Desloratadine tabs 5mg #10
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Instruction for DesloratadineReed more and buy Desloratadine onlineCompositionIn 1 tablet of desloratadine 5 mg.Cellulose microcrystalline, magnesium oxide, starch, lactose, hypromellose, zinc stearate as auxiliary substances.Form..
Instruction for Desloratadine
Reed more and buy Desloratadine online
In 1 tablet of desloratadine 5 mg.
Cellulose microcrystalline, magnesium oxide, starch, lactose, hypromellose, zinc stearate as auxiliary substances.
Form of issue
Tablets in a film coat of 5 mg.
Pharmacodynamics and pharmacokinetics
Desloratadine is a blocker of H1-histamine receptors, which has a long-term effect. It is an active metabolite of Loratadin, which is 2-4 times stronger than its effect. Inhibits a number of reactions of allergic inflammation: the release of cytokines, interleukins, chemokines, mediated release of prostaglandin D2.
It alleviates the course of allergic reactions, has antipruritic and anti-edematous action, reduces hyperreactivity of the bronchi, eliminates spasm of smooth muscles, reduces the severity of allergen-dependent bronchospasm. The action of the drug taken inside, continues for 24 hours.
Has no effect on the central nervous system, even at a dose of 7.5 mg: does not have a sedative effect, does not affect the speed of psychomotor reactions. There is no cardiotoxic effect.
It is well absorbed from the digestive tract, the minimum concentration is found in the blood in half an hour, and the maximum - after 3 hours. 87% is associated with blood proteins. At a dose of 20 mg, taken within 2 weeks, there is no sign of cumulation. Eating does not affect the distribution of the drug.
Intensively metabolized. It is excreted from the body by calves and kidneys. Half-life is 20-30 hours.
Indications for use
chronic course of urticaria;
year-round allergic rhinitis.
Desloratadine is not used when:
hypersensitivity to it;
age under 12 years;
impaired absorption of glucose-galactose;
rash, urticaria, angioedema;
headache, dizziness, insomnia, convulsions, hallucinations;
dry mouth, abdominal pain, nausea, diarrhea, increased bilirubin levels;
Instructions for use Desloratadine (Method and dosage)
It is taken orally, preferably at the same time. The intake of the drug is not dependent on food intake. The tablet is swallowed whole. Adults and children over 12 years of age are prescribed 5 mg once a day. Desloratadine Teva is used in the same dosage and with the same multiplicity of intake for adults and children.
Duration of admission depends on the course of the disease and the frequency of manifestations of allergy symptoms. With intermittent rhinitis, allergy symptoms are observed less than 4 weeks per year, and the drug treatment is completed by the disappearance of symptoms and resumed upon their re-emergence. With persistent rhinitis, allergy symptoms occur more than 4 weeks per year and are associated with a permanent contact with the allergen. In this case, the treatment is continued until the contact with the allergen has ended.
The daily intake of the drug at 20 mg 2 weeks was not accompanied by changes in the CAS. Admission to a dose of 45 mg 10 days (for clinical studies) did not cause prolongation of the QT interval and any significant adverse reactions.
Interaction with other drugs, which would be of clinical importance, was not identified. Does not enhance the action of ethanol.
Terms of sale
To buy Desloratadine you don't need a prescription.
At a temperature of no more than 25 degrees Celsius.
Shelf life - 3 years.
Reviews about Desloratadine
Desloratadine is one of the most modern antihistamines (III generation). The active metabolite of Loratadin, which is three times more active than it.
Positive reviews about Desloratadine Teva are explained by high efficiency in the treatment of allergic diseases. This drug has a decongestive effect - it eliminates nasal congestion with seasonal allergic rhinitis. This effect is not observed in other modern H1-antagonists. The drug is effective in cases of combination of rhinitis with atopic bronchial asthma. In patients with chronic urticaria, the drug had a pronounced effect, which was expressed in the rapid relief of the symptoms of the disease.
All patients note the convenience in use - once a day, while not reducing the effectiveness. Accepted him note that the drug does not have a sedative effect, a negative effect on the heart and does not cause psychomotor disorders.