Artrocare caps 50mg #100

Artrocare instruction

You can buy Artrocare here

Composition

In 1 capsule of diacerein 50 mg.
Lactose monohydrate, croscarmellose sodium, magnesium stearate, sodium lauryl sulfate, povidone, silicon dioxide, - as auxiliary substances.

Form of issue

Capsules 50 mg No. 30 or No. 100.

pharmachologic effect

Anti-inflammatory, chondroprotective.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Diacerein (anthraquinone derivative) does not belong to non-steroidal anti-inflammatory drugs. It inhibits the synthesis of inflammatory mediators -interleukins 1, 6 and tumor necrosis factor TNF-α, which play a role in the inflammatory process, degradation and destruction of cartilaginous tissue.
Diacerein slows down the production of metal-proteinases, which are associated with the degeneration of cartilaginous tissue. With prolonged intake stimulates the synthesis of glycosaminoglycans, proteoglycans and hyaluronic acid.
Has chondroprotective and anti-inflammatory effect, reduces pain syndrome and when it is taken, the need for NSAIDs gradually decreases.

Pharmacokinetics

When ingested quickly absorbed from the digestive tract. Deacetylation turns into rhein.
Eating increases bioavailability by about 25%. Cmax in the blood is determined after 2-3 hours. T1 / 2 - 255 min. 100% binding of rhein to albumin is noted. With multiple admission, Cmax increases, since cumulation of the drug is noted. Penetrates through the BBB and the placenta. It is excreted by the kidneys.

Indications for use

    primary osteoarthritis;
    secondary osteoarthritis.

Contraindications

    increased sensitivity to anthraquinones (laxatives - senna, buckthorn, rhubarb);
    intestinal obstruction;
    inflammation of the intestine;
    severe hepatic or renal insufficiency;
    lactose intolerance;
    pregnancy;
    lactation;
    age to 18 years;
    deficiency of lactase.
With caution should be used with a tendency to diarrhea and impaired renal function.

Side effects

An Artrocare can cause:
    rash, itching;
    urticaria;
    anaphylactic shock;
    bronchospasm;
    angioedema;
    vomiting, bouts of nausea, abdominal pain, diarrhea.
Thus the dose decreases - 1 capsule in day.
Intensive staining of urine (up to brown color) does not require cancellation or reduction of the dose of the drug.

Instructions for use Artrocare (Method and dosage)

Capsules are taken orally, whole, after a meal with a sufficient amount of liquid. The usual dosage is 1 capsule (50 mg) 2 times a day. Clinical effect is observed after 3-4 weeks. In the first 2 weeks of relaxation chair can be observed, in connection with which begin treatment with 1 capsule (50 mg) per day and after 4 weeks the dose was increased to 2 capsules (100 mg). The drug can be taken continuously for a long time or courses for at least 4 months.
Before the onset of the effect in severe pain, the drug can be taken with analgesics.
The instruction for the use of the Artrocare contains a warning that during the treatment it is necessary to monitor the blood, urine and hepatic transaminase activity. If the kidney function worsens, the dose of the drug decreases, or the question of its cancellation is resolved.

Overdose

Overdose is manifested by symptoms: diarrhea, asthenic conditions. Treatment is symptomatic.

Interaction

It is not recommended to take simultaneously with laxatives or with products that accelerate the emptying of the intestines (vegetables, fiber, jaoster). This can cause or exacerbate side effects from the intestine.
When taken with antibiotics that affect the intestinal microflora, or chemotherapeutic agents, the incidence of side effects on the part of the intestine also increases.
Antacids based on aluminum and magnesium hydroxide reduce absorption and reduce the bioavailability of diacerein.

Storage conditions

At a temperature of no more than 25-30 ° C.
Shelf life - 3 years.

Reviews about Artrocare

The Artrocare refers to symptomatic drugs of delayed action, which are used for joint pain. They also include glycosamine sulfate, chondroitin sulfate, hyaluronic acid preparations, Alflutop. Compared with NSAIDs, these drugs have a slower clinical effect, but it persists long after treatment. Its action is aimed at slowing the progression of osteoarthritis, stabilizing the changes in hyaline cartilage. As the intake decreases, the need for anesthetics decreases and the function of the joints improves.
Studies have shown that the effectiveness of diacerin is more pronounced in osteoarthrosis of the hip joint. The slowing down of the process of constriction of the joint gap after long-term therapy with diacerein - 3 years is demonstrated.
Reviews of the Artrocare on the forums show this.
"I began to take an Artrocare. I am treated with breaks, I noticed relief in a month or a year and a half. At the very beginning of the reception his intestines ached "
"I drank courses for 6 months. At the time of taking the pain was not, in between appointments appeared, but were not as strong as before "
"Cleans aching pain with osteoarthritis, I have the first stage"
"It helps me, my joints and spine ached, I drink Artrocare the second month. After this drug, the pain is diminished "
"Everything normalized after taking the drug, and the hip joint hurt"
"I take an Artrocare for 10 days. There are no side effects "
However, there are negative reviews, which are associated with the slow development of the drug and the presence of adverse reactions in the form of diarrhea. In this regard, very few patients who have conducted treatment courses for many years. It should be taken into account that the effectiveness depends on the severity of the disease and the degree of disruption of the joint function.