Immard tabs 200mg #30

Immard instruction for use

Reed more and buy Immard here

Composition

Each tablet contains an active ingredient: hydroxychloroquine.
Additional components: corn starch, talc, calcium hydrophosphate, macrogol, silicon dioxide colloidal, magnesium stearate, Polysorbate-80, titanium dioxide, gipromelloza.

Form release

Produced Immard in the form of tablets, coated. The medicine is packaged in blisters of 10 pieces, 6.3, 2 or 1 blister in a package.

Pharmacological action

The drug has anti-malarial effect.

Pharmacodynamics and pharmacokinetics

The use of this antimalarial drug helps suppress erythrocyte forms. When this occurs, the seal of lysosomal membranes and overlaps the release of lysosomal enzymes, impaired reduplication of DNA, RNA generation and disposal Нb eritrocitariani forms of Plasmodium.
For Immard also characterized by immunosuppressive and anti-inflammatory effect, contributing to the suppression of free radical processes, weakening the activity of proteolytic enzymes, chemotaxis of lymphocytes and leukocytes.
The drug exhibits variable absorption. Bioavailability is about 70%. Plasma protein binding is not more than 50%. The maximum concentration of the active substance is achieved within 2-3h. The drug accumulates in tissues and physiological fluids. Passes through the placental barrier and enters breast milk.
Metabolism occurs in the liver, resulting in formation of active metabolites dezetilirovanny. The drug is excreted from the body by the kidneys and liver. This process is quite slow and even when taking the tablets stops, the base material can be determined for some time in the urine.

Indications

Immard tablets are prescribed for malaria therapy:
exacerbations and suppressive treatment of diseases caused by Plasmodium vivax, Plasmodium malariae, Plasmodium ovale and Plasmodium falciparum strains;
malaria, which is caused by sensitive strains of Plasmodium falciparum;
rheumatoid arthritis;
red lupus-systemic and discoid;
photodermatitis's;
bronchial asthma;
gren.

Contraindications

Taking the drug is not recommended for:
hypersensitivity to it;
pregnancy, lactation;
children under 3 years of age.
Extreme caution is required in the treatment of patients with disorders of bone marrow hematopoiesis, diseases of the nervous and cardiovascular system, psychosis, porphyria, psoriasis, deficiency of glucose-6-phosphatdehydrogenase, renal or hepatic insufficiency.

Side effect

When taking Immard may have side effects that affect the musculoskeletal, nervous, cardiovascular and digestive systems. This can manifest such undesirable symptoms as weight loss, myopathy, neuromyopathy, myasthenia gravis, sensory disturbances, lowering of tendon reflexes, headaches, dizziness, psychosis, nervousness, emotional lability, convulsive state.
It is also possible the development of myocardiodystrophy, cardiomyopathy, atrioventricular block, decrease of myocardial contractility, myocardial hypertrophy, nausea, vomiting, decrease of appetite, abdominal pain, diarrhea.
There may be deviations in the work of the senses in the form of: tinnitus, hearing loss, visual acuity, photophobia, accommodation, swelling and opacity of the cornea, keratopathy, optic nerve atrophy, ciliary muscle dysfunction and so on.
Can occur disorders in the organs of hematopoiesis, which manifests itself: neutropenia, aplastic anemia, agranulocytosis, thrombocytopenia, hemolytic anemia.
Sometimes treatment is accompanied by undesirable manifestations such as skin rash, itching, alopecia, pigmentation disorders of the skin and mucous membranes, exacerbation of psoriasis and other.

Immard, usage instructions (Method and dosage)

