Emoxipine drops 1% 5ml

Reed instruction and buy Emoxipine here

Composition

One ampule contains 1 milliliter of a solution that contains 2-ethyl-6-methyl-3-hydroxypyridine hydrochloride (emoxipine) 0.01 g. Ampoules are used to administer the intramuscular or intravenous emoxipine.
Emoxipine 1, which is used in ophthalmology, has a similar composition of the active substance, but it differs only in the form of release: ampoules are replaced with more convenient bottles with dispensers at the end, which allows to measure exactly one drop of the substance for each eye.

Form of issue

The drug is released in ampoules with different dosages. Each pack of Emoxipine contains five ampoules with the indicated dosage on the package.
Drops for eyes are let out by a vial in 5 ml with a pipette.

pharmachologic effect

Emoxipine (INN - Emoxipine) is an angioprotector that reduces the level of vascular wall permeability through the acceleration of free radical processes, and the drug is an antioxidant and antihypoxant. Emoxipine will reduce the level of blood viscosity, the permeability of the vascular walls and the tendency to develop hemorrhages. In addition, the active substances of the drug will increase the level of cyclic nucleotides in the brain tissue and blood platelets.
Fibrinolytic activity of the drug is manifested in the fact that in the case of an acute period of infarction, the device is able to expand the coronary vessels, thereby limiting the developing focus of necrosis. Also, the conduction and contractility of the heart will be improved.
As an ophthalmic substance, emoxipine has retinoprotective properties, it protects the retina from the action of high-intensity light rays. Drops of Emoxipine will help resolve intraocular hemorrhages and improve the process of microcirculation in the eye.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Positive effect on blood clotting: by reducing the overall coagulation index and reducing the process of platelet aggregation, the drug lengthens the time of blood coagulation. Membranes of cells and vessels under the action of the drug stabilize, red blood cells increase their resistance to hemolysis and potential mechanical injuries.
Effective inhibition of free radical oxidation of lipids contained in biomembranes. Increase in the activity of enzymes responsible for the antioxidant function. It is able to exert a hypolipidemic effect by reducing the synthesis of triglycerides.
The use of Emoxipine is able to reduce the manifestations of cerebral hemodysfunction. Has a positive effect on the stability of the cerebral cortex to ischemia and hypoxia. Corrects autonomic dysfunction in cases of cerebral circulation disorders.
Emoxipine has a pronounced cardioprotective effect. The cardiovascular system will be protected in case of ischemic myocardial damage: the drug blocks its spread, also expanding the coronary vessels.
As eye drops, Emoxipine protects the retina from potential damage due to exposure to high-intensity light rays. In addition, due to the drug, resorption of hemorrhages within the eye is possible.

Pharmacokinetics

In the case of an intravenous dose of 10 mg per kg of body weight, there is a very low half-elixance of the drug. The elimination constant is 0.041 min; the apparent volume of distribution is 5.2 liters; the total clearance is 214.8 ml per minute.
The drug quickly penetrates into the organs and tissues of the human body and it is its metabolism.
The pharmacokinetics of Emoxipine may vary depending on the condition of the patient. For example, in the case of a pathological state of coronary occlusion, the rate at which the drug is excreted will be reduced, making it more bioavailable.
In the case of retrobulbar injection of Emoxipine, the active ingredients of the preparation appear almost immediately in the blood, a stably high level persists for two hours, and after 24 hours after administration, the trace from the intake is almost completely absent in the blood. A certain concentration of the drug is stored in the eye tissues.

Indications for use of Emoxipine

As eye drops, indications for use are:
    intraocular hemorrhages;
    thrombosis in the central vein of the retina of the eye and its branches;
    glaucoma;
    protection of the retina after laser coagulation and light of high intensity (in the case of solar and laser burns).
Indications for use of injections of Emoxipine:
    diabetic retinopathy;
    complicated myopathy;
    central chorioretinal dystrophy.
Also, injections of Emoxipine are used in cases of chronic and acute circulatory disorders of the brain, if these disorders are caused by hemorrhagic and ischemic disorders. If necessary, the drug can be administered as an intramuscular injection, or as an intravenous injection in ampoules.

Contraindications

The use of this drug is contraindicated during pregnancy and in case of individual hypersensitivity to one of the components.

Side effects

As side reactions, excitation can occur, which after a short time interval will be replaced by drowsiness. Possible an increase in blood pressure and the appearance of rash. Local reactions can be manifested by pain, itching, burning sensation, reddening and condensation of paraorbital tissues.

Instructions for use of Emoxipine (Method and Dosage)

Instructions for Emoxipine - eye drops

In the case of retrobulbar injection of the drug, a 1% solution in a 0.5 ml dose is administered once a day for 10-15 days. If the drug is administered subconjunctivally and parabulbarically, then from 0.2 to 0.5 ml of the drug is injected once a day for 10-30 days.
If it is necessary to protect the eye retina, the drug is administered retrobulbarno in a dosage of 0.5 ml per day and one hour before laser coagulation. The course depends on the degree of burns obtained during laser coagulation, in most cases, drops are used retrobulbno once a day for two to ten days.

Instructions for Emoxipine - Solution for Injection

In cardiology and neurology, the drug is mainly used intravenously with a dropper, at a rate of 20-40 drops per minute. The dose of the drug is 20-30 ml of a 3% solution. Droppers can be placed one to three times a day for 5-15 days. The duration of treatment directly depends on the type of the patient's illness. At the end of the droppers go to intramuscular injections of the drug: 3-5 ml of 3% solution is administered 2-3 times a day. The course of intramuscular injection is 10 to 30 days.
Emoxipine is not released in tablet form, because you can not take Emoxipine tablets, because they simply do not exist.

Overdose

In case of an overdose of the drug, the appearance or intensification of side effects may occur. When an overdose of a medicine or its analogs, blood pressure may rise, excessive excitement or drowsiness, pain in the heart area, headache, nausea, discomfort in the abdomen. Coagulation of blood may be impaired.
Treatment of an overdose of Emoxipine and analogues of Emoxipine is the abolition of the drug and the conduct of symptomatic therapy if necessary.

Interaction

In the case of using together with α-tocopherol acetate, a more active manifestation of the antioxidant properties of Emoxipine is possible. In general, taking the drug is not recommended to combine with the use of any other medicines without permission from the side of the attending physician.

Storage conditions

Keep the drug in a dark place at a temperature not exceeding 25 degrees Celsius.
Shelf life - 3 years from the date of issue.

Reviews

Emoxipine is a highly effective modern remedy. Its only drawback is a strong local irritation when used. People who have experienced serious ophthalmic diseases leave extremely positive feedback about Emoxipine, because they strictly follow the doctor's instructions and because of the seriousness of the problem they clearly understand the need for treatment. If the drug is used to treat minor ophthalmic disorders, then the testimonials about the drops will not be so positive: the fact is that not everyone is ready to accept temporary unpleasant sensations of burning after taking the drug.
Reviews of doctors about eye drops are extremely positive. The drug copes well with its task, although it causes temporary discomfort in patients.
Emoxipine injections effectively counteract the effects of strokes and heart attacks in many patients around the world. Also, taking the drug helps in a short time to reduce the various manifestations of neurological disorders. It is logical that such a positive experience of application is displayed in positive responses, both from patients and from doctors.