Phlogenzym tabs #100

Phlogenzym user manual

You can buy Phlogenzym here

Composition

One tablet of Phlogenzym contains 450 units. bromelain, 1440 units. trypsin and 100 mg of rutin.
Also, the composition includes a number of auxiliary inactive substances: lactose monohydrate, corn starch, magnesium stearate and stearic acid, distilled water, colloidal silicon dioxide, talc.
The composition of the shell include: methacrylic acid and methyl methacrylate copolymer, macrogol, talc, triethyl citrate, and vanillin.

Form of issue

The drug is produced in biconvex round tablets coated with a smooth shell of greenish-yellow color with acceptable deviations of homogeneity of color - marbling or the presence of point inclusions. Inside the tablet is a light yellow color, has a tuberous structure. Tablets have a characteristic odor.
Tablets are packed in blisters for 20 pcs. or in a vial containing 800 tablets. In one carton can be 2.5.10 blisters or 1 bottle.

pharmachologic effect

Immunomodulating, anti-inflammatory.

Pharmacodynamics and pharmacokinetics

Phlogenzym consists of highly active proteolytic enzymes of plant, as well as animal origin. Their combination gives a multiple pharmacological effect on pathophysiological, biochemical processes, rendering:
    anti-inflammatory;
    immunomodulating;
    antiplatelet;
    fibrinolytic;
    thrombolytic;
    decongestant;
    secondary analgesic effect.
By optimizing the inflammatory process: a decrease in oncotic pressure and pressure on the nerve endings, edema of tissues, elimination of ischemia and restoration of microcirculation, direct proteolysis of mediators of inflammation - in a complex gives a secondary analgesic effect.
Improve blood supply, viscosity properties of bronchial secretion, function of ciliated epithelium, restoration of drainage function of bronchi, dilution of sputum - facilitates breathing and has antitussive effect for smoking and chronic diseases of the respiratory tract.

Pharmacokinetics

Transit passage through the upper gastrointestinal tract, does not cause injury. Absorption occurs in the small intestine along the pathway of resorption of molecules - endocytosis and pinocytosis. The active substances - proteases bind to transport proteins - α-2-macroglobulin and α-1-antitrypsin, which leads to the formation of a reversible protease-antiprotease complex that is capable of:
    prevent allergic reactions (due to the masked antigenic determinants of exogenous proteases);
    move proteolytic enzymes along the vascular system to the site of inflammation or to localize trauma;
    to retain and slow the excretion of proteolytic enzymes, thereby increasing the circulation time and prolonging the therapeutic effect.
Together with the enzymes, the active form of the antiprotease is able to perform the functions of the extracellular regulator of pro-inflammatory cytokines and growth factors - through their transfer, clearance and elimination.
Proteolytic enzymes, falling into the focus of inflammation or into the wound, hydrolyse damaged protein molecules and remove cellular detrites, which helps to clean and heal wounds. In addition, they:
    accelerate the process of decay of inflammatory mediators;
    increase the activity of killer cells and phagocytes;
    lower the level of transforming β-growth factor, which can cause excessive scarring;
    regulate the formation of basal membranes (glycoprotein - laminin);
    reduce the risk of thrombus formation and participate in the lysis of existing blood clots;
    decrease in the level of atherogenic lipids, contributes to the increase in HDL, which reduces the risk of vascular disorders and atherosclerosis;
    prevent the development of metabolic disorders and purulent complications, for example, in the case of prolonged immobilization;
    normalize the permeability of the walls of blood vessels, microcirculation and trophic processes;
    regulate the level of immunoglobulins and antibodies in the blood;
    stimulate the immunomodulating antiviral factor - interferonogenesis.
The unabsorbed routine and hydrolase are excreted with feces. The resorbed enzymes are excreted through the cells of the mononuclear-phagocytic system.

Indications for use

As part of complex therapy and for the prevention of such diseases and conditions as:
    postoperative period and rehabilitation for improvement of repair and regeneration;
    with purulent-inflammatory complications;
    prevention of adhesions and keloid formation;
    fractures and injuries of bones, ligaments, as well as bruises, bruises, injuries as a result of sports and loads, burns, improved endoprosthetics and osteosynthesis;
    with acute deep vein thrombosis, thrombophlebitis of superficial veins, postthrombotic disease, obliterating atherosclerosis, chronic angiopathy, microcirculatory disorders, edema and lymphedema;
    acute and chronic inflammatory processes of the genito-urinary tract, including cystitis, urethritis, cystopyelitis and prostatitis; organs of the small pelvis - adnexitis, salpingoophoritis;
    with vascular complications of climacteric period, reduction of complications of USG (hormone replacement therapy);
    IHD, prevention of angina attacks and recurrent myocardial infarction;
    with hepatitis;
    with rheumatoid and reactive arthritis, ankylosing spondylitis, rheumatic soft tissue lesions;
    with multiple sclerosis;
    with pneumonia or chronic obstructive pulmonary disease.

Contraindications

    hypersensitivity to the components of the drug;
    congenital or acquired disorders of the system or individual coagulation factors;
    marked violations of the liver, kidneys;
    the age category is children.
With caution apply this combination drug for hemodialysis, lactose intolerance, pregnancy and lactation - it is recommended to consult with your doctor.

Side effects

    allergic reactions in the form of skin rashes, itching;
    increased frequency, change in consistency and odor of the stool, which quickly stop when the dosage is temporarily reduced;
    nausea, swelling and abdominal pain, headaches, dizziness, exanthema, general weakness, a feeling of fullness of the intestine.
Side effects are most often transient, so they go after reducing the dose or canceling the drug.

Instruction for the application of Phlogenzym (Method and dosage)

Tablets are taken half an hour before meals. It is necessary to drink a glass of water, do not chew!
Adults in the complex therapy should take 3 tablets 3 times a day. The course of treatment is 2 weeks. Instruction for the use of Phlogenzym in the prevention of taking 2 tablets 3 times a day for 2 weeks.
The change in dose or duration should be determined by an individually qualified specialist.

Overdose

Cases of overdose had not previously been established.

Interaction

    With antibiotics - potentiation of antibiotic therapy.
    With hormones - reduced risk of thrombosis.

Storage conditions

In a dry dark place, the temperature is within 15-25 ° Celsius. It is recommended that you completely restrict access to children.
Shelf life not more than three years.

Reviews about Phlogenzym

Reviews about Phlogenzym are positive, it is used for various conditions and diseases, since it has multiple effects. The effectiveness of the drug is confirmed by patients who took Phlogenzym after sports injuries, after surgical intervention in dentistry, inflammatory processes of the genitourinary system, when removing adhesions, etc. Among the shortcomings is the price.