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Britomar tabs 10mg #30

rating
  • $24.28
  • 3 or more $23.99
  • Availability:In Stock

Britomar instruction for useReed more and buy Britomar on this pageCompositionIn 1 tablet of torasemide 5 mg or 10 mg. Guar gum, starch, silicon dioxide, magnesium stearate, lactose monohydrate, - as auxiliary substances.Form of i..

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Britomar instruction for use

Reed more and buy Britomar on this page

Composition

In 1 tablet of torasemide 5 mg or 10 mg. Guar gum, starch, silicon dioxide, magnesium stearate, lactose monohydrate, - as auxiliary substances.

Form of issue

Tablets with prolonged action.

pharmachologic effect

Diuretic.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The mechanism of action is the binding of torasemide to the Na +, K + and Cl transportator, which is located in the membrane of the ascending loop of Henle. As a result, renal reabsorption of sodium and chlorine decreases, the osmotic pressure within the cell decreases and the reabsorption of water decreases.
This is a loop diuretic. Virtually does not affect the level of renal plasma flow, glomerular filtration and acid-base balance. Torasemide causes less hypokalemia, in comparison with furosemide, but shows more activity. Reduces systolic and diastolic pressure.
The diuretic effect is manifested after 1 hour, the maximum reaches 4-6 hours. In general, the effect of the drug Britoman continues up to 10 hours.

Pharmacokinetics

The drug Britomar has a prolonged action due to the gradual release of the active substance torasemide, which prevents a sharp decrease in its concentration in the blood. After taking the tablets for several days, bioavailability is 102%. Well absorbed from the digestive tract. Cmax in the blood is determined after 1.5 hours. About 99% of the drug binds to proteins. Metabolised in the liver with the formation of 3 metabolites, which are pharmacologically inactive. The half-life is 4 hours. Most of the drug is excreted by the kidneys.

Indications for use

    Edematous syndrome with CHF, liver and kidney diseases.
    Hypertension.

Contraindications

Britomar is contraindicated in the following conditions:
    disturbances of outflow of urine;
    anuria;
    hepatic coma;
    dehydration of the body;
    refractory hypokalemia and hyponatremia;
    intoxication with cardiac glycosides;
    AV blockade II and III degree;
    acute glomerulonephritis;
    pregnancy;
    deficiency of lactase;
    age to 18 years;
    hypersensitivity.

Side effects

Before you buy Britomar you should know these side effects of the drug:
    dizziness, drowsiness;
    convulsions of the lower limbs;
    increased thirst;
    confusion of consciousness;
    tinnitus;
    numbness in the limbs;
    extrasystole, tachycardia, arterial hypotension, thromboembolism;
    nasal bleeding;
    diarrhea, abdominal pain, swelling, loss of appetite;
    increased urge to urinate, nocturia;
    skin itching, rash;
    hypercholesterolemia.

Britomar tablets, instructions for use (Method and dosage)

Britomar tablets are taken orally 1 time per day, regardless of food intake, swallowing whole, with liquid.
With edematic syndrome caused by heart failure: 10-20 mg per day. The dose can be increased 2 times, if necessary.
With edematic syndrome against a background of kidney disease: 20 mg, if necessary, increases 2 times.
With edematic syndrome caused by liver diseases: 5-10 mg + potassium-sparing diuretics. The dose can be increased 2 times, but not more than 40 mg.
With arterial hypertension: 5 mg per day. The dose is increased to 10 mg, if after 1.5 months there is no adequate reduction in blood pressure.

Instructions for use Britomar contains warnings:

    With prolonged treatment, it is necessary to monitor the electrolytes of blood, glucose, creatinine and lipids.
    For the prevention of hypokalemia, take potassium supplements and follow a diet with a high content of potassium.
    The use of the drug may provoke an exacerbation of gout.
    When taking high doses of the drug, it is inappropriate to limit or exclude salt intake, since hyponatremia may develop.

Overdose

It is manifested by symptoms: increased diuresis, which is accompanied by electrolyte disorders, decreased BCC, a sharp decrease in blood pressure, confusion.
The treatment is applied: gastric lavage, sorbent intake, drug withdrawal, restoration of water-electrolyte balance.

Interaction

The drug enhances the effect of antihypertensive drugs and the toxicity of cardiac glycosides.
In high doses increases the nephrotoxic and ototoxic effect of antibiotics, preparations of platinum, ethacrynic acid.
Increases the toxicity of lithium preparations. Strengthens the effect of Theophyllin.
Reduces the effect of hypoglycemic drugs.
Joint intake of glucocorticoids increases the excretion of potassium. When combined use of salicylates increases their toxic effect. NSAIDs and probenecid reduce the diuretic effect of the drug. Bioavailability and effectiveness decreases with the simultaneous administration of Kolestyramine.

Storage conditions

In a dry place. Storage temperature not higher than 30 ° C.
Shelf life - 3 years.

Reviews about Britomar

Discussions on the forums about the use of the drug Britomar not, and reviews are also very rare. According to patients who took this drug, it does not work quickly, and the effect increases gradually day by day. This is due to the prolonged action of the drug.
When the dose is increased, there is often a side effect - dehydration (excessive fluid loss due to increased sodium excretion). This side effect is characteristic of all loop diuretics. In humans, this was manifested by a decrease in pressure with a sharp change in the position of the trunk, dizziness, fainting, palpitation, especially at night and in the morning. With a general dehydration, the turgor of the skin decreased, there was a pronounced dryness in the mouth. In this case, doctors recommended to cancel the drug, increase the amount of water consumed and table salt.
It is believed that the slow release form of the substance is more acceptable, because it limits human activity to a lesser extent, does not violate the habitual way of life and is suitable for long-term admission in outpatient settings. It is a soft drug with prolonged action and is well tolerated by patients, especially in cases where prolonged therapy is expected.

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