Cyclo-Proginova tabs 0.5mg + 2mg + 2mg #21

Instruction for Cyclo-Proginova

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Composition

Cyclo-Proginova is a two-species dragee, in a single dragee of the first type (white) - 2 mg of estradiol valerate, in a second-colored pellet (light brown color) - 2 mg of estradiol valerate and 0.15 mg of norgestrel.
As additional ingredients that do not have a pharmacological effect, lactose monohydrate, corn starch, povidone 25,000 and 700,000, talcum, magnesium stearate, calcium carbonate, crystalline sucrose, macrogol 6000 and montan glycol wax are used.
In addition, additional constituents of light-brown pellets are: glycerol 85%, calcium precipitated carbonate, titanium dioxide, iron oxide, yellow and red, pigment.

Form of issue

The drug is produced in two kinds of pellets. In one package there are 11 pieces of white dragees and 10 pieces of light brown pellets in a blister, which has a calendar scale of 21 days.

pharmachologic effect

Counterimaging.

Pharmacodynamics and pharmacokinetics

The active substances Cyclo-Proginova can compensate for the inadequacy of the production of endogenous estrogens, lower the LDL cholesterol (class of low-density lipoproteins) in the blood.
The drug is effective for the relief of somatic, mental and other climacteric symptoms in premenopausal and postmenopausal periods, prevents a decrease in bone mass and osteoporosis.
As hormone replacement therapy (HRT) is able to reduce the risk of cardiovascular disease, and in combination with gestagens - prevents proliferative processes in the endometrium.

Indications for use

The drug Cyclo-Proginova is prescribed for estrogen deficiency (pre- and postmenopausal period, for ovariectomies due to non-malignant lesions, and also for radiation castration as hormone replacement therapy.
As a prophylaxis apply for osteoporosis in postmenopause, amenorrhea primary or secondary and dysfunction of the ovaries, as well as for the normalization of irregular menstrual cycles.

Contraindications

    hypersensitivity to any component of the drug;
    pregnancy and breastfeeding;
    bleeding from the vagina is not clear etymology;
    severe forms of liver function abnormalities, including Dabin-Johnson syndrome, Rotor syndrome, liver tumors, idiopathic jaundice, thromboembolic processes presently / in the presence of information in the anamnesis;
    herpes in the anamnesis;
    severe hypertriglyceridemia;
    thrombosis or thromboembolism;
    disorders of fat metabolism;
    diabetes with vascular complications;
    endometrial or breast cancer;
    sickle-cell anemia;
    deterioration of otosclerosis during the previous pregnancy.

Side effects

In some rare cases, Cyclo-Proginova caused the following side effects:
    headache;
    nausea;
    functional disorders of the stomach, indigestion;
    dizziness, anxiety, depressive symptoms, increased fatigue;
    changes in body weight;
    Chloasma, erythema nodosum;
    skin rash, itching and other allergic reactions;
    increased blood pressure;
    changes in libido;
    pathological engorgement of mammary glands;
    dysmenorrhea;
    uterine bleeding.

Instructions for Cyclo-Proginova (Method and dosage)

Dragee is taken orally - swallowed whole, with a small amount of water. If regular menstruation is observed, the drug is taken on the fifth day of the menstrual cycle (menstrual bleeding).
If amenorrhea is diagnosed, postmenopause or menstruation is very rare, then you can start any day, except for suspicion or an established pregnancy.
One package is designed for a 21-day course: every day take one dragee - the first 11 days of white, and the next 10 - light brown. Next, take a break for 7 days for the onset of menstrual bleeding as a result of drug withdrawal. After a break of 7 days, you should start a new packaging for a 21-day course.
Important! Instructions for use do not imply strict determination of the time of taking the drug, however, it is recommended to take the pills at about the same time of day. If the time of admission is missed, then the next dragee should be taken no later than 12-24 hours, otherwise - it may start vaginal bleeding.

Overdose

There is no information about the risk of serious side effects due to a random dose, many times greater than the daily dose, which has a therapeutic effect.
Symptoms characteristic of overdose: nausea, vomiting and vaginal bleeding.
There is no specific antidote, so treatment should be symptomatic.

Interaction

    Anticonvulsants and antimicrobials, with inducing action on liver enzymes, such as hydantoins, barbiturates, primidone, carbamazepine and rifampicin, oxcarbazepine, topiramate, felbamate, griseofulvin - can cause an increase in the clearance of sex hormones and a decrease in their clinical effectiveness.
    Some antibiotics (penicillin and tetracycline groups) - decrease in the level of estradiol.
    Substances that are largely conjugated. For example, Paracetamol - increased bioavailability of estradiol due to competitive inhibition of conjugation.

Storage conditions

In a place inaccessible to minors. At room temperature.
Shelf life - five years.

special instructions

The drug is not a contraceptive, therefore non-hormonal barrier methods should be used. If pregnancy is suspected, treatment is stopped immediately.
HRT affects glucose tolerance, which may alter the need for insulin or oral antibiotic drugs.

With alcohol

Excessive use of alcohol along with HRT may lead to an increase in the concentration of circulating estradiol.

In pregnancy and lactation

Hormone replacement therapy should not be administered during pregnancy or lactation. There is no confirmed information on teratogenic effects and the risk of congenital malformations in children who were given birth by women who took similar hormonal preparations prior to pregnancy, but the drug is not recommended for planning pregnancy.
It is established that in a small amount of sex hormones can be released together with the mother's milk.

Reviews of Cyclo-Proginova

Reviews about Cyclo-Proginova are different, the patients note the effectiveness in the normalization of the menstrual cycle and successful application as hormone replacement therapy. However, a lot of Internet users who take this hormonal remedy, report the development of such adverse reactions as swelling, bloating, breast tenderness.