Niselat tabs 600mg #20

Instruction for Niselat

You can buy Niselat online

Composition

In one tablet of the drug contains ammonthmethine guacyl 600 mg (active substance).
Excipients: lactose monohydrate, hypromellose, colloidal silicon dioxide, sodium carboxymethyl starch, magnesium stearate.
Composition of the film membrane: hypromellose, titanium dioxide, macrogol 400.

Form of issue

Niselat is a tablet coated with a white color, in the form of a capsule, with a specific odor. 10 such tablets - in a blister, two such blisters - in a cardboard bundle.

pharmachologic effect

Has analgesic, anti-inflammatory, desensitizing, antipyretic, gastroprotective action.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics amtolmethine guacyl
A non-steroidal anti-inflammatory agent, an indiscriminate cyclooxygenase blocker, a precursor of tolmetine in the metabolic chain. Suppresses the adhesion of platelets; blocks the cyclooxygenase of the first and second types, alters the metabolism of arachidonic acid, reduces the synthesis of prostaglandins, inhibits the exudative and proliferative phases of the inflammatory process. Worsens the permeability of capillaries; normalizes lysosomal membranes; slows down biosynthesis or inactivates mediators of inflammation (histamine, prostaglandins, bradykinins, complement factors, cytokines).
It blocks the reaction of bradykinin with tissue receptors, reduces pain in the focus of inflammation. Affects the thalamic centers responsible for pain sensitivity; reduces the content of biogenic amines exhibiting algogenic properties. Eliminates the intensity of pain syndrome, reduces morning stiffness, increases the amplitude of movements in the joints four days from the start of treatment. The protective action of amtolmethine guacyl on the gastric mucosa is found by activating the capsaicin receptors in the walls of the digestive tract. This is accompanied by an increase in the synthesis of nitric oxide and creates a counterbalance to the negative effect of cyclooxygenase inhibition.

Pharmacokinetics

Suction after admission is usually rapid and complete. The drug accumulates in the walls of the digestive tract, where its high concentration is maintained for 2 hours. Metabolized by hydrolysis with esterases of blood with the formation of the following metabolites: MED5, guaiacol and tolmetine, turning into tolmetine (active metabolite), which has a pharmacological effect in the tissues. It binds to plasma proteins by 99%. The half-life is 5 hours. In a day the drug is completely excreted in the urine (80%) and with bile (20%).

Indications for use

    osteoarthritis;
    rheumatoid arthritis;
    ankylosing spondylitis;
    bursitis;
    articular syndrome with gout;
    tenosynovitis;
    arthralgia;
    pain syndrome;
    myalgia;
    migraine;
    neuralgia;
    headache and toothache;
    algodismenorea;
    pain with burns and injuries.

Contraindications

    Allergy to tolmetine, amtolmethine.
    Presence of bronchial asthma, allergies to Aspirin or recurrent polyposis.
    Ulcerative lesions of gastric mucosa and duodenum.
    Gastrointestinal bleeding in the active phase.
    Cerebrovascular bleeding.
    Violation of blood clotting.
    Diseases of the inflammatory bowel (ulcerative colitis, Crohn's disease) in the phase of exacerbation.
    Heart failure in the stage of decompensation.
    Severe liver and kidney damage.
    Arterial hypertension.
    Postoperative period of aortocoronary shunting.
    Lactose intolerance, lactase deficiency, glucose-galactose malabsorption.
    Pregnancy and lactation.
    Age is less than 18 years.

Use with caution when:

    hyperbilirubinemia;
    ischemic heart disease;
    chronic heart failure;
    cerebrovascular diseases;
    diabetes mellitus;
    lesions of peripheral arteries;
    chronic renal failure;
    in old age.

Side effects

    On the part of the digestive system: nausea, dyspepsia, diarrhea, vomiting, constipation, peptic ulcer.
    From the genitourinary system: infection of the urinary tract.
    From sight and hearing: visual impairment, tinnitus.
    On the part of the respiratory system: bronchospasm, rhinitis, shortness of breath, laryngeal edema.
    From the nervous system: dizziness, drowsiness, depression.
    On the part of the circulatory system: rising pressure.
    On the part of the hematopoiesis system: anemia, thrombocytopenia, leukopenia.
    From the skin: rash, purpura, dermatitis, urticaria, Lyell's syndrome.
    Allergic reactions: anaphylactoid reactions.

Instruction for Niselat

Instructions for use Niselat prescribes to take 600 mg of the drug 2 times a day. To maintain gastroprotective action, the drug should be used on an empty stomach. The maximum daily dose is 1800 mg.

Overdose

Symptoms: nausea, abdominal pain, vomiting, metabolic acidosis. Treatment: to make a lavage of the stomach, take activated charcoal, conduct symptomatic therapy.

Interaction

The drug lowers the effectiveness of antihypertensive, uricosuric drugs and diuretics.
Niselat enhances the effect of antiplatelet agents, fibrinolytics, anticoagulants, side effects of estrogens, mineralocorticoids.
Kolestyramin and antacids reduce the absorption of Niselat.
Myelotoxic agents increase the hematotoxic properties of the drug.

Storage conditions

Keep away from children. Store at a temperature of up to 25 degrees in a dry, dark place.
Shelf life - two years.

special instructions

Treatment with the drug should be canceled 48 hours before the analysis for 17-ketosteroids. During therapy, it is recommended to refrain from engaging in dangerous activities that require attention and speed of reaction.

Children

The drug is contraindicated in persons under the age of 18 years.

In pregnancy and lactation

The drug is contraindicated for use during pregnancy and lactation.

Reviews of Niselat

In general, the reviews about Niselat leave a positive mark, both in terms of therapeutic effectiveness, and in relation to the low frequency of side effects.