Diaflex caps 50mg #30

Diaflex instruction for use

You can buy Diaflex on this page

Release form and composition

The drug Diaflex is available in capsule dosage form for oral administration (by mouth). They are yellow with a brown tint color, hard shell, inside the capsule contains white powder. The main active ingredient of the drug is diacerein, its content in one capsule is 50 mg. It also includes auxiliary components, which include:
    Magnesium stearate.
    Lactose monohydrate.
    Gelatin food.
    Iron oxide (II) as a dye.
    Titanium dioxide.
Capsules are packaged in a blister pack in the amount of 10 pieces. The carton pack contains 3 blister packs (30 capsules) and instructions for use of the drug.

pharmachologic effect

The main active ingredient of capsules Diaflex diacerein is metabolized in the human body to the active compound Rein. It inhibits (inhibits) the synthesis of interleukin-1 and other inflammatory mediators (tumor necrosis factor, cytokines, prostaglandins), which cause the development of pain due to direct stimulation of nerve endings, soft tissue swelling and hyperemia (increased blood filling of tissues in the inflammatory process). Also interleukin-1 plays an important role in the process of degradation (destruction) of cartilage tissue. The therapeutic effect does not develop immediately, but after 2 weeks from the start of the drug entering the area of ​​the inflammatory process, first of all it concerns the slowing down of the degradation processes of the cartilage of the joints.
After taking the capsule diaflex, the active substance is absorbed into the systemic circulation from the lumen of the small intestine. It is well distributed in all tissues of the body with a predominant accumulation in the structures of the musculoskeletal system and connective tissue. Diacerein and rein are metabolized in the liver, decomposition products are mainly excreted by the kidneys in the urine. The half-life (time during which 50% of the entire dose is eliminated) is about 4 hours.

Indications for use

The use of capsules Diaflex is shown in the degenerative-dystrophic pathology of the cartilage tissue of various joints with the development of the inflammatory process. In particular, for the treatment of osteoarthritis and osteochondrosis, both of the primary and secondary course of the pathological process.

Contraindications for Diaflex

The use of capsules Diaflex is contraindicated in certain conditions of the human body (physiological and pathological), which include:
    Hypersensitivity to the active substance of the drug, its auxiliary components or their individual intolerance.
    Individual hypersensitivity to anthraquinone laxative drugs.
    Children age under 18 years.
    Lactose intolerance (this carbohydrate is an auxiliary component of the capsules Diaflex) - lactase deficiency, glucose-galactose malabsorption, congenital intolerance to some carbohydrates.
With caution, the drug is used in patients with hepatic or renal failure, inflammatory bowel disease and its obstruction.

Dosage and administration

Diaflex capsules are taken inside entirely, without chewing and washing down with enough water. To increase the bioavailability and better absorption of the active substance into the blood from the intestine, it is recommended to take the drug after a meal. The average dosage is 50 mg (1 capsule) 2 times a day at regular intervals (preferably after 12 hours). The course of therapy is determined individually, its average duration is 3-4 months. If necessary, during the year, the course of treatment with capsules of Diaflex can be repeated several times. The first few days is recommended to take 1 capsule per day (in the evening after dinner), then increase the dose to the average therapeutic.

Side effects of Diaflex

After taking diaflex capsules, adverse reactions from the digestive system can develop in the form of nausea, vomiting, abdominal pain and diarrhea. It is also possible the development of toxic hepatitis - inflammation of the liver due to damage to its cells. There may be allergic reactions in the form of a rash and itching of the skin, urticaria (a characteristic rash with swelling of the skin, reminiscent of a stinging nettle). Less common is the development of severe sensitization reactions, which are characterized by angioedema of the angioedema (pronounced swelling of soft tissues with predominant localization in the face and external genital organs), bronchospasm (narrowing of the bronchi with the development of shortness of breath) or anaphylactic shock (progressive arterial hypotension and multiple organ failure).

special instructions

Before you start taking the drug, you must carefully read the instructions to it. There are several specific indications regarding the use of Diaflex capsules, which include:
    Joint administration with drugs containing aluminum or magnesium hydroxide (antacid preparations) significantly reduces the bioavailability of the active ingredient of the capsules Diaflex.
    With the joint use of capsules diaflex and antibiotics increases the likelihood of side effects from the intestine.
    Parallel intake of laxative drugs is excluded.
    Taking the drug is contraindicated in pregnancy and breastfeeding. If necessary, its use for lactating women, the child for the period of treatment is transferred to artificial adapted milk formulas.
    Diaflex capsules do not affect the speed of psychomotor reactions and the ability to concentrate.
Pharmacies capsules Diaflex available on prescription. It is not recommended to use them alone or on the advice of third parties.

Overdose

If the recommended therapeutic dose is exceeded, nausea, vomiting and abdominal pain develop. In this case, the stomach, intestines, intestinal sorbents are taken and symptomatic therapy is taken.

Terms and conditions of storage

The shelf life of capsules Diaflex is 5 years from the date of their manufacture. The drug should be stored in a dark, dry place at an air temperature not higher than + 25 ° C. Keep away from children.

Terms of sell

To buy Diaflex the prescription is not required.