musculoskeletal, nervous and reproductive systems.
    Use of the drug to reduce the severity of infectious inflammation requires the parallel conduct of etiotropic therapy aimed at the destruction of pathogenic microorganisms (use of antifungal, antiviral or antibacterial agents). Also, children who have had contact with patients with chickenpox, measles, rubella, mumps epidemic must be preventively administered immunoglobulins.
    If necessary, mineralocorticoid preparations are used in conjunction with Metypred tablets for replacement therapy.
    In patients with concomitant diabetes it is important to carry out periodic monitoring of blood glucose levels against the background of taking the drug.
    With prolonged use of the drug, periodic radiographic examination of the bones of the hand is recommended.
    In the presence of a latent (hidden) pathology of the kidneys, against the background of the Metypred tablets, leukocyturia (the appearance of a significant number of white blood cells in the urine) may appear, which is a diagnostic sign.
    It is not recommended to carry out immunoprophylaxis (vaccination) against the background of the drug.
    Metypred tablets can interact with a significant number of drugs from other pharmacological groups, so their doctor should be warned about their possible use.
    The drug does not have a direct effect on the functional state of the nervous system, but in connection with the possible development of side effects from the cerebral cortex, the work associated with the need for increased concentration and speed of psychomotor reactions is not recommended.
In the pharmacy network, Metypred tablets are dispensed only on prescription. It is not recommended their independent use or reception on the advice of third parties.

Overdose

If the recommended therapeutic dose of Metired tablets is significantly exceeded, development or intensification of side effects may be possible. In this case, the drug is canceled and symptomatic treatment is performed in a medical hospital.

Terms and conditions of storage

Shelf life of Metypred tablets is 5 years from the date of manufacture. The drug should be stored in a dry place inaccessible to children at an air temperature of +15 to + 25 ° C.