Beclazone 100mcg/dose 200doses

Instruction for Beclazone

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Composition

1, the aerosol dose contains 50, 100 or 250 μg of the active substance beclomethasone dipropionate. Excipients: hydrofluoroalkane and ethanol.

Form of issue

Aerosol is produced in aluminum cans equipped with a special dispensing valve and an inhalation device with a protective cap. Cylinders are designed for 200 doses and packed in cardboard packs.
In Beclazone Eco Light Breathing, balloons are found in a special aerosol inhaler that is activated with an active inhalation. In a pack of cardboard there is an optimizer and an inhaler with a balloon.

pharmachologic effect

Inhalation form of glucocorticosteroid has antiallergic and anti-inflammatory effect. The active component prevents the release of mediators responsible for the inflammatory process; oppresses the process of synthesizing prostaglandins, reduces the amount of arachidonic acid produced, enhances the production of lipomodulin.
Slowing down of granulation and infiltration is achieved due to inhibition of macrophages, a decrease in the production of lymphokines and inflammatory exudates. Against the background of treatment, it is possible to restore the patient's sensitivity to bronchodilators, which makes it possible to use them much less often.
The drug does not have a mineralocorticoid effect. The active ingredient relaxes the smooth muscle tissue of the bronchi, improving the performance of external respiration and reducing the hyperreactivity of the bronchial tree. Beclomethasone reduces edema of epithelial cells, reduces the production of mucus by bronchial glands, reduces the number of mast cells in the mucous membranes of the bronchi. Therapeutic doses of Beclazone Eco do not cause systemic reactions that are characteristic of most glucocorticosteroids.
Intranasal inhalation allows you to get rid of swelling and hyperemia of the mucous nasal cavity. The therapeutic effect is recorded on the 5th day of the course treatment.

Pharmacodynamics and pharmacokinetics

Part of a single dose that settles in the respiratory system after inhalation is absorbed by the pulmonary tissue, where the active substance is hydrolyzed sufficiently quickly to the form of monoproreonate. The latter is hydrolyzed to beclomethasone.
A small portion of the dose is ingested and swallowed, but is inactivated in the hepatic system after the first pass. In the liver, the drug is metabolized to polar metabolites. The active component is able to bind to plasma proteins by 87%.

Indications for use

Inhalation form of Beclomethasone is used in the main therapy of bronchial asthma, especially in the absence of the effect of treatment with sodium cromoglycate and / or bronchodilators. Medication is prescribed with hormone-dependent form of bronchial asthma.
Intranasal preparation is prescribed for vasomotor rhinitis, hay fever, rhinitis of allergic origin.

Contraindications

Intranasal and inhalational use is contraindicated when:
    Candidomycosis of the respiratory system;
    tuberculosis;
    severe attacks of bronchial asthma;
    pregnancy (I trimester);
    individual hypersensitivity to components.

Side effects

Respiratory tract:
    paradoxical bronchospasm;
    cough;
    hoarseness;
    eosinophilic pneumonia;
    irritation in the throat.
With intranasal application, candidiasis of the oral cavity or perforation of the nasal septum may develop. Allergic responses are possible:
    swelling of the lips, throat, face;
    erythema;
    hives;
    itching.
System responses are less frequently recorded:
    stunting (in pediatrics);
    osteoporosis;
    dysfunction of the adrenal cortex;
    glaucoma;
    cataract.
At registration of other negative reactions the consultation of the doctor and cancellation of preparation Beclazone is required.

Instructions for use (Method and dosage)

The average dose for inhalation is 400 μg / day. The number of inhalations per day is 2-4. The daily dose of beclomethasone can be increased to 1 g. Children are prescribed 50-100 μg each.
Instructions for use Beclazone Eco nasal: 1-4 times a day for 100 mcg.

Overdose

In acute overdose, dysfunction of the adrenal cortex is noted. In a few days, the normal work of the adrenal glands is restored independently, as evidenced by the level of cortisol.
Chronic overdose inhibits the work of the adrenal system, which requires monitoring of the reserve functions of the adrenal glands.

Interaction

Other glucocorticosteroids in combination with Beclazone additionally inhibit the adrenal system. Previous therapy with beta-adrenostimulyatorami in the form of inhalation can improve the effectiveness of the drug.

Storage conditions

Do not freeze. Keep cylinders away from sunlight. The preferred temperature is up to 30 degrees.
Shelf life - 3 years.

special instructions

Medication is not intended for relief (withdrawal of symptoms) of acute attacks. The attending physician should conduct explanatory discussions that reveal important aspects of the preventive use of inhalers for patients. The optimal therapeutic effect is achieved only with the regular and correct use of the medication.
In patients who used bronchodilators and did not achieve the desired results, improvement is recorded after 1 week of application of Beclazone.
When switching from oral forms of glucocorticosteroids to inhalation, one should be careful, since long-term therapy disrupts the adrenal system, and recovery is slow enough. A part of the patients with the abolition of steroids have general malaise, although the parameters of the function of external respiration are significantly increased. It is important to explain to patients that this is temporary discomfort, and to monitor the regularity of inhalation.

Reviews about Beclazone (opinion of doctors and patients)

The medication is widely prescribed by physicians-pulmonologists and allergists in the therapy of bronchial asthma. A practical form of release makes the drug convenient in daily use.
At thematic forums, patients leave their feedback on Beclazone Eco, indicating the high efficacy of the drug and good tolerability. Patients describe the convenience of using the line "Easy breathing", where inhalation is carried out by means of active inspiration. Reviews of Beclazone Eco Light breathing are only positive and do not raise doubts about the high quality of the drug.