Genferon 250000ME #10

Genferon instruction for use

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suppositories of genferon are a combined drug with immunomodulating action. They are used in the complex therapy of infectious and inflammatory pathology. Women also are used for local treatment of infectious and inflammatory diseases of the genital organs.

Form of issue and composition

suppositories of Genferon have a cylindrical bullet-shaped form. They contain several active substances, which include:
    Interferon alfa-2b human recombinant (rchifn-α-2b), which is contained in 3 doses of 250,000, 500,000 and 1,000,000 IU (international units).
    Taurine - 0.01 g.
    Benzocaine 0.055 g.
Also, the composition of the preparation includes auxiliary components - solid fat (to obtain a suppository with a mass of 1.65 g), macrogol 1500, dextran 60000, polysorbate 80, sodium hydrocitrate, emulsifier T2, citric acid, purified water. suppositoriesticks of Genferon are packaged in a planar cell pack of 5 pieces. The cardboard pack contains two contoured cell packs and instructions for use.

pharmachologic effect

The therapeutic effect of the drug is provided by a combination of active substances:
    Interferon alfa-2b human recombinant - is a powerful immunomodulator and immunostimulator. Has antiviral effect due to oppression of viral replication, antibacterial and antiproliferative action. Strengthens the functional activity of immunity.
    Taurine - also has an immunomodulatory effect, normalizes tissue metabolism, stimulates the regeneration (restoration) of damaged cells. Taurine also has powerful antioxidant properties, due to the binding and inactivation of free radicals (fragments of organic molecules that contain an unpaired electron in their composition).
    Benzocaine - a local anesthetic, reduces the sensitivity of nerve endings, reduces the severity of pain, the permeability of the cell walls in the area of ​​the inflammatory process.
When rectal (introduction into the lumen of the rectum), interferon is almost completely (bioavailability of about 80%) is absorbed into the systemic bloodstream and is included in the metabolism. With the introduction of the suppository intravaginally (in the vagina), the active substances are practically not absorbed into the systemic circulation and have a local therapeutic effect, accumulating in the mucous membrane of the female genital organs.

Indications for use

Use of suppositories Genferon is indicated for the complex treatment of infectious and inflammatory diseases, which include:
    Infections of the urogenital tract in women or girls - chlamydia, genital herpes, vaginal candidiasis, mycoplasmosis, ureaplasmosis, trichomoniasis, gardnerellez, erosion of the cervix or its inflammation (cervicitis), adnexitis, bartholinitis.
    Infectious and inflammatory pathology of the urogenital tract in men - balanitis, balanoposthitis, urethritis.
    Chronic inflammation of the bladder (chronic cystitis).
    Acute inflammatory process in the bronchial mucosa - acute bronchitis.
Such therapy allows to increase the functional activity of the immune system. Intravaginally, the drug can be used for pregnant and lactating women.

Contraindications for use

Absolute contraindication to the use of suppositories Genferon is an individual intolerance or hypersensitivity to the active substances or auxiliary components of the drug. With caution it is used in the aggravation of concomitant allergic pathology. Before starting the use of suppositories, Genferon must be convinced of the absence of contraindications.

Dosing and Administration

suppositories Genferon are used by their introduction into the rectum (rectal administration) or into the vagina in women (intravaginal administration). Dosage and treatment are determined by the main pathology:
    Infectious and inflammatory pathology of the urogenital tract in women - depending on the severity of the pathological process at 250,000 or 500,000 IU intravaginally 2 times a day. A combination of intravaginal (morning) and rectal (evening) administration of suppositories is also possible. The duration of therapy is on average 10 days.
    Infection-inflammatory pathology in men - suppositoriesticks Genferon are administered rectally (150,000 or 500,000 IU, depending on the severity of the pathological process) 2 times a day, 7-10 days.
    Complex therapy of acute bronchitis in adults - suppository 1,000,000 IU 2 times a day rectally, for 5 days.
    Chronic cystitis - with a relapse (exacerbation) of the inflammatory process 1000000 IU 2 times a day rectally. Then 1 candle (1,000,000 IU) is used every day for 40 days to prevent recurrence.
If necessary, the dosage and duration of the course of treatment can be corrected by the attending physician.

Side effects

In general, the drug is well tolerated. Sometimes local reactions are possible with intravaginal injection in the form of itching and burning in the vaginal area. With long-term use of high doses (more than 1,000,000 IU), the body develops general reactions - fever, a decrease in the number of leukocytes (leukopenia), muscle aches and joints, fatigue and decreased appetite. In such cases, the dosage is reduced or the drug is withdrawn.

special instructions

There are several specific indications regarding the use of genferon suppositories, which must be taken into account before starting their application:
    During the treatment of urogenital infection, it is necessary to carry out the same therapy with the sexual partner, in order to avoid re-infection.
    Women are allowed to use the drug during menstruation.
    The drug does not affect the speed of psychomotor reactions and concentration of attention.
In the chemist's network, the suppositories of Genferon are released on prescription. It is not recommended to use them independently or on the advice of third parties. In case of symptoms of side effects, it is necessary to consult your doctor who will decide whether to adjust the dosage or cancel the drug.

Overdose

Cases of drug overdose are not described. If the recommended therapeutic dose is exceeded, it is necessary to refrain from repeated use of suppositoriesticks for 24 hours.

Terms and conditions of storage

The shelf life of suppositories is 2 years from the date of manufacture. The drug should be stored in a dark place inaccessible to children at an air temperature of +2 to +8 ° C.