The drug is taken orally at the same time with eating, drinking 200 ml of milk.
In the treatment of rheumatoid arthritis, the drug is prescribed in the initial daily dosage of 400-600 mg and a maintenance dose of 200-400 mg.
Juvenile arthritis therapy is carried out by the drug in a daily dose, which is calculated taking into account body weight, that is, 6.5 mg per kg of weight or an average of 400 mg.
For the treatment of discoid and systemic lupus erythematosus at the beginning of treatment daily dosage is set within 400-800 mg, maintaining a daily dose of 200-400 mg.
For the treatment of photodermatosis is assigned to a daily dose not exceeding 400 mg. during this period, it is important to limit exposure to sunlight on the skin of the patient.
When the treatment of malaria, patients are prescribed the drug in a daily dosage of 400 mg, which need to take every 7th day. For the treatment of children dose calculated by 6.5 mg per kg of weight, but not more than 400 mg.
With suppressing therapy, the drug is prescribed 14 days before exposure or immediately take a double dose of 800 mg for adult patients and 12.9 mg per kg of weight, but no more than 800 mg – for children. In the treatment of children, the daily dose is divided into 2 parts and taken with a 6-hour interval. The course of treatment is 8 weeks.
To stop an acute attack of malaria, Immard is prescribed in an initial dose of 800 mg for adult patients. After 6-8 hours, the patient needs to take 400 mg, and then 400 mg on the 2nd and 3rd day of therapy. It is also possible to take the drug once in an effective dosage of 800 mg.
For young patients, the total dose is prescribed at the rate of 32 mg per kg of weight, but not more than 2 g. the Drug is taken for 3 days: the first dosage is 12.9 mg per kg of weight, but no more than 800 mg, 2nd-6.5 mg per kg of weight, but no more than 400 mg – with 6 h interval, the 3rd dose is calculated similarly to the 2nd and taken at an interval of 18 h after it. The same calculation is used for the 4th dose, and the interval of its reception increases to 24 hours.

Overdose

In case of overdose with Immard, symptoms may appear, indicating the development of cardiotoxicity and neurotoxicity, as well as blood pressure, vision disorders, breathing and heart failure.
Particular danger of overdose poses to young patients. It is known that even the use of 1-2 g of the drug can cause death.
At the same time, treatment, including gastric lavage, activated charcoal is prescribed, forced diuresis with urine leaching and other symptomatic therapy is carried out. In addition, it is necessary to monitor the concentration of sodium in the serum and full medical control for 6 hours from the moment of relief of negative manifestations.

Interaction

If the drug is taken simultaneously with Digoxin, it can increase its concentration in plasma. When taken with aminoglycosides, there is an increase in the blocking effect on neuromuscular conductivity. Also, the action of hypoglycemic drugs, for which a decrease in dosing is required, increases.
When combined with antacids, it is important to observe the interval between receptions at least 4 hours.
Various alkalis and alkaline drink rapidly remove the drug from the body. Joint reception with penicillamine increases its plasma concentration and can lead to the development of side effects associated with the activity of the urinary system, hematopoietic organs and skin. It is possible the development of undesirable effects and when administered simultaneously with corticosteroids, salicylates, antiarrhythmic means class 1A, as well as hepato-, hemato -, and neurotoxic drugs.

Special instruction

Prior to the beginning of the therapeutic course, and in the time it requires to carry out ophthalmological examinations. In addition, it is necessary to control the cellular composition of blood and the state of skeletal muscles.
Patients engaged in driving transport and hazardous activities, should be careful, as taking the drug may affect the concentration, speed of psychomotor reactions and other functions of the body.

Terms of sale

You can buy Immard without a prescription.

Storage conditions

Place for storage tablets should be dark, dry, cool and inaccessible children.
Shelf life - 2 years.

Reviews of Immard

As the numerous reviews of patients about Immard show, the majority of patients with rheumatoid arthritis receive it together with hormonal preparations. At the same time, reports of side effects of this drug are rare. Interestingly, even without receiving the expected positive results (though such examples are enough), people do not complain about the drug.
There are also those who recognize it as the best medicine. For example, one lady said that for two years, receiving Prednisone and Immard she has forgotten some of his patients joints. She is very happy with the product and recommends everyone to take these pills.
Also, this drug, patients suffering from malaria, put on a par with those means that are well help to overcome the attacks of this disease. Only it should be taken immediately, as in such cases it is impossible to lose a minute. A week later, the pathogen can not be withdrawn by any drugs, because they will go into another stage of its development.
Despite the fact that the negative reviews about Immard are rare, they still present on some medical forums. So, patients report that after the second attempt of use of a medicine they had convulsions, unbearable pain in the head with the accompanying ringing in ears, an audition of facial muscles, the stomach got sick. And when the first course aggravated stomach ulcers and body rash.
To avoid anything like this, Immard should be used only strictly on the advice of a doctor and constantly monitor their condition, reporting all changes to the specialist.
When taking this drug, the role of planned medical examinations increases markedly, since it is toxic, which means that it is necessary to timely catch the moment when the degree of harmfulness of the drug exceeds its usefulness.