Nystatin supp 500000 #10

Nystatin user manual

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Composition

    In 1 suppository of nystatin 250 000 units or 500 000 units.
    In 1 g of ointment - 100 000 units.
    In 1 tablet -500 000 units.

Form of issue

Vaginal suppositories, tablets, ointment.

pharmachologic effect

Antifungal.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

What is Nystatin? It is an antibiotic of polyene series with antifungal activity. It is active against yeast-like Candida fungi. With respect to bacteria is ineffective. It has a fungistatic effect. The resistance of fungi to the drug develops slowly.
The structure of nystatin contains double bonds, which cause tropicity to the formation of the cell membrane of the fungi - the substance molecule is embedded in the membrane and forms channels for the transport of electrolytes into the cell. Increase in osmolality inside it leads to death. The cell lyses, losing its resistance to the effects of osmotic forces from the outside.

Pharmacokinetics

When ingestion is almost not absorbed in the digestive tract. Do not cumulate with multiple admission. It is excreted through the intestine.
The active ingredient of ointments and suppositories in external application is not absorbed through the mucous membrane and the skin.

Indications for use

For vaginal suppositories

    Candidiasis of the vulvar-vaginal area;
    prevention of fungal diseases with local antibiotic therapy.

For tablets

    prevention of fungal diseases in the postoperative period during operations on the organs of the digestive tract;
    Candidiasis of internal organs of skin and mucous membranes;
    prevention of candidiasis of the gastrointestinal tract with prolonged antibiotic therapy.

Indications for ointment application

Candidiasis of the skin and mucous membranes.

Contraindications

For all dosage forms:
    hypersensitivity;
    pregnancy.
Pills:
    abnormal liver function;
    stomach ulcer;
    pancreatitis.
Suppositories:
Age to 18 years.
Ointment:
Age before 1 year.

Side effects

    Tablets can cause nausea, vomiting, bitter taste in the mouth, diarrhea, chills, abdominal pain, allergic reactions.
    Suppositories - burning and itching, local allergic reactions.
    Ointment - a rash, irritation of the skin and mucous membranes, urticaria.

Instructions for use Nystatin (Method and dosage)

The drug has several forms of release, so we will review the instructions for the use of all dosage forms.

Nystatin tablets, instructions for use

How to take pills? Tablets are taken orally, regardless of food intake. They are swallowed without chewing. Nystatin tablets are prescribed for adults with candidiasis of internal organs at 500,000 ED 6-8 times a day. Duration of treatment up to 14 days. The average daily dose is 1500,000 - 3,000,000 units. With generalized candidiasis - up to 6 000 000 units per day, repeated courses are conducted after 2 weeks.
For children under the age of 1 year, the dose is 125,000 units, from 1 to 5 years 250,000 units, over 13 years -500,000 units, the frequency of administration 3-4 times a day. Duration of treatment is up to 14 days.

Ointment Nystatin, instructions for use

Ointment Nystatin is intended for external use, it is applied a thin layer on the skin or mucous membranes 2 times a day for 10 days. Often combine with taking tablets inside. When stomatitis in a child ointment lubricated lesions 3 times a day after meals, treatment lasts at least a week.
With the development of local irritation, skin rash or hives, the drug is canceled.

Suppositories Nystatin, instructions for use

Vaginal suppositories Nystatin is injected deep into the vagina. Dosing regimen is individual. Usually 1 candle in the morning and in the evening. Duration of treatment is 14 days. During the monthly treatment is not interrupted. During the treatment period, avoid sexual contact. Treatment of the sexual partner is necessary. When pregnancy is used Suppositories with Nystatin prescribed by a doctor for acute need.

Overdose

Overdose phenomena are not described.

Interaction

Hydrocortisone reduces the action of nystatin, and it reduces the activity of clotrimazole. Suppositories are chemically incompatible with hydrogen peroxide, potassium permanganate, salicylic acid and lactic acid, sodium bicarbonate.

Terms of sale

You can buy Nystatin without a prescription.

Storage conditions

Storage temperature for tablets is not higher than 25 ° C, for Suppositories and ointments not more than 50.

Shelf life

Tablets and Suppositories 2 years.
Ointment - 3 years.

Compatibility with alcohol

Instructions for use do not contain information on this matter. There is also no clear answer to the question of compatibility with alcohol. However, it is precisely known that alcohol causes an exacerbation of candidiasis, affecting the metabolism of carbohydrates. Alcohol-containing beverages can trigger the occurrence of adverse reactions. In this regard, its use is contraindicated in the treatment of the disease.

