Lotonel tabs 10mg #60

Lotonel user manual

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pharmachologic effect

Torasemide is a “loopback” diuretic. The main mechanism of action of Lotonel is due to the reversible binding of torasemide to the kontransiorger of sodium / chlorine / potassium ions located in the apical membrane of the thick segment of the ascending loop of Gale, as a result of which the reabsorption of sodium ions decreases or the osmotic pressure of the intracellular fluid and water reabsorption are reduced. Thorassmide blocks aldosteroic myocardial receptors, reduces fibrosis and improves the diastolic function of the myocardium.
Due to the anti-aldistronic action, torasemide to a lesser extent than furosemide causes hypokalemia, while it is more active and its action is longer.
The diuretic effect develops about an hour after ingestion, reaching a maximum after 2-3 hours, and lasts up to 18 hours, which facilitates the tolerability of therapy due to the lack of very frequent urination in the first hours after taking Lotonel inside, which limits the activity of patients.
Thorassmid reduces systolic and diastolic blood pressure in the "lying" and "standing."
The use of thorassmid is the most reasonable choice for long-term therapy.

Lotonel, indications for use

Edematous syndrome of various genesis, including in chronic heart failure, diseases of the liver, lungs and kidneys;
arterial hypertension.

Contraindications

Hypersensitivity to torasemide or to any of the components of Lotonel;
allergy to sulfonamides (sulfanilamide antimicrobial agents or sulfonylmoxvip drugs);
renal failure with anuria;
hepatic coma and precoma;
refractory hypocalism;
refractory hyponatremia;
hypovolemia (with or without hypotension) or dehydration;
pronounced violations of urine outflow of any etiology (including unilateral damage to the urinary tract);
glycosidic intoxication:
acute glomerulonephritis;
sinoatrial and atrioventricular block II-1II degree;
decompensated aortic and peripheral stenosis;
hypertrophic obstructive cardiomyopathy;
increase in central venous pressure (over 10 mmHg);
arrhythmia;
chronic renal failure with increasing azotemia;
hyperurysmia;
age up to 18 years (safety and efficacy not established);
pregnancy;
breastfeeding period;
simultaneous use of aminoglycosides and tsfalosnorinov;
lactose intolerance, lactase deficiency or glucose-galactose unit malabsorption.

Dosage and administration

Inside, once a day, without chewing, drinking plenty of water. Tablets can be taken at any convenient constant time, regardless of the meal. The usual initial dose is 10-20 mg once a day. If necessary, the dose may be doubled to obtain the desired effect.

Side effects of Lotonel

On the part of the senses, visual impairment, hearing impairment, tinnitus and hearing loss (usually reversible), usually in patients with renal insufficiency or hypoprothism (nephrotic syndrome).
Since the cardiovascular system is infrequent - oxtrasystole, arrhythmia, tachycardia.
On the part of the respiratory system, nasal bleeding.
On the part of the digestive system: - diarrhea; abdominal pain, flatulence, polydipsia; dry mouth, nausea, vomiting, loss of appetite, pancreatitis, dyspepsia, intrahepatic cholestasis.
On the part of the knives and foot tissues - pruritus, rash, urticaria, polymorphic erythema, exfoliative dermatitis, purpura, vasculitis, photosensitization.
On the part of the musculoskeletal system, the frequency is unknown - muscular weakness.
On the part of the urinary system, an increase in the frequency of urination, noliuria, nocturia; infrequently - increased urge to urinate;
oliguria, urinary retention (in patients with urinary tract obstruction), interstitial nephritis, hematuria.
From the reproductive system - reducing potency.
From the metabolism, hypokalysmia. hyponatremia, hypomagnesmia, hypocalcemia, hypochloremia, metabolic alkalosis, hypovolemia, dehydration (more often in elderly patients).

Terms of sell

You can buy Lotonel without a prescription.