Alendronate tabs 70mg #4

Alendronate instruction for use

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Composition

In 1 tablet contains 70 mg of active substance alendronic acid, as well as auxiliary components: microcrystalline cellulose, silicon dioxide, croscarmellose sodium, magnesium stearate.

Form of issue

Alendronate is available in tablet form.

pharmachologic effect

Inhibitor of bone resorption.

Pharmacodynamics and pharmacokinetics

The active component is alendronic acid.
The drug is a specific non-hormonal inhibitor of bone osteoclastic resorption.
The principle of the effect of the drug is based on inhibiting the activity of osteoclasts.
The basic substance belongs to the class of aminobisphosphonates and is an analog of pyrophosphate, under the action of which there is binding of hydroxyapatite in bone tissue.
Alendronate helps to restore and form healthy bone tissue with a natural histological structure.
The drug regulates phosphorus-calcium metabolism, increases the bone mineral density, strengthens the process of osteogenesis, helps restore a positive balance between bone repair and resorption.

Indications for use

Alendronate is prescribed for osteoporosis in men, with Paget's disease, with osteoporosis amid prolonged therapy with glucocorticosteroids.
The drug is prescribed to women during the postmenopausal period in order to prevent fractures of the spine, hip and other bones.

Contraindications

Alendronate is not used for hypocalcemia, intolerance to the main substance of alendronic acid, in pregnancy, in chronic renal failure, in breastfeeding, if it is impossible and unable to stand on its own in an upright position or sit for 30 minutes.
Instructions for use Alendronate does not contain information on the efficacy and safety of the medicinal product for children.

Side effects

There are the following side effects from the senses: episcleritis, scleritis, uveitis.
From the side of the central nervous system: migraine, severe headaches.
From the musculoskeletal system: osteonecrosis of the lower jaw, muscle cramps, arthralgia, myalgia, ossalgia.
On the part of the digestive system: dysphagia, diarrhea, constipation, nausea, acidic eructation, dyspepsia, epigastric pain, esophagitis, gastritis, ulceration of the intestinal mucosa wall, melena, erosion of the esophagus, perforation of the ulcer against the peptic ulcer, ulceration of the oropharynx, bleeding from the upper parts of the digestive system.
Possible allergic response in the form of influenza-like syndrome, rash, erythema, pruritus, angioedema, urticaria, toxic epidermal necrolysis, Stevens-Johnson syndrome, photosensitization.

Alendronate, instructions for use (Method and dosage)

Alendronate is prescribed 1 time per day for 2 hours before meals, the pill should be washed with plain water without chewing.
For the prevention of osteoporosis appoint 5 mg per day, with osteoporosis in the postmenopausal period, the dose is increased to 10 mg.
With Paget's disease, the drug is taken for 6 months at 40 mg per day. Tablets in the envelope prescribed 70 mg, once a week.

Overdose

It is manifested by hypocalcemia, hypophosphatemia, diarrhea, gastritis, ulcerative lesions of the stomach and intestines.
Treatment is recommended for symptoms, and milk and antacids should also be taken.

Interaction

With the simultaneous administration of antacids, calcium preparations, there is a decrease in absorption.
The recommended interval between Alendronate and other medications should be at least 1 hour because of the risk of increased severity of side effects.

Storage conditions

In a place inaccessible to children at a temperature of no more than 25 degrees Celsius.
Shelf life - three years.

special instructions

Tablets should be drunk only with ordinary water, because juices, tea, coffee, mineral water and other drinks adversely affect the absorption of the drug.
Taking the medication immediately after the morning rise allows you to reduce the irritant effect of the drug on the walls of the esophagus.
After taking the pill is not recommended to take a horizontal position for half an hour because of the risk of esophagitis. Before starting treatment, correction of hypocalcemia is required.
Therapy should start with a diet rich in calcium salts.