Nystatin in pregnancy

Pregnancy is a predisposing factor in the development of vulvovaginitis. The main thing in this situation is the safety of treatment. The instruction includes contraindications to the use of nystatin in pregnancy, since there is no information on their safety for the fetus. Suppositories Nystatin in pregnancy can be used only in exceptional cases, when the benefit to the mother exceeds the risk to the fetus. Feedback from visitors to the forums confirms that the drug in this form is sometimes prescribed to pregnant women for short courses of treatment.
Contraindicated in pregnancy, the use of ointment. However, it has been proved that the active ingredient is not excreted with milk when applied externally, so breastfeeding can be continued during ointment treatment. You can not apply the ointment on the area of ​​the breast and nipple.

Nystatin with thrush

Candidiasis of the mucous membranes of the genitals and the oral cavity is called thrush. The main method of treatment of oral and mild oral mammary is local treatment in the form of rinsing the mouth and treating the affected areas with a solution of this drug.
Women often have candidal vulvitis or vulvovaginitis. Vaginal cream or ointment is recommended for treatment of vulvitis, and tablets and suppositories are vaginitis. With an easy flow of vulvovaginitis, there is enough local treatment - vaginal tablets or suppositories: mycobag, clotrimazole, clion-D. Suppositories with nystatin from thrush recently rarely used, because most strains of the Candida fungus became insensitive to it. The drug has a mycostatic effect, and not mycicide. This gives temporary relief, improving well-being, but leads to a relapse. This is said and feedback from visitors to the forums.
If there is no other choice, or the woman has an individual intolerance to the above drugs, Nystatin is prescribed.
How to take Nystatin suppositories with thrush? They are injected deep into the vagina 2 times a day. It is very important that the sexual partner also treats with tableted antifungal drugs. If they are not treated, there is a possibility of re-infection of the woman. With a mild course of the disease, preparations for topical treatment can be replaced with a single dose of Fluconazole.
With recurrent candidiasis, which tends to aggravate more than 4 times a year, a combination of local and systemic prescription of drugs with one active substance is necessary. So, ointment and tablets are applied topically at a thrush inside. Possible and a treatment scheme: a candle with Nystatin 250000-500000 ED for 14 days, a thin layer of ointment on the vulvar and vaginal mucosa 2 times a day 14-21 days and tablets of 500,000 units 4 times a day for up to 10 days.
If there is a co-infection (yeast-like fungi and various bacteria), then complex drugs are used, which include nystatin: Macmiore, Terzhinan, Mikozhinax, Polizhinaks.

Reviews of Nystatin

Nystatin tablets, what are they from? It is an antifungal drug used to treat candidiasis - a fungal disease that can occur with skin, nail plate, mucous and internal organs (generalized candidiasis). Candidiasis of the mucous membranes of the genitals and the oral cavity is called thrush. The main method of treatment of oral and mastillitis of the oral cavity is local treatment. Adults can dissolve the tablet after meals 3-4 times a day or lubricate the affected areas of the oral mucosa with ointment. For newborns, a 250,000 ED tablet of nystatin is triturated and dissolved in a small amount of water. Drops of the resulting solution are applied to a gauze swab and treated areas 3-4 times a day. Children from 2 years can be given the drug inside 1/4 of the tablet three times a day, and treat the oral mucosa with the drug Candide.
Reviews of the Suppositories Nystatin with thrush are associated with side effects: frequent urination, irritation, burning in the vagina. Women often stopped treatment immediately after the disappearance of symptoms, while elimination of the pathogen did not occur and after a while the symptoms returned. According to many women, these Suppositories are not very effective, they believe that the drug is "obsolete" and give preference to modern antimycotic drugs. There are also reports that these Suppositories were prescribed during pregnancy to treat thrush.
Reviews about Nystatin in tablets are most often associated with the appointment of it for the purpose of preventing dysbacteriosis with prolonged use of antibiotics. From the first days of treatment with antibiotics, he was prescribed to many patients for 250,000 units 4 times a day. It is effective only for the prevention of intestinal candidiasis, since its systemic absorption is 3-5% and it does not affect fungi outside the intestine. When taking the tablets, side effects were noted in the form of nausea and upset of the stool. In order to prevent candidal infections in tablets containing antibiotic, this drug is immediately administered. So, tablets Tetracycline and nystatin are used for bronchitis, tonsillitis, furunculosis, tracheitis, cholecystitis, purulent infections of the skin and acne.
Nystatin ointment was used to treat superficial candidiasis of the skin and in the case of a mild course of the disease, good results were noted. In severe fungal skin lesions, one local application of ointment was not enough and systemic antimycotics (Fluconazole) were prescribed.