Jodilife tabs #28

Jodilife user manual

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Indications for use

- prevention of deficiency of iodine, folic acid and vitamin B12 (cyanocobalamin) in women of childbearing age at the stage of pregnancy planning (at least 1 month before conception);
- prevention of neural tube defects in the fetus in the first trimester of pregnancy.

Contraindications for Jodilife

- lactation period;
- childhood;
- increased individual sensitivity to the components of the drug.
- hereditary intolerance to galactose, deficiency of lactase or impaired absorption of glucose or galactose;
- acute form of bronchitis, expressed and latent hyperthyroidism (with a daily dose of potassium iodide more than 150 mg / day).
With caution appoint the drug to patients with gipokomplementemicheskim vasculitis, goitre or autoimmune thyroiditis, kidney disease, chronic hyperkalemia, active tuberculosis, epilepsy.

Dosing and Administration (Instruction)

Take inside, 1 tablet a day, before meals.
The course of preventive treatment in women of childbearing age at the stage of pregnancy planning is at least 1 month before conception and during the first trimester of pregnancy. Repeated courses are conducted on the advice of a doctor.

Pharmachologic effect of Jodilife

The action of Jodilife is due to the action of the constituent components. The use of the drug can overcome the metabolic blockade, which is observed in children with neural tube defects. The specific nature of this metabolic blockade is the metabolism of the essential amino acid methionine, in which folic acid and vitamin B12 are key elements, as they are responsible for the re-methylation of homocysteine ​​in methionine.
Folic acid belongs to the vitamins of group B, it participates in the synthesis of purines and pyrimidines, the exchange of choline, as a whole - in the metabolism of nucleic acids and proteins. It plays an important role in the formation of the central nervous system, which develops in humans on the 15-28th day after fertilization. Deficiency of folic acid causes the development of neural tube defects in the fetus.
Vitamin B inside the cell exists in the form of two active coenzymes: methylcobalamin and adenosylcobalamin. Methylcobalamin is necessary for the work of methionine synthetase, which is involved in the metabolism of folic acid. This interaction of folic acid with cobalamin is necessary for the normal synthesis of purines and pyrimidines, and therefore DNA. With a deficiency of vitamin B12 or folic acid, the reduced synthesis of methionine and S-adenosylmethionine disrupts many methylation reactions, the synthesis of proteins and polyamines.
Iodine - the main element for the synthesis of thyroid hormones, thyroxine (T4) and triiodothyronine (T3) (the mass fraction of iodine in which is 65% and 59%, respectively). Thyroid hormones are necessary at all stages of life for the normal functioning of the central nervous system. Iodine also directly affects the brain cells of the embryo.

Side effects of Jodilife

Disorders from the gastrointestinal tract: diarrhea, nausea, vomiting, swelling and abdominal pain, flatulence, metallic taste in the mouth and increased salivation.
Disorders from the endocrine system: goiter, hyperthyroidism and hypothyroidism.
Disorders from the cardiovascular system: vasculitis, periarthritis with fatal outcome.
Immune system disorders: edema (including facial edema and glottis).
Disturbances from the skin: itching, rashes and erythema, urticaria, exanthema and angioedema.
Disorders from the blood and lymphatic systems: thrombocytopenic purpura.
Other disorders: hypersensitivity, general malaise, signs and symptoms similar to serum sickness: fever, joint pain, lymphatic cyst formation and eosinophilia.
Overdose of Jodilife can manifest itself with such symptoms as metallic taste in the oral cavity, increased sensitivity of teeth and gums, increased salivation, irritation of the nasal mucosa, sneezing, swelling of the eyelids (a complex of symptoms of 'iodism'). In addition, severe headache, cough, pulmonary edema, impaired parotid and submandibular gland function, inflammation of the pharynx, larynx and tonsils, a mild skin rash in the seborrheal areas, and disorders of the gastrointestinal tract (diarrhea).
In case of an overdose, stop taking the drug and consult a doctor. Treatment is symptomatic.

Special instructions

It should be borne in mind that antibiotics can distort (give low results) the results of analysis of the concentration of folic acid plasma and erythrocytes. In view of the influence of iodides on the thyroid gland, taking these medications can lead to a distortion of the results of thyroid function tests.
Do not take a double dose of the drug if you missed the next appointment.
The application of Jodilife does not affect the performance of potentially hazardous activities requiring special attention and quick reactions (vehicle management, working with moving mechanisms, dispatcher and operator work, etc.).

Interaction

The drug should not be taken concurrently with methotrexate, pyrimethamine, triamterene, trimethoprim, because they act as antagonists of folic acid, inhibiting tetrahydrofolate reductase.
The use of Jodilife in combination with antiepileptic drugs from the hydantoin group (phenytoin) can reduce the effect of the latter.
Analgesics (with prolonged therapy), estrogens and oral contraceptives increase the need for folic acid.
Antacids (including preparations of calcium, aluminum and magnesium), colestyramine, sulfonamides (including sulfasalazine) reduce the absorption of folic acid.
Simultaneous use of the drug with potassium-sparing diuretics can lead to a decrease in the excretion of potassium by the kidneys, as a result of which there is a possibility of severe chronic hyperkalemia.
Concomitant intake of lithium and potassium salts can lead to hypothyroidism.
Simultaneous use with antithyroid drugs can lead to increased hypothyroidism.

Terms of sell

To buy Jodilife the prescription is not